Programmed self-assembly of enzyme activity-inhibited nanomedicine for augmenting chemodynamic tumor nanotherapy

Abstract

The satisfactory therapeutic effect of chemodynamic therapy (CDT) dependent solely on endogenous hydrogen peroxide (H2O2) from tumor cells is difficult to achieve, which is closely attributed to the high metabolic...

Oral Metal‐Free Melanin Nanozymes for Natural and Durable Targeted Treatment of Inflammatory Bowel Disease (IBD)

“…However, metal‐based nanozymes are easily decomposed and inactivated in the gastrointestinal tract after oral administration and lose antioxidant efficacy due to the distinguishing pH value in different parts of the gastrointestinal tract. [ 32 ] Very recently, some relatively stable oral metal based nanozymes have been explored to treat IBD through complex synthesis, such as CeO 2 @MMT, [ 33 ] HfS 2 @TA, [ 34 ] etc., but the ROS scavenging ability of these metal based nanozymes is still reduced to varying degrees in the digestive tract. More importantly, IBD is a chronic disease that can persist for decades, and these metal‐based nanomedicines inevitably release metal ions to be absorbed by the body in the digestive tract, which may cause public concerns for long‐term toxicity.…”

Light-Elicited and Oxygen-Saved Iridium Nanocapsule for Oxidative Damage Intensified Oncotherapy

“…The redox imbalance of tumor cells will amplify oxidative stress [14,15]. To reduce oxidative stress damage, tumor cells have developed a variety of self-repair mechanisms [16,17]. Among them, MutT homolog1 (MTH1) in tumor cells plays a crucial role in DNA replication [18].…”

A Cu(i)-based Fenton-like agent inducing mitochondrial damage for photo-assisted enhanced chemodynamic therapy

“…via in situ Fenton or Fenton-like reactions. [8][9][10][11] Although the spontaneous response of CDT shows better ROS generation ability, however, considering the complexity and heterogeneity of the tumor microenvironment, it may restrict the occurrence of Fenton or Fenton-like reactions to some extent; thus, more attention has been devoted to introducing exogenous energy to further increase the ROS level and maximizing the therapeutic effect. [12][13][14][15] Photodynamic therapy (PDT), as another photo-induced therapy, provides a promising alternative for synergistic therapeutic treatment, which uses an external light-triggering photosensitizer (PS) to increase the content of toxic ROS (mainly including singlet oxygen, 1 O 2 ), to induce tumor cell death.…”