Objectives: Examine the long-term effects of two childhood universal prevention programs on adolescent delinquency, substance use, and antisocial behavior. Methods: The cluster randomized controlled trial involved 56 schools and 1,675 children in Zurich, Switzerland. Two evidence-based interventions, namely the social-emotional skills program PATHS and the cognitive-behavioral parenting program Triple P were implemented during the first two years of primary school, at ages 7 and 8. Outcomes were measured at ages 13 and 15 and included youth self-reports and teacher assessments. Multilevel models were used to account for the clustered nature of the interventions. Effects were estimated with inclusion of baseline covariates. Results: Across 13 outcomes related to delinquency, substance use, and antisocial behavior at ages 13 and 15, only two non-negligible effects were found. The first was a reduced prevalence of police contacts in the PATHS condition (ES =-.225). The second was a difference in competent conflict resolution skills in the combined PATHS + Triple P condition compared to the context (ES = .259), but in the unexpected direction: Participants in the combined treatment appeared to be less competent than their control group peers. All other effects were either statistically non-significant or negligible in size (i.e., ES < |.200|). Conclusions: Even 'evidence-based' interventions may have few long-term effects on delinquency, substance use, and antisocial behavior. Our findings add to the small literature on the long-term effectiveness of early universal prevention in field settings.