Progress in Functionalized Biodegradable Polyesters

Potentially biocompatible polyacrylamides derived by the Ugi four-component reaction

“…For example, polycaprolactone, often used in tissue engineering, is known for its excellent biocompatibility, but also for its poor thermal and mechanical properties [9]. Polymers, such as polyamides, overcome these drawbacks through blending or incorporation into copolymers, or by modification of their side-chains to introduce the desired physical properties [10][11][12][13]. Polyethylene glycol (PEG) has also proven to be a synthetic polymer with excellent biocompatibility for use in many biomedical applications [14,15].…”

Composite tendon implant based on nanofibrillar polyhydroxybutyrate and polyamide filaments

“…Among the biodegradable, biocompatible, and thrombus‐resistant polymers, of special note are the polyhydroxyalkanoates (PHA), of which poly‐3‐hydroxybutyrate (PHB) is the most widely studied polymer . PHB is currently used to develop a range of medical products for dentistry, cardio surgery, orthopedics, and other areas …”

“…2 Among the biodegradable, biocompatible, and thrombusresistant polymers, of special note are the polyhydroxyalk-Correspondence to: V. Sevastianov; e-mail: viksev@yandex.ru Contract grant sponsor: Russian Foundation for Basic Research; contract grant number: 13-02-12407 OFI_m2 and 15-59-32401 RT-omi anoates (PHA), of which poly-3-hydroxybutyrate (PHB) is the most widely studied polymer. 3 PHB is currently used to develop a range of medical products for dentistry, cardio surgery, orthopedics, and other areas. [4][5][6] It is well known that implants can promote restoration of damaged connective tissue and ensure the performance of its function.…”

Cyclic Comonomers for the Synthesis of Carboxylic Acid and Amine Functionalized Poly(l-Lactic Acid)

“…They suffer from the absence of any functional moieties along the polyester backbone that are amenable for a functionalization of the materials in order to exploit a wider array of applications depending on those kinds of interactions between the materials and biological systems. Thus the functionalization of PLA is an active area of research and numerous routes have been developed to achieve this goal [17]. Among those are the usage of functional initiators, resulting in chain-end functionalized polymers [18], and post-polymerization procedures such as hydrolysis and aminolysis reactions [19,20].…”