The practice of brightening and unifying skin tone dates back over many years in different communities around the world, typically by people with skin phototypes IV-VI. Even skin tone and skin homogeneity are highly desired beauty attributes, influencing consumer demand for skin radiance cosmetic products or drugs. 1 Several agents with different mechanisms of action are commonly misused, 2,3 such as topical steroids that bleach the skin and reduce its thickness, [4][5][6] and hydroquinone that reduces melanosome formation leading to melanocyte necrosis 3 and is now considered as potentially carcinogenic. 2,7 To promote inclusiveness and satisfy the consumer, the challenge remains to develop safe technologies providing perceivable benefits in skin tone evenness, while respecting the individual