To improve the phase sensitivity, multi-photon subtraction schemes within the SU(1,1) interferometer are proposed. The input states are the coherent state and the vacuum state, and the detection method is homodyne detection. The effects of multi-photon subtraction on phase sensitivity, quantum Fisher information, and quantum Cramér-Rao bound are analyzed under both ideal and photon losses situations. It is shown that the internal subtraction operation can improve the phase sensitivity, which becomes better performance by increasing subtraction number. It can also efficiently improve the robustness of the SU(1,1) interferometer against internal photon losses. By comparing separatively arbitrary photon subtraction on the two-mode inside SU(1,1) interferometer, the performance differences under different conditions are analyzed, including the asymmetric properties of non-Gaussian operations on the phase precision and the quantum Fisher information. Our proposed scheme represents a valuable method for achieving quantum precision measurements.