Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances

Huang, Guiwu; Jian, Jinlong; Liu, Chuan-Ju

doi:10.1016/j.cytogfr.2023.11.001

Cytokine & Growth Factor Reviews

2024

DOI: 10.1016/j.cytogfr.2023.11.001

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Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances

Guiwu Huang,

Jinlong Jian,

Chuan-Ju Liu

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Cited by 5 publications

(1 citation statement)

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“…The recent study revealed that intracellular PGRN has been demonstrated to modulate the process of autophagy and maintain the integrity of lysosomes in macrophages . Loss of PGRN has been reported to cause autophagic defects in macrophages, leading to lysosomal storage diseases. − Patients diagnosed with metabolic syndrome exhibit elevated levels of serum PGRN, which demonstrate a positive correlation with the presence of autophagy markers such as LC3 and Atg7 proteins . This suggests a potential association between PGRN and the autophagy activity.…”

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confidence: 99%

Progranulin Protects against Aspergillus fumigatus Keratitis by Attenuating the Inflammatory Response through Enhancing Autophagy

Qi,

Liu,

et al. 2024

ACS Infect. Dis.

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Fungal keratitis (FK) is a severe corneal condition caused by pathogenic fungi and is associated with the virulence of fungi and an excessive tissue inflammatory response. Progranulin (PGRN), functioning as a multifunctional growth factor, exerts a pivotal influence on the regulation of inflammation and autophagy. The aim of our research was to analyze the role of PGRN in Aspergillus fumigatus (A. fumigatus) keratitis. We found that PGRN expression was increased in the mouse cornea with A. fumigatus keratitis. In our experiments, corneas of mice with FK were treated with 100 ng/mL of PGRN. In vitro, RAW 264.7 cells were treated with 10 ng/mL of PGRN before A. fumigatus stimulation. The findings suggested that PGRN effectively alleviated corneal edema and decreased the expression of pro-inflammatory cytokines in mice. In stimulated RAW 264.7 cells, PGRN treatment suppressed the expression of pro-inflammatory cytokines IL-6 and TNF-α but promoted the expression of the anti-inflammatory cytokines IL-10. PGRN treatment significantly upregulated the expression of autophagy-related proteins LC3, Beclin-1, and Atg-7. 3-Methyladenine (3-MA, autophagy inhibitor) reversed the regulation of inflammatory cytokines by PGRN. In addition, our study demonstrated that PGRN also enhanced phagocytosis in RAW 264.7 cells. In summary, PGRN attenuated the inflammatory response of A. fumigatus keratitis by increasing autophagy and enhanced the phagocytic activity of RAW 264.7 cells. This showed that PGRN had a protective effect on A. fumigatus keratitis.

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confidence: 99%

Progranulin Protects against Aspergillus fumigatus Keratitis by Attenuating the Inflammatory Response through Enhancing Autophagy

Qi,

Liu,

et al. 2024

ACS Infect. Dis.

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O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation

Liang,

Chen,

Huang

et al. 2025

Biochemical and Biophysical Research Communications

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Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases

Zhou,

Hu,

et al. 2024

Bone Res

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Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significant health challenges due to their debilitating effects on the musculoskeletal system. 14-3-3 proteins, a family of conserved regulatory molecules, play a critical role in the pathology of these diseases. This review discusses the intricate structure and multifunctionality of 14-3-3 proteins, their regulation of signaling pathways, and their interactions with other proteins. We underscore the significance of 14-3-3 proteins in the regulation of osteoblasts, osteoclasts, chondrocytes, and bone remodeling, all key factors in the maintenance and dysfunction of bone and joint systems. Specific focus is directed toward elucidating the contribution of 14-3-3 proteins in the pathology of OA, RA, and bone malignancies, where dysregulated 14-3-3-mediated signaling cascades have been implicated in the disease processes. This review illuminates how the perturbation of 14-3-3 protein interactions can lead to the pathological manifestations observed in these disorders, including joint destruction and osteolytic activity. We highlight cutting-edge research that positions 14-3-3 proteins as potential biomarkers for disease progression and as innovative therapeutic targets, offering new avenues for disease intervention and management.

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Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances

Cited by 5 publications

References 162 publications

Progranulin Protects against Aspergillus fumigatus Keratitis by Attenuating the Inflammatory Response through Enhancing Autophagy

Progranulin Protects against Aspergillus fumigatus Keratitis by Attenuating the Inflammatory Response through Enhancing Autophagy

O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation

Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases

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