Progress and prospects: RNA-based therapies for treatment of HIV infection

Scherer, Lisa; Rossi, John J.; Weinberg, Marc S.

doi:10.1038/sj.gt.3302977

Cited by 72 publications

(52 citation statements)

References 66 publications

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“…Several molecules targeting the HIV RNA have been used to decrease HIV replication in cell culture, 12,36,37 in animal models 38 and some of them are in clinical trials for their use in gene therapy. 13,14,39 The experience with these compounds has provided several orientations and possible improvements including: (1) New compounds are always needed as leads 4 GApDh copies and normalized to a value of 100% for the hDV-Rzctl.…”

Section: Discussionmentioning

confidence: 99%

“…14,15,39,40 siRNAs have received much attention during the last years and their use against infectious agents is widely studied both in cell culture and in vivo using various methods. 41 These studies and numerous possible improvements are promising, but their use in patients will likely require their use in combination therapy to avoid viral escape.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

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In vitro and in vivo cleavage of HIV-1 RNA by new SOFA-HDV ribozymes and their potential to inhibit viral replication

Lainé¹,

Scarborough²,

Lévesque³

et al. 2011

RNA Biology

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Section: Discussionmentioning

confidence: 99%

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

In vitro and in vivo cleavage of HIV-1 RNA by new SOFA-HDV ribozymes and their potential to inhibit viral replication

Lainé¹,

Scarborough²,

Lévesque³

et al. 2011

RNA Biology

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“…Vast amount of resources are being spent by governments to develop new drugs and therapies for the treatment of infected individuals with distinct results (e.g., Scherer et al 2007). However, although several antiviral drugs have proved to successfully reduce the advance of the virus in the organism, they have also caused a series of undesired side effects.…”

mentioning

confidence: 99%

A quantitative method to establish the clinical evolution of HIV infected patients and the reproductive biology of an echinoid species from Brazil

Kellner¹

2009

An. Acad. Bras. Ciênc.

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AIDS is one of the several diseases that affect the human being. Vast amount of resources are being spent by governments to develop new drugs and therapies for the treatment of infected individuals with distinct results (e.g., Scherer et al. 2007). However, although several antiviral drugs have proved to successfully reduce the advance of the virus in the organism, they have also caused a series of undesired side effects. The most common of them are diarrhea and nausea that in several cases can severely reduce the quality of the patient's life.In order to understand the clinical evolution of HIV infected individuals, some mathematical models have been applied. In the present issue of the Anais da Academia Brasileira de Ciências (AABC), Juliana Grégio of the Instituto Tecnológico de Aeronáutica (ITA) and colleagues present a method that can be used to reduce the side effects while enhancing effectiveness of the drugs applied to HIV infected patients. The basis of this method is the optimal control theory, which is essentially a mathematical optimization method (e.g., Lewis 1986). As the authors point out, this quantitative method has been applied in a variety of fields such as economics, sociology and biology. In the present contribution, Grégio et al. (2009) discuss the problematic involving LQR (Linear Quadratic Regular) to establish the drug doses for extensive periods of treatment and advocate the use of Extended Kalman Filter for predicting the dosage of drugs in HIV infected patients in order to minimize the side effects. The authors carried out extensive simulations that have shown the possibility of decreasing drug doses and still maintaining the viral counts at a satisfactory level. As they pointed out, this quantitative method can help doctors to develop a better treatment strategy for their patients.Among the several other important papers published in the present volume of the AABC, one study provides relevant information regarding the reproduction strategy of a sea urchin (Echinoidea) from the northeastern part of Brazil. Sea urchins are important components of marine invertebrate faunas worldwide and an important food resource in some areas. Their long evolutionary history has been very useful in establishing paleoenvironments (e.g., Smith 1984) and their reproduction cycle is of great interest (e.g. Bosch et al. 1989).In some localities species of sea urchin have been regarded as responsible for the destruction of coral reefs. This impact is directly related with the amount of population present in a locality. Therefore, to evaluate the ecological interaction between rock-boring sea urchins and the reef, it is paramount to understand their life-history.

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“…Even one base pair change dramatically lowers the potency of RNAimediated inhibition. (58)This becomes important, given the high error rate of HIV-1 reverse transcriptase that leads to the emergence of RNAi escape mutants. The HIV-1 virus often becomes resistant to RNAi therapy as a result of the appearance of mutant variants.…”

Section: Targeting Hiv-1 With Rnaimentioning

confidence: 99%

Crippling of HIV at Multiple Stages with Recombinant Adeno-Associated Viral Mediated RNA Interference

Batchu¹,

Gruzdyn²,

Qazi³

et al. 2011

Recent Translational Research in HIV/AIDS

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Progress and prospects: RNA-based therapies for treatment of HIV infection

Cited by 72 publications

References 66 publications

In vitro and in vivo cleavage of HIV-1 RNA by new SOFA-HDV ribozymes and their potential to inhibit viral replication

In vitro and in vivo cleavage of HIV-1 RNA by new SOFA-HDV ribozymes and their potential to inhibit viral replication

A quantitative method to establish the clinical evolution of HIV infected patients and the reproductive biology of an echinoid species from Brazil

Crippling of HIV at Multiple Stages with Recombinant Adeno-Associated Viral Mediated RNA Interference

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