Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis

Peng, Yi; Deng, Xiang; Yang, Shanshan; Nie, Wei; Tang, Yan-Dan

doi:10.1007/s11655-022-3535-6

Cited by 11 publications

(8 citation statements)

References 28 publications

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Section: Discussionmentioning

confidence: 99%

“…Various isoflavones have been found in AM( Peng et al, 2022 ). Here, eight active isoflavones were identified as rutin, calycosin-7-O-β-D-glucoside, ononin, daidzein, calycosin, kaempferol, isorhamnetin and formononetin in AME using LC-MS techniques, which is consistent with previous reports ( Shan et al, 2019 ; Peng et al, 2022 ). According to the active components of AM for treating IBD chose by using network pharmacology analysis ( Supplementary Table S1 ), 24 components were used to detect the anti-inflammatory effect in adult flies.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila

Li²,

Yang³

et al. 2022

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation, which currently lacks safe and effective medicines. Astragalus membranaceus (AM), also named Huangqi, is one of the most commonly used fundamental herbs in China. Here, we aimed to investigate mechanism and bioactive compounds of AM on treating sodium dodecyl sulfate (SDS)- induced colitis in Drosophila flies. Our data showed that AM extract (AME) supplementation had no toxic effect in flies, and protected flies against SDS-induced lifespan shortening, intestinal morphological damage, and colon length shortening. Moreover, AME supplementation remarkably rescued SDS-induced intestinal stem cell (ISC) overproliferation and increased reactive oxygen species (ROS) level in the intestine. Mechanistically, AME remarkably rescued the altered expression levels of genes and proteins in c-Jun N-terminal kinase (JNK) and JAK-STAT signaling pathways induced by SDS in gut. Additionally, formononetin, isoliquiritigenin, isorhamnetin, astragaloside I, astragaloside III, vanillic acid, and caffeic acid in AM had protection against SDS-induced inflammatory damage in flies. Taken together, AME could ameliorate the intestinal inflammation partially by suppressing oxidative stress-associated JNK signaling and JAK-STAT signaling pathways. AME may provide a theoretical basis for natural medicine toward treating intestinal inflammatory disease in human.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila

Li²,

Yang³

et al. 2022

Front. Pharmacol.

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“…Astragalus membranaceus (Huang Qi, polysaccharides, flavonoids, and saponins): This herb helps boost the immune system and may alleviate MS symptoms by influencing the gut microbiota composition (Peng et al 2023 ).…”

Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

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The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general health as it contributes to multiple aspects of host physiology. Recent research has revealed a dynamic connection between the gut microbiota and the central nervous system, that can influence neurodegenerative diseases (NDs). Indeed, imbalances in the gut microbiota, or dysbiosis, play a vital role in the pathogenesis and progression of human diseases, particularly NDs. Herbal medicine has been used for centuries to treat human diseases, including NDs. These compounds help to relieve symptoms and delay the progression of NDs by improving intestinal barrier function, reducing neuroinflammation, and modulating neurotransmitter production. Notably, herbal medicine can mitigate the progression of NDs by regulating the gut microbiota. Therefore, an in-depth understanding of the potential mechanisms by which herbal medicine regulates the gut microbiota in the treatment of NDs can help explain the pathogenesis of NDs from a novel perspective and propose novel therapeutic strategies for NDs. In this review, we investigate the potential neuroprotective effects of herbal medicine, focusing on its ability to regulate the gut microbiota and restore homeostasis. We also highlight the challenges and future research priorities of the integration of herbal medicine and modern medicine. As the global population ages, access to this information is becoming increasingly important for developing effective treatments for these diseases.

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“…9 At present, studies have also verified that Huangqi (Radix Astragali) has the effects of antioxidant, anti-inflammatory, analgesic, anticancer, thrombosis preventing, hypoglycemic, lipid regulating, immune regulating, and antiaging. [10][11][12] Guizhi (Ramulus Cinnamomi) Guizhi (Ramulus Cinnamomi) is the dry twigs of the Lauraceae plant cinnamon, mainly growing in the Guangdong, Guangxi and Yunnan provinces. Its medicinal use was first recorded in Shennong's Classic of Materia Medica (Shen Nong Ben Cao Jing), followed by the books on herbal medicines of all dynasties.…”

Section: Huangqi (Radix Astragali)mentioning

confidence: 99%

Application of Huangqi Guizhi Wuwu Decoction in Orthopaedics and Traumatology

Tan

Wang

et al. 2022

Chinese medicine and natural products

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The Huangqi Guizhi Wuwu Decoction(HQGZWWT) is composed of Huangqi (Astragali Radix), Shaoyao (Paeoniae Radix Alba), Guizhi (Cinnamomi Ramulus), Shengjiang (Zingiberis Rhizoma Recens), and Dazao (Jujubae Fructus) which has various pharmacological anti-inflammatory, analgesic, antioxidant, antitumor, lipid-lowering, and immunity-regulating activities. It has certain advantages in the treatment of orthopaedic diseases, such as cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, knee osteoarthritis, rheumatoid arthritis, myofascial pain syndrome, etc., with outstanding clinical efficacy, few adverse reactions, and high patient compliance. However, modern pharmacological researches on the whole prescription of HQGZWWT are insufficient and the therapeutic targets are not clear which needs further exploration. Besides, this prescription cannot treat all orthopaedic diseases, so we should adhere to the thinking of four diagnostics in traditional Chinese medicine (TCM), select prescriptions based on syndrome differentiation, closely follow the pathogenesis, innovate and expand its scope of application, reflect the application advantages of this prescription in orthopaedics and traumatology and improve the total clinical efficiency.

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Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis

Cited by 11 publications

References 28 publications

Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila

Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Application of Huangqi Guizhi Wuwu Decoction in Orthopaedics and Traumatology

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