Progress in functionalization of magnetic nanoparticles for applications in biomedicine

Abstract

Magnetic nanoparticles (mNPs) ranging from the nanometre and micrometre scale have been widely applied in recent years in the area of biomedicine. They contain unique magnetic properties and due to their size can function at a cellular level, making them attractive candidates for cell labelling, imaging, tracking and as carriers. A recent surge of interest in nanotechnology has boosted the breadth and depth of the nanoparticle research field. This review aims to supplement a previously published review in 2003 and address more recent advances in the uses and bioapplications of mNPs and future interesting perspectives.

Preparation of silica coated cobalt ferrite magnetic nanoparticles for the purification of histidine-tagged proteins

“…Depending on type of applications, magnetic nanoparticles are used in varieties of forms such as surface functionalized particles in biomedical applications, particles arrays in magnetic storage media, compacted powders in permanent magnets, and ferrofluids ( Figure 18) (Berry & Curtis, 2003) , (Chinnasamy, Senoue, Jeyadevan, Perales-Perez, Shinoda, & Tohji, 2003). …”

Differences in Magnetic Particle Uptake by CNS Neuroglial Subclasses: Implications for Neural Tissue Engineering

“…These advanced materials are used in key applications such as drug/gene delivery, magnetic drug targeting, thermotherapies, stem cell targeting, and in diagnostic imaging (as contrast agents) [2][3][4][5][6]. The size and surface chemistry of MPs can be tailored for molecules with which they are 'functionalized', enabling the construction of multimodal particles that can mediate combinations of cellular applications, whilst retaining nanoscale dimensions [7]. The unique versatility achievable with their structural design therefore confers on MPs the ability to serve as a 'theragnostic platform' to integrate therapeutic strategies with diagnostic methods such as MRI [8].…”

The influence of particle size and static magnetic fields on the uptake of magnetic nanoparticles into three dimensional cell‐seeded collagen gel cultures

“…5 Magnetic nanoparticles are composed of a metal core with a biocompatible surface coating. 6 Iron oxide is the most commonly used nanoparticle core metal because it possesses superparamagnetic properties, thus allowing the possibility of remotely controlling the NP location. 7 A further benefit of iron oxide core nanoparticles has been in the treatment of cancer patients.…”