Programmed cell death (PCD) control in plants: New insights from the Arabidopsis thaliana deathosome

Valandro, Fernanda; Menguer, Paloma Koprovski; Cabreira-Cagliari, Caroline; Margis‐Pinheiro, Márcia; Cagliari, Alexandro

doi:10.1016/j.plantsci.2020.110603

Cited by 62 publications

(35 citation statements)

References 402 publications

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“…Inductions of morphogenetic changes are an integral part of the development of an organism. PCD is one of the major fundamental cellular processes that plays crucial role in morphogenetic changes in plant systems [13]. In plants, the occurrence of cell death during development is termed developmental PCD (dPCD).…”

Section: Central Role Of Developmental Pcd (Dpcd) In Plantmentioning

confidence: 99%

Programmed Cell Death (PCD) in Plant: Molecular Mechanism, Regulation, and Cellular Dysfunction in Response to Development and Stress

Mondal¹,

Antony²,

Roy³

et al. 2022

Regulation and Dysfunction of Apoptosis

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Programmed cell death (PCD) or apoptosis is a genetically programmed cellular process. Though in the plant, a true caspase system is lacking, still PCD can occur throughout the life cycle at any cell type, tissue, and organ part in response to a wide range of stimuli. Here we have discussed the current understanding of plant PCD in terms of different pathways, cellular dysfunction, regulation, and signaling mechanisms. Our present study discussed how and to what extent PCD is involved in pre-zygotic and post-zygotic plant life cycle and emphasized to what extent PCD modulated in response to abiotic and biotic stress. Additionally, the expression profile of different PCD-associated genes that are modulated by developmental stage, biotic-abiotic stress, cellular metabolites are also elucidated. Hence, this study will be helpful for understanding the molecular and structural instincts of PCD in different stages of plant growth and development, response to biotic/abiotic stimuli, and cellular dysfunction.

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Section: Central Role Of Developmental Pcd (Dpcd) In Plantmentioning

confidence: 99%

Programmed Cell Death (PCD) in Plant: Molecular Mechanism, Regulation, and Cellular Dysfunction in Response to Development and Stress

Mondal¹,

Antony²,

Roy³

et al. 2022

Regulation and Dysfunction of Apoptosis

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“…Many of these subcellular components, genes, and signal transduction pathways involved in PCD are functionally conserved across all domains of cellular organisms, from bacteria to fungi to plants and animals. However, there are differences in the actual mechanisms among organisms, as summarized in References [125,126].…”

Section: Programmed Cell Death and Sphingolipidsmentioning

confidence: 99%

Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls

Chen

Cheng

et al. 2020

JoF

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Sphinganine-analog mycotoxins (SAMs) including fumonisins and A. alternata f. sp. Lycopersici (AAL) toxins are a group of related mycotoxins produced by plant pathogenic fungi in the Fusarium genus and in Alternaria alternata f. sp. Lycopersici, respectively. SAMs have shown diverse cytotoxicity and phytotoxicity, causing adverse impacts on plants, animals, and humans, and are a destructive force to crop production worldwide. This review summarizes the structural diversity of SAMs and encapsulates the relationships between their structures and biological activities. The toxicity of SAMs on plants and animals is mainly attributed to their inhibitory activity against the ceramide biosynthesis enzyme, influencing the sphingolipid metabolism and causing programmed cell death. We also reviewed the detoxification methods against SAMs and how plants develop resistance to SAMs. Genetic and evolutionary analyses revealed that the FUM (fumonisins biosynthetic) gene cluster was responsible for fumonisin biosynthesis in Fusarium spp. Sequence comparisons among species within the genus Fusarium suggested that mutations and multiple horizontal gene transfers involving the FUM gene cluster were responsible for the interspecific difference in fumonisin synthesis. We finish by describing methods for monitoring and quantifying SAMs in food and agricultural products.

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“…Furthermore, although interaction of animal anti-apoptotic Bcl-2 protein with as yet to be identified plant protein might indeed decrease plant cell susceptibility to death stimuli, the lack of Bcl-2 genes in plant genomes points out that plant RCD does not rely on activity of these proteins and is thus regulated differently from the apoptotic pathway [ 36 , 37 ]. Nevertheless, original research and reviews on apoptotic hallmarks in plant cell death are still being published (for recent reviews, see [ 38 – 41 ]), propagating controversial conclusions that require careful consideration.…”

Section: Introductionmentioning

confidence: 99%

“…Since this is not a review article, we are not providing an exhausting list of relevant publications, but only representative studies illustrating controversies within the field of plant AL-PCD. More comprehensive account of previous works describing the occurrence of AL-PCD in plants can be found elsewhere [ 38 – 41 , 69 , 70 ]. HS, heat shock; PI, propidium iodide; PM, plasma membrane; TEM, transmission electron microscopy; TMRM, tetramethylrhodamine methyl ester; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling.…”

Section: Introductionmentioning

confidence: 99%

Apoptosis is not conserved in plants as revealed by critical examination of a model for plant apoptosis-like cell death

et al. 2021

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Background Animals and plants diverged over one billion years ago and evolved unique mechanisms for many cellular processes, including cell death. One of the most well-studied cell death programmes in animals, apoptosis, involves gradual cell dismantling and engulfment of cellular fragments, apoptotic bodies, through phagocytosis. However, rigid cell walls prevent plant cell fragmentation and thus apoptosis is not applicable for executing cell death in plants. Furthermore, plants are devoid of the key components of apoptotic machinery, including phagocytosis as well as caspases and Bcl-2 family proteins. Nevertheless, the concept of plant “apoptosis-like programmed cell death” (AL-PCD) is widespread. This is largely due to superficial morphological resemblances between plant cell death and apoptosis, and in particular between protoplast shrinkage in plant cells killed by various stimuli and animal cell volume decrease preceding fragmentation into apoptotic bodies. Results Here, we provide a comprehensive spatio-temporal analysis of cytological and biochemical events occurring in plant cells subjected to heat shock at 40–55 °C and 85 °C, the experimental conditions typically used to trigger AL-PCD and necrotic cell death, respectively. We show that cell death under both conditions was not accompanied by membrane blebbing or formation of apoptotic bodies, as would be expected during apoptosis. Instead, we observed instant and irreversible permeabilization of the plasma membrane and ATP depletion. These processes did not depend on mitochondrial functionality or the presence of Ca2+ and could not be prevented by an inhibitor of ferroptosis. We further reveal that the lack of protoplast shrinkage at 85 °C, the only striking morphological difference between cell deaths induced by 40–55 °C or 85 °C heat shock, is a consequence of the fixative effect of the high temperature on intracellular contents. Conclusions We conclude that heat shock-induced cell death is an energy-independent process best matching definition of necrosis. Although the initial steps of this necrotic cell death could be genetically regulated, classifying it as apoptosis or AL-PCD is a terminological misnomer. Our work supports the viewpoint that apoptosis is not conserved across animal and plant kingdoms and demonstrates the importance of focusing on plant-specific aspects of cell death pathways.

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Programmed cell death (PCD) control in plants: New insights from the Arabidopsis thaliana deathosome

Cited by 62 publications

References 402 publications

Programmed Cell Death (PCD) in Plant: Molecular Mechanism, Regulation, and Cellular Dysfunction in Response to Development and Stress

Programmed Cell Death (PCD) in Plant: Molecular Mechanism, Regulation, and Cellular Dysfunction in Response to Development and Stress

Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls

Apoptosis is not conserved in plants as revealed by critical examination of a model for plant apoptosis-like cell death

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