Progress and prospects of magnetic iron oxide nanoparticles in biomedical applications: A review

Elahi, Narges; Rizwan, Muhammad

doi:10.1111/aor.14027

Cited by 58 publications

(32 citation statements)

References 265 publications

(508 reference statements)

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“…Fe is the fourth-most material in the earth's crust, after oxygen, silicon, and aluminum. Iron and its multiple compounds are widely applied in biomedicine [151], energy [152], and environmental remediation [153]. Aside from zero valence of Fe [154][155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170].…”

Section: Fementioning

confidence: 99%

Diverse nanomaterials synthesized by laser ablation of pure metals in liquids

Zhang

Liang

2022

Sci. China Phys. Mech. Astron.

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Diverse nanomaterials, in the forms of carbides, sulfides, oxides, metals, hydroxides, etc., have been synthesized by laser ablation in liquids (LAL) with metal targets as the dominant educts. Many advantages of LAL technique itself and its products have been revealed since 1983 when the first report about LAL was released. Different from traditional wet-chemical synthesis, one unique feature of LAL is its resultant extreme high-temperature and high-pressure local environment for the nucleation and growth of nanomaterials, despite being performed at room temperature. This extreme condition can induce the atomization and ionization of the target materials and liquid molecules to incur different chemical reactions. The laser, liquid, liquid additive, and target can significantly alter the local environment in a broad range. Thus, different phases and shapes of nanomaterials are producible even from the same target. Through directly comparing the products of LAL of 13 kinds of chosen representative metals synthesized under different conditions, this review presents and discusses current understandings, challenging issues, and perspectives related to the diversity of LAL-products, which is willing to promote a deeper investigation and discussion on a clear clarification of the chemical reactions and particle nucleation/growth processes.

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Section: Fementioning

confidence: 99%

Diverse nanomaterials synthesized by laser ablation of pure metals in liquids

Zhang

Liang

2022

Sci. China Phys. Mech. Astron.

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“…Due to their magnetic behavior, biocompatibility [68][69][70] and chemical stability, SPIONs are widely used in biomedical sciences, e.g., the management of Gramnegative bacterial infection, multimodal in vivo imaging, etc. [71][72][73][74]. However, the use of hyperthermia alone remains limited due to the potential thermal damage caused to the host tissue, as higher thermal doses are often required for the complete eradication of bacterial pathogens [75,76].…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy

et al. 2022

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A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.

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“…Furthermore, they serve as contrast agents for magnetic resonance imaging (MRI), and in stem cell therapy for monitoring, targeted delivery or triggering a desired cell differentiation. 1–5 Apart from iron oxide NPs, also non-magnetic metallic or organic NPs play a prominent role in nanoparticle-based therapies or/and as contrast agents. 6–8 In addition to the particle size and shape, the surface chemistry determines the utility of the particles, as it is responsible for the interactions with the environment.…”

Section: Introductionmentioning

confidence: 99%

“…can lead to a significant alteration in the adsorption of biomolecules and corona formation, as well as to a shift in stability, internalization, biocompatibility or biological effect of the NPs. 1 , 10–12 From this point of view, the characterization and validation of the developed particle systems should be conducted without any additional modification of the particle surface. This applies not only to the required toxicity measurements, but also to the investigation of cellular binding and uptake.…”

Section: Introductionmentioning

confidence: 99%

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

Friedrich¹,

Kappes²,

Cicha³

et al. 2022

IJN

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Label-free detection of nanoparticles is essential for a thorough evaluation of their cellular effects. In particular, nanoparticles intended for medical applications must be carefully analyzed in terms of their interactions with cells, tissues, and organs. Since the labeling causes a strong change in the physicochemical properties and thus also alters the interactions of the particles with the surrounding tissue, the use of fluorescently labeled particles is inadequate to characterize the effects of unlabeled particles. Further, labeling may affect cellular uptake and biocompatibility of nanoparticles. Thus, label-free techniques have been recently developed and implemented to ensure a reliable characterization of nanoparticles. This review provides an overview of frequently used label-free visualization techniques and highlights recent studies on the development and usage of microscopy systems based on reflectance, darkfield, differential interference contrast, optical coherence, photothermal, holographic, photoacoustic, total internal reflection, surface plasmon resonance, Rayleigh light scattering, hyperspectral and reflectance structured illumination imaging. Using these imaging modalities, there is a strong enhancement in the reliability of experiments concerning cellular uptake and biocompatibility of nanoparticles, which is crucial for preclinical evaluations and future medical applications.

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Progress and prospects of magnetic iron oxide nanoparticles in biomedical applications: A review

Cited by 58 publications

References 265 publications

Diverse nanomaterials synthesized by laser ablation of pure metals in liquids

Diverse nanomaterials synthesized by laser ablation of pure metals in liquids

Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

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