Progress and Problems of Vaccination Against Coronavirus Infection Covid-19

Karatash, A. V.; Bilanova, L. P.; Білаш, С. М.; Проніна, Олена Миколаївна; Bilash, V. P.; Hryn, K. V.; Hryn, V. G.; Oliinichenko, Ya. O.

doi:10.29254/2077-4214-2022-3-166-50-58

VPBM

2022

DOI: 10.29254/2077-4214-2022-3-166-50-58

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Progress and Problems of Vaccination Against Coronavirus Infection Covid-19

A. V. Karatash¹,

L. P. Bilanova²,

С. М. Білаш³

et al.

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2024

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Cited by 4 publications

(2 citation statements)

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“…It is now established that infection with SARS-CoV-2 leads to acute respiratory distress syndrome, which causes severe hypoxia and pulmonary edema. This can quickly result in multiple organ failure and ultimately death [1]. Furthermore, literary sources indicate that the mortality of patients in Intensive Care Units (ICU) worldwide, is as high as 60%, despite the use of etiotropic and pathogenetic anti-inflammatory anticytokine therapy, as well as powerful anticoagulant and thrombolytic agents.…”

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confidence: 99%

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Aspects of pharmacotherapy with steroids in SARS-CoV-2 infection (literature review)

Moisieieva,

Vlasova,

Miahkokhlib

2024

ECM

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In recent years, the SARS-CoV-2 pandemic has posed a significant challenge to global public health. Furthermore, infection with SARS-CoV-2 can result in acute respiratory distress syndrome due to excessive systemic inflammation, leading to multiple organ failure and eventual death. Furthermore, the challenge of reducing excessive systemic inflammation, specifically by decreasing the production of pro-inflammatory cytokines in response to SARS-CoV-2, remains unresolved. The use of glucocorticosteroids for SARS-CoV-2 infection remains controversial. Further research is required to support the routine use of steroids in intensive care protocols for SARS-CoV-2, as the current basis is insufficient. This review provides an analysis of literary sources, guidelines, and modern international recommendations on pathogenetic therapy of SARS-CoV-2 to prevent and eliminate hyperproduction of pro-inflammatory cytokines using glucocorticosteroid agents. The aim of this work is to analyse contemporary literary sources on the clinical and pharmacological justification for the use of glucocorticosteroids in clinical practice for SARS-CoV-2 infection. The scientific literature analysis indicates that glucocorticosteroid therapy cannot be recommended for routine use in therapeutic practice for patients with SARS-CoV-2 infection. Thus, with a mild course of SARS-CoV-2 infection, when the patient does not need oxygen support, glucocorticosteroids are contraindicated. Whereas in severe course, in acute respiratory distress syndrome with severe respiratory failure, their use is absolutely necessary, and they are recommended for mandatory use. There is a need for a generalised definition of the optimal glucocorticosteroid agent, including indications, dosage, and duration of use in SARS-CoV-2 infection therapy programs. Keywords: systemic inflammatory reaction, proinflammatory cytokines, hypothalamic-pituitary-adrenal system, glucocorticosteroids.

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confidence: 99%

“…Scientific sources provide insufficient evidence for the routine use of GCs in the treatment regimens for intensive care units in the severe course of SARS-CoV-2. The advisability of using GCs remains a subject of research and debate [1][2][3].…”

mentioning

confidence: 99%

Aspects of pharmacotherapy with steroids in SARS-CoV-2 infection (literature review)

Moisieieva,

Vlasova,

Miahkokhlib

2024

ECM

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Clinical and Pharmacological Aspects of Applying Glucocorticosteroids for Sars-Covid-2 Infection: Review Article

Vakhnenko,

Moisieieva,

Vlasova

2024

Act. Probl. of the Modern Med.

