Accidental transients in fusion reactors, such as the in-vessel Loss-of-Coolant Accident (LOCA) considered here, are generally analyzed using system-level codes. However, because of their lumped nature, such tools cannot predict local pressure and temperature values, which are instead of interest to assess the integrity of the Vacuum Vessel (VV) structures. It is then fundamental to prove that the system-level tools' predictions are at least conservative. In this work, we analyze the helium flow inside the VV following a LOCA in the helium-cooled blanket of the EU DEMO, using a 3D transient CFD model implemented in the commercial STAR-CCM+ code. In view of the large pressure ratio, a hypersonic flow regime (Ma > 5) develops, with the formation of shock fronts requiring a high time and space resolution. The model is applied to compute the evolution of the pressure distribution inside the VV and then to compare it with the information provided by the system-level GETTHEM model. The predictions by the two models of the intervention time of the VV pressure suppression system are compared, showing that the 0D model is conservative.