Programmed Switching of Single Polymer Conformation on DNA Origami

Krissanaprasit, Abhichart; Madsen, Mikael; Knudsen, Jakob S.; Gudnason, Daniel; Surareungchai, Werasak; Birkedal, Victoria; Gothelf, Kurt V.

doi:10.1021/acsnano.5b06894

Cited by 45 publications

(41 citation statements)

References 35 publications

(56 reference statements)

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“…Moreover, they can even achieve controlled conformational switching of a single polymer chain on the DNA nanotile based on toehold-mediated strand displacement (Fig. 7b) [60]. The controlled aggregation of poly(APPV-DNA) polymers in solution through varying the ionic environment and sequence-specific DNA interactions was demonstrated in their recent work [61].…”

Section: Routing Of Single Polymer Chainmentioning

confidence: 95%

DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials

Winterwerber

et al. 2020

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DNA nanotechnology, based on sequence-specific DNA recognition, could allow programmed self-assembly of sophisticated nanostructures with molecular precision. Extension of this technique to the preparation of broader types of nanomaterials would significantly improve nanofabrication technique to lower nanometer scale and even achieve single molecule operation. Using such exquisite DNA nanostructures as templates, chemical synthesis of polymer and inorganic nanomaterials could also be programmed with unprecedented accuracy and flexibility. This review summarizes recent advances in the synthesis and assembly of polymer and inorganic nanomaterials using DNA nanostructures as templates, and discusses the current challenges and future outlook of DNA templated nanotechnology.

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Section: Routing Of Single Polymer Chainmentioning

confidence: 95%

DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials

Winterwerber

et al. 2020

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“…The DNA-driven self-assembly of organic materials can be an important part in the fabrication of organic bioelectronics. [116,117] Pioneering researches have recently developed the selfassembly of multi-dimensional DNA structures with complex shapes. [32,118] The programmable assembly of brush-type DNAmodified polymers on multi-dimensional DNA origami can be used as a template via the sequence-specific recognition of DNA strands, as shown Figure 9h.…”

Section: Organic Semiconductor-dna Hybrid Assemblies For Device Applimentioning

confidence: 99%

Organic Semiconductor–DNA Hybrid Assemblies

2020

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novel optoelectronic technologies through the application of chemical and material science. [4-6] Owing to their advantages, such as facile molecular tailoring for property optimization, highly flexible adaptation, and low-cost fabrication, organic semiconductors based on polymers and small molecules containing π moieties are considered as great candidates for the essential elements of next-generation miniature consumer devices. [7-9] π-conjugated organic semiconductors have been successfully realized as a platform for various optoelectronic materials, owing to their unique light absorption, emission, and charge transfer characteristics. [10-12] Many studies have been devoted to improving the electrical and optical properties of organic semiconductors. Well-ordered assemblies based on π-conjugated polymers (CPs) and small molecules can resolve the limitations of carrier transport ability and performance stability that are common in amorphous organic materials. [13] Moreover, betterordered organic assemblies have proved to enhance optoelectronic performance owing to their high crystallinity, thereby minimizing the grain boundaries and decreasing the defect density. [14,15] There have been reviews on the assembly of organic semiconducting materials that expound on the basic principles of molecular design and selfassembly engineering, leading to the fabrication of functional nano/microstructures derived from various types of molecules. Furthermore, relevant applications on electrical, optical, and photoelectrical devices have also been demonstrated. [16-18] Notably, hybrid assembly has become an important aspect in the field of self-assembly. [19,20] Two or more types of organic semiconducting components are assembled into an ensemble through intermolecular interactions, such as van der Waals force, π-π stacking, and hydrogen bonding. [21,22] Hybrid assemblies can be classified into the following types: uniform-doped structures, [23-25] gradient-doped structures, [21] and hetero structures. [26-29] Most of these hybrid assemblies are utilized broadly as photonic elements, such as in light-emitting color barcodes, white light sources, optical wavelength converters, multiple optical channels, photoelectrical transducers, and chemical transducers. [19] Although these applications cover many aspects, only a few of them employ hybrid assemblies possessing biological functions. DNAs are generally regarded as carriers of genetic information. Nevertheless, pioneering studies, such as the study on DNA nano-architectures conducted by Seeman et al., have broadened our understanding of DNA molecules. [30,31] The outstanding Organic semiconductors are photonic and electronic materials with high luminescence, quantum efficiency, color tunability, and size-dependent optoelectronic properties. The self-assembly of organic molecules enables the establishment of a fabrication technique for organic micro-and nanoarchitectures with well-defined shapes, tunable sizes, and defect-free structures. DNAs, a class of biomacromolecules, have ...

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“…4d). Gothelf et al 79 redened DNA walking devices because they described the development of a nanomechanical device that allowed switching of the position of a single-molecule conjugated polymer (Fig. 4c).…”

Section: Other Novel Walking Devicesmentioning

confidence: 99%

“…(b) A schematic illustrating the principle of the 3D DNA nanomachine constructed by co-conjugating DNA walker and DNA track (substrate) components on a single AuNP 77. (c) An illustration of the control of the conformation of a polymer on predesigned ssDNA tracks of staple strands extending from rectangular DNA origami 79. (d) A schematic side view of a DNA origami platform with a rigid tether fixed in the center and the mechanism of cargo transport and fluorescence labeling.…”

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confidence: 99%