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In recent years, the SARS-CoV-2 pandemic has become one of the unexpected and very serious challenges for public health around the world. Moreover, SARS-CoV-2 infection led to the development of acute respiratory distress syndrome as a result of excessive systemic inflammation, and the development of multiple organ failure, and later death. Moreover, the problem of eliminating excessive systemic inflammation, that is, reducing the production of pro-inflammatory cytokines in SARS-CoV-2, remains open. In this regard, the use of glucocorticosteroids for infection caused by SARS-CoV-2 remains quite controversial. The basis for the routine use of steroids in intensive care protocols for SARS-CoV-2 is clearly insufficient and remains the subject of further research. This review provides an analysis of literary sources, guidelines, and modern international recommendations on pathogenetic therapy of SARS-CoV-2 to prevent and eliminate hyperproduction of pro-inflammatory cytokines using glucocorticosteroid agents. The purpose of the work is to conduct an analysis of modern literary sources regarding the modern features of the clinical and pharmacological justification of the use of glucocorticosteroids in SARS-CoV-2 infection in clinical practice. The analysis of the scientific literature demonstrates that today glucocorticosteroid therapy cannot be recommended for routine use in therapeutic practice in patients with SARS-CoV-2 infection. Thus, with a mild course of SARS-CoV-2 infection, when the patient does not need oxygen support, GCS therapy is contraindicated. With a severe course of SARS-CoV-2, when the patient develops acute respiratory distress syndrome with severe respiratory failure, when there is a need for oxygen therapy, mechanical ventilation or ECMO, the use of corticosteroids is extremely necessary, and may be recommended for mandatory use. There is a pressing need for a comprehensive definition of the optimal glucocorticosteroid agent, indications, dosage, and duration of use in SARS-CoV-2 infection therapy programs. This should be done while considering biomarkers of the severity of the inflammatory process and biomarkers of the body's response to glucocorticosteroid agents.

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Strategies to Mitigate the Impact of Post-Covid-19 Syndrome on Higher Education Quality

Yarmola,

Vlasova,

Tkachenko

et al. 2024

Act. Probl. of the Modern Med.

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The SARS-CoV-2 pandemic has left a profound impact not only on the physical health of humanity but also on neurological, social, and ecological well-being. Neurological and psychological disorders resulting from the pandemic have negatively affected the quality of learning and significantly worsened learning outcomes among students in higher education institutions. The purpose of this study is to compare the prevalence and evaluate the symptoms of post-COVID syndrome, and to identify their impact on the quality of education among senior students in two higher educational institutions: Poltava State Medical University and Poltava National Pedagogical University named after V.G. Korolenko. It has been observed that damage to the nervous system and the simultaneous appearance of a combination of symptoms including headache, memory impairment, insomnia, anxiety, unmotivated weakness, and excessive fatigue are significantly high among students of both universities. The aforementioned complaints, along with the need for increased time to complete educational tasks post-illness, memory impairment, and sleep disturbances, indicate that the academic performance, psychological state, and psychosomatic background of students are at a low level. Therefore, it is essential to develop recommendations for cognitive rehabilitation tailored to this group of students, considering their significant educational workload (samples were collected from senior students). Moreover, the low and moderate physical activity levels of senior students in higher education may exacerbate symptoms of post-COVID-19 syndrome, necessitating the development of recommendations for physical rehabilitation. Students experiencing weakness, increased fatigue, reduced work capacity, sleep disturbances, and mood instability should consider reviewing the organization of the educational process, especially in distance learning conditions, and making lifestyle changes accordingly. Therefore, thoroughly elaborated healthcare recommendations and rehabilitation measures to enhance the quality of the educational process should be implemented into healthcare practice.

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Progress and Problems of Vaccination Against Coronavirus Infection Covid-19

Cited by 4 publications

References 14 publications

Aspects of pharmacotherapy with steroids in SARS-CoV-2 infection (literature review)

Aspects of pharmacotherapy with steroids in SARS-CoV-2 infection (literature review)

Clinical and Pharmacological Aspects of Applying Glucocorticosteroids for Sars-Covid-2 Infection: Review Article

Strategies to Mitigate the Impact of Post-Covid-19 Syndrome on Higher Education Quality

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