Progress in and promise of bacterial quorum sensing research

Whiteley, Marvin; Diggle, Stephen P.; Greenberg, E. Peter

doi:10.1038/nature24624

Cited by 967 publications

(747 citation statements)

References 111 publications

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“…Consequently, and for historical reasons, such (pheromonal) behaviour has become known, in prokaryote biology, as 'quorum sensing' (see e.g. [167][168][169]). It provides another general example of secretory processes involving small molecules that have selective advantage for the host, and has applications in biotechnology [170,171].…”

Section: Why Would Microbes Excrete Expensively Produced Biochemicals?mentioning

confidence: 99%

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Control of metabolite efflux in microbial cell factories: current advances and future prospects

Kell¹

2018

Preprint

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The yield and ease of purification of biotechnological products are typically greatly enhanced if they can be secreted into the external medium. Although not universally appreciated, however, small molecule biotechnological products do not ‘float across’ the phospholipid bilayer portion of biological membranes, and thus they need transporters to assist their passage into the extramembrane and extracellular spaces. Some of these transporters may be reversible, equilibrative transporters that might more normally be used for uptake, while others may have an efflux directionality imposed on them via suitable energy coupling mechanisms. Despite the energetic costs of small molecule synthesis, natural evolution does in fact provide a number of mechanisms by which the secretion of such products can actually enhance fitness. Where available these provide useful starting points, and assaying for such activities is crucial. In particular, in a systems biology approach, we first need to identify such/suitable activities before we can seek to increase them. They may then be improved through promoter engineering, via manipulation of control elements, or by directed evolution of the transporter proteins themselves. Modern methods of synthetic biology provide enormous opportunities for all kinds of efflux transporter engineering; they are just beginning to be realised.

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Section: Why Would Microbes Excrete Expensively Produced Biochemicals?mentioning

confidence: 99%

“…While microbes even of the same genotype are purposely highly heterogeneous physiologically [311,312], even in the same media, the biotechnologist might wish to turn on and off pathways in 'all' cells at once; 'quorum sensing' methods are one means to seek to do this [169,313].…”

Section: Control Factor Expression Engineeringmentioning

confidence: 99%

Control of metabolite efflux in microbial cell factories: current advances and future prospects

Kell¹

2018

Preprint

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“…This gives beneficial cooperation with each other, behavior as a powerful multicellular community, and performance of tasks, which would be impossible for single cells [1]. Sophisticated QS networks exist in both Gram-negative and Gram-positive bacteria, and they communicate via many different circuits and various signal molecules.…”

Section: Qs Signaling Network In P Aeruginosamentioning

confidence: 99%

“…This form of bacterial intercellular signaling coordinates gene regulation and controls numerous cooperative behaviors, including biofilm formation, virulence traits, metabolic demands, and host-microbe interactions [1]. Multicellular eukaryotic organisms have coexisted with bacteria for approximately 2 billion years under evolutionary pressure and both represent remarkable examples of adaptive evolution.…”

Section: Introductionmentioning

confidence: 99%

Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of <b><i>Pseudomonas aeruginosa</i></b> Infections

Turkina

Vikström

2018

J Innate Immun

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Cell-to-cell signaling via small molecules is an essential process to coordinate behavior in single species within a community, and also across kingdoms. In this review, we discuss the quorum sensing (QS) systems used by the opportunistic pathogen Pseudomonas aeruginosa to sense bacterial population density and fitness, and regulate virulence, biofilm development, metabolite acquisition, and mammalian host defense. We also focus on the role of N-acylhomoserine lactone-dependent QS signaling in the modulation of innate immune responses connected together via calcium signaling, homeostasis, mitochondrial and cytoskeletal dynamics, and governing transcriptional and proteomic responses of host cells. A future perspective emphasizes the need for multidisciplinary efforts to bring current knowledge of QS into a more detailed understanding of the communication between bacteria and host, as well as into strategies to prevent and treat P. aeruginosa infections and reduce the rate of antibiotic resistance.

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“…Therefore, multiplayer games are not just theoretically interesting [62], but have clear biological [13] as well as social interpretations. From multiple bacteria interacting together as in microbiomes [95], in quorum sensing [93] or during biofilm formation [22] to social dilemmas such as the classic tragedy of the commons [40], evolutionary games can be interpreted across scales of organization. For an extensive account for the applications of multiplayer games in biology we refer to Broom [10].…”

Section: Introductionmentioning

confidence: 99%

Disentangling eco-evolutionary effects on trait fixation

Czuppon

Gokhale

2018

Preprint

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In population genetics, fixation of traits in a demographically changing population under frequencyindependent selection has been extensively analyzed. In evolutionary game theory, models of fixation have typically focused on fixed population sizes and frequency-dependent selection. However, combining ecological fluctuations with frequency-dependent interactions such as Lotka-Volterra dynamics and thus the analysis of eco-evolutionary fixation has received comparatively little attention. Here, we consider a two-type stochastic competitive Lotka-Volterra model with higher order interactions. The emerging individual based model allows for stochastic fluctuations not just in the frequencies of the two types but the total population size as well. Assuming weak selective di↵erences between the traits we approximate the fixation probability for di↵ering competition coe cients. We find that it resembles qualitatively the corresponding evolutionary deterministic dynamics within a population of fixed size. Furthermore, we analyze and partially disentangle the selection e↵ects into their ecological and evolutionary components. Concretely, we show that the evolutionary selection intensity has a larger e↵ect on the predictive power of our approximation than the ecological selection. However, the fixed points themselves are also a↵ected by the selection intensity which implies that a clean separation of the ecological and evolutionary impacts on the evolutionary outcome of the model is not possible. The entanglement of eco-evolutionary processes in a co-evolutionary system is thus a reality which needs to be considered when determining the fixation properties in populations of fluctuating size.

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Progress in and promise of bacterial quorum sensing research

Cited by 967 publications

References 111 publications

Control of metabolite efflux in microbial cell factories: current advances and future prospects

Control of metabolite efflux in microbial cell factories: current advances and future prospects

Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of <b><i>Pseudomonas aeruginosa</i></b> Infections

Disentangling eco-evolutionary effects on trait fixation

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