Progress in Cleveland Clinic–Nimbus Total Artificial Heart Development

Harasaki, Hiroaki; Fukamachi, Kiyotaka; Massiello, Alex; Chen, Jifeng; Himley, Stephen; Fukumura, Fumio; Muramoto, Kazuhiro; Niu, Satoshi; Wika, K.; Davies, Charles R.; McCarthy, Patrick M.; Kiraly, R; Thomas, D.; Rintoul, Thomas C.; Carriker, J.; Maher, Timothy R.; Butler, Kenneth C.

doi:10.1097/00002480-199407000-00049

Cited by 18 publications

(5 citation statements)

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“…They report a maximum pump output of 7.5 L/min with an electrical‐to‐hydraulic efficiency of approximately 19%. The overall efficiency of the CCF‐Nimbus TAH ranged from 10.5 to 20.4% ( 7), and Masuzawa reported that the maximum work efficiency of his electrohydraulic TAH was 8% ( 8). The total efficiency of our system is low compared with other systems.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of an Implantable Motor‐Driven Left Ventricular Assist Device

et al. 1999

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A console based implantable motor-driven left ventricular assist device (LVAD) was developed and tested. Ten sheep weighing 42-73 kg (mean, 54.4 kg) were used as the experimental animals. Four animals survived 5-12 h (mean, 9.5 h). The mean pump flow was 1.63 L/min, ranging from 0.8 to 2.5 L/min. The cause of termination was respiratory failure in 3 animals, bleeding in 2, ventricular fibrillation in 2, vent tube obstruction in 1, thrombus formation in 1, and mechanical failure of the driving console in 1. Following the in vivo studies, the computer regulated controller was tested in a mock circulatory system. The LVAD provided 5.34 L/min of maximum output against a mean afterload of 80 mm Hg with a filling pressure of 15 mm Hg when the pump rate was 80 bpm in the fixed rate mode. With an increase in the pump afterload from 80 to 140 mm Hg, the total system efficiency varied from 7.81 to 8.34% when the pump preload was 15 mm Hg. An ultracompact, completely implantable electromechanical VAD has been under development. This device should fit in a 60 kg adult. As the next step, we are preparing to implant this ultracompact implantable VAD with an electronic controller in an animal model with better results being expected.

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Section: Discussionmentioning

confidence: 99%

Evaluation of an Implantable Motor‐Driven Left Ventricular Assist Device

et al. 1999

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“…The EH-TAH, Nimbus TAH, and the Penn State TAH have not been implanted in patients, but reported long follow-up durations in animals >90 days, suggesting successful ventricular balancing mechanisms. 35,43,44 The other TAHs (ReinHeart, Softheart, Baylor TAH, Vienna, BRNO, and Mushroom TAH) did not report on long-term support during (pre)clinical studies.…”

Section: In Vivo Performancesmentioning

confidence: 99%

“…The AbioCor TAH (no longer in development) has been implanted in 14 patients, with a maximum survival of 512 days, 42 indicating that the cardiac outputs remained balanced. The EH‐TAH, Nimbus TAH, and the Penn State TAH have not been implanted in patients, but reported long follow‐up durations in animals >90 days, suggesting successful ventricular balancing mechanisms 35,43,44 . The other TAHs (ReinHeart, Softheart, Baylor TAH, Vienna, BRNO, and Mushroom TAH) did not report on long‐term support during (pre)clinical studies.…”

Section: In Vivo Performancesmentioning

confidence: 99%

Balancing the ventricular outputs of pulsatile total artificial hearts

Gülcher,

Vis,

Peirlinck

et al. 2023

Artificial Organs

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BackgroundMaintaining balanced left and right cardiac outputs in a total artificial heart (TAH) is challenging due to the need for continuous adaptation to changing hemodynamic conditions. Proper balance in ventricular outputs of the left and right ventricles requires a preload‐sensitive response and mechanisms to address the higher volumetric efficiency of the right ventricle.MethodsThis review provides a comprehensive overview of various methods used to balance left and right ventricular outputs in pulsatile total artificial hearts, categorized based on their actuation mechanism.ResultsReported strategies include incorporating compliant materials and/or air cushions inside the ventricles, employing active control mechanisms to regulate ventricular filling state, and utilizing various shunts (such as hydraulic or intra‐atrial shunts). Furthermore, reducing right ventricular stroke volume compared to the left often serves to balance the ventricular outputs. Individually controlled actuation of both ventricles in a pulsatile TAH seems to be the simplest and most effective way to achieve proper preload sensitivity and left–right output balance. Pneumatically actuated TAHs have the advantage to respond passively to preload changes.ConclusionTherefore, a pneumatic TAH that comprises two individually actuated ventricles appears to be a more desirable option—both in terms of simplicity and efficacy—to respond to changing hemodynamic conditions.

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“…Plusieurs groupes l'ont adopté [39][40][41]. Deux chambres distinctes en polyuréthane reproduisent les ventricules droit et gauche du coeur et sont insérées dans un boîtier métallique.…”

Section: Le Coeur Artificiel Total Implantable (Cati) : Du Concept Peunclassified

Sélection des matériaux pour la conception et le développement du boîtier d'un cœur artificiel total implantable : supériorité du titane et de ses alliages

Guidoin

2004

ITBM-RBM

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Progress in Cleveland Clinic–Nimbus Total Artificial Heart Development

Cited by 18 publications

References 0 publications

Evaluation of an Implantable Motor‐Driven Left Ventricular Assist Device

Evaluation of an Implantable Motor‐Driven Left Ventricular Assist Device

Balancing the ventricular outputs of pulsatile total artificial hearts

Sélection des matériaux pour la conception et le développement du boîtier d'un cœur artificiel total implantable : supériorité du titane et de ses alliages

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