Progranulin as a novel biomarker in diagnosis of early-onset neonatal sepsis

Rao, Lubei; Song, Zigen; Yu, Xiaoling; Tu, Qianqian; He, Yu; Luo, Yetao; Yin, Yibing; Chen, Dapeng

doi:10.1016/j.cyto.2020.155000

Cited by 22 publications

(16 citation statements)

References 28 publications

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“…Progranulin, a 593-amino-acid autocrine growth factor that regulates the tumor necrosis factor/tumor necrosis factor receptor (TNF/TNFR) signaling system, was recently studied also in neonates and may significantly predict EOS in neonates > 34 weeks of gestation, with a cut-off value of 37.89 ng/mL, at which the sensitivity and negative predictive value was 94.34% and 91.7%, respectively. When combined with PCT, the diagnostic performance was improved to a specificity of 89.06% and positive predictive value of 81.1% [123].…”

Section: Progranulinmentioning

confidence: 98%

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

et al. 2020

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Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up to 9.8% live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages. This comprehensive review article is based on the role of biomarkers currently in use or in the research phase from a basic, translational, and clinical viewpoint that helps us to improve the quality of neonatal early-onset sepsis diagnosis and management.

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Section: Progranulinmentioning

confidence: 98%

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

et al. 2020

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“…Some novel biomarkers have been included in clinical scoring systems in combination with physical findings to improve diagnostic accuracy [ 34 ]. Whilst others have been found to be more useful in prognostication in the setting of IBI [ 35 ]. In adult populations studies have suggested combining MR-proADM with procalcitonin measurements may have high diagnostic yield and help guide prognosis in the setting of septic shock [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of mid-regional pro-Adrenomedullin as a biomarker of invasive bacterial infection in children: a systematic review

et al. 2022

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Background Invasive bacterial infections (IBI) in children present a difficult clinical challenge. They are often life-threatening, however in the early stages they can be hard to differentiate from benign viral infections. This leaves clinicians with the risk of missing a serious IBI diagnosis or inappropriately using antimicrobials in a child with a viral infection- contributing to the ongoing development of increased antimicrobial resistance. Hence, biomarkers which could aid in early detection of IBI and differentiation from viral infections are desirable. Mid-Regional pro-Adrenomedullin (MR-proADM) is a biomarker which has been associated with IBI. The aim of this systematic review was to determine its diagnostic accuracy in identifying children with IBI. Methods A strategy was devised to search online databases MEDLINE, Embase, Web of Science and Scopus for human clinical trials reporting the accuracy of MR-proADM in children. Against predesigned inclusion and exclusion criteria full texts were selected for inclusion and data extraction. True positives, false positives, true negatives and false negatives were extracted from each included study to fill 2 × 2 tables. Using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool methodological quality of each study was assessed. Results A total of 501 articles were initially identified. After the removal of duplicates and abstract screening 11 texts were fully reviewed and four texts (totaling 1404 patients) were included in the systematic analysis. Only one study was of a high quality and that study accounted for the vast majority of patients. A single study reported the diagnostic accuracy of MR-proADM for invasive bacterial infection reporting an Area under the Curve of 0.69. The paucity of available studies made meta-analysis and studies of heterogeneity impossible. Conclusion There is a paucity of research regarding the diagnostic accuracy of MR-proADM in the diagnosis of invasive bacterial infections in children. Initial results would suggest that MR-proADM testing alone is poor at identifying IBI in young children. It remains unclear if MR-proADM performs differently in older children or in children with signs and symptoms of IBI. Trial registration PROSPERO CRD42018096295.

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“…При активации эндотелиальных клеток цитокинами наблюдается быстрое повышение (в течение 1-6 ч) уровня sICAM-1 в сыворотке крови, что делает его маркером системного воспаления. В нас тоящее время существуют разногласия относительно полезности этого маркера для диагностики EOS, поскольку некоторые авторы предложили sICAM-1 в качестве ценного маркера только в первые 4 дня жизни, а другие отметили аналогичные или даже более высокие уровни у здоровых новорожденных в первые 5 дней [40,41]; 5) програнулин -аутокринный фактор роста из 593 аминокислот, который регулирует сигнальную систему TNF/TNFR, может предсказывать сепсис и СПОН у новорожденных > 34 недель беременности [42]; 6) неоптерин -биохимический маркер иммунной активности, повышение которого определяется при клеточно-опосредованном иммунном ответе; 7) резистин (FIZZ3) -белок, богатый цистеином, который играет спорную физиологическую роль в ожирении и инсулинорезистентности и повышается при системном воспалительном ответе у новорожденных, детей и взрослых, однако его диагностическую ценность еще предстоит узнать [43,44]; 8) пресепсин (ПСП) -это белок, являющийся N-концевым фрагментом рецептора макрофагов CD14 [45]. Механизм образования ПСП связан с бактериальным фагоцитозом и расщеплением CD14 лизосомальными ферментами.…”

Section: биомаркеры системного воспаленияunclassified

Multiple organ dysfunction syndrome prediction in newborn children

Golomidov¹,

Grigoryev

Мозес

et al. 2022

Innovacionnaâ medicina Kubani

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There are several directions for predicting multiple organ dysfunction syndrome (MODS), but almost all of them are poorly tested in neonatology. This review is presented to indicate the problem of the condition severity objectification of newborns and the possibility of predicting the development of MODS. Scales for assessing the severity of MODS in critically ill children have been developed and used since the end of the last century, but their validation in the newborns faces certain difficulties. Prognostic nosospecific scales: NICHD (National Institute of Child Health and Human Development) calculator, CRIB II (Clinical Risk Index for Babies), SNAPPE-II (Score for Neonatal Acute Physiology with Perinatal Extension II) are used in neonatology, however their comparison in this category of patients has not been carried out.Theoretical and practical issues of the short-term and long-term prediction of the MODS onset and its outcomes in newborns is a promising area of neonatology, since it allows a doctor to be warned about an impending catastrophe and opens a “window of opportunity” for timely correction of treatment tactics and complications prevention. Obtaining different phenotypes of critical illness and predicting their outcomes in children may have good predictive potential, but such studies have not been conducted in newborns. A promising direction in predicting MODS is the identification of biomarkers of inflammation, among which endocan, cluster of differentiation 64, cluster of differentiation molecules 11b, “pancreatic stone protein” (PSP), soluble intercellular adhesionmolecule-1 (sICAM-1), progranulin, neopterin, resistin (FIZZ3, presepsin (PSP)) carry a good potential, but their effectiveness in neonatology is still to be investigated.Thus, the prediction of MODS in children and newborns remains an unresolved problem. At the same time, several promising scientific directions are actively being developed today, which may lead to a significant breakthrough in predicting MODS in neonatology.

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Progranulin as a novel biomarker in diagnosis of early-onset neonatal sepsis

Cited by 22 publications

References 28 publications

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

Diagnostic value of mid-regional pro-Adrenomedullin as a biomarker of invasive bacterial infection in children: a systematic review

Multiple organ dysfunction syndrome prediction in newborn children

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