Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy

Yang, Yuling; Lin, Ke; Yang, Li

doi:10.3390/pharmaceutics13111951

Cited by 19 publications

(14 citation statements)

References 230 publications

(205 reference statements)

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“…Polyvinylpyrrolidone (PVP) enabled the Ce6 loading efficiency of MIP NPs to be as high as 76.07 ± 0.52%, and could shed PVP from the surface of MIP NPs in an acidic microenvironment, realizing the local enrichment of MIP NPs at tumor. Besides MnO 2 , CeO 2 also has similar functions to catalase (CAT) and superoxide dismutase ( Yang Y.-L. et al, 2021 ). Zeng et al prepared a dual-targeted tumor drug delivery system (ICG@PEI−PBA−HA/CeO 2 ) by using ICG, inorganic nanozyme (HA/CeO 2 ) and pH-sensitive cationic polymer carrier phenylboronic acid-modified polyethyleneimine-4-carboxyphenylboronate (PEI-PBA) Zeng et al (2021) .…”

Section: Strategies For Nanoparticle-based Photocontrolled Deliverymentioning

confidence: 99%

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Chen

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.

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Section: Strategies For Nanoparticle-based Photocontrolled Deliverymentioning

confidence: 99%

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Chen

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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“… 9 Based on the photosensitizer and its localization, the acute vascular response can be useful in predicting the overall response to PDT. These approaches are particularly important for predominantly vascular-based photosensitizers such as dextran-benzoporphyrin derivative (BPD) 28 and TOOKAD. Thus, it is important to consider blood flow in tissue undergoing PDT, such as laser speckle imaging.…”

Section: Photoimmunoconjugatementioning

confidence: 99%

“…The anti-tissue factor (TF) antibody 1849-ICG can specifically bind to TF highly expressed BXPC-3 cells, induce rapid death of tumor cells and significantly inhibit tumor growth in vivo after NIR illumination. 28 The development of new targets and strategies has led to improved effects of photoimmunotherapy. In addition to targeting antigens on the surface of tumor cells, PIT can also act on other targets to achieve the purpose of tumor therapy.…”

Section: Opportunities and Prospectsmentioning

confidence: 99%

Photoimmunotherapy: A New Paradigm in Solid Tumor Immunotherapy

Peng

Huang

2022

Cancer Control

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In recent years, the incidence of cancer has been increasing worldwide. Conventional cancer treatments include surgery, chemotherapy, and radiation, which mostly kill tumor cells at the expense of normal and immune cells. Although immunotherapy is an accurate, rapid, efficient tumor immune treatment, it causes serious adverse reactions, such as cytokine release syndrome (CRS) and neurotoxicity. Therefore, there is an urgent need to develop an effective and nontoxic procedure for immunotherapy. The clinical combination of phototherapy and immunoadjuvant therapy can induce immunogenic cell death and enhance antigen presentation synergy. It also causes a systemic antitumor immune response to manage residual tumors and distant metastases. Photoimmunotherapy (PIT) is a tumor treatment combining phototherapy with immunotherapy based on injecting a conjugate photosensitizer (IR700) and a monoclonal antibody (mAb) to target an expressed antigen on the tumor surface. This combination can enhance the immune response ability, thus having a good effect on the treatment of residual tumor and metastatic cancer. In this review, we summarize the recent progress in photoimmunotherapy, including photoimmunoconjugate (PIC), the activation mechanism of immunogenic cell death (ICD), the combination therapy model, opportunities and prospects. Specifically, we aim to provide a promising clinical therapy for solid tumor clinical transformation.

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“…armaceutics 2022, 14, 1375 2 of 16 subcellular structures, such as cell membrane and organelle membrane, by the rapid oxidation of biomolecules, in a localized manner [5][6][7], as ROS are extremely active with a short diffusion radio. More importantly, cancer phototherapy showed a synergistic effect with other cancer therapies by promoting a cargo release upon laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Nanoplatforms for Tumor Phototherapy: An Update

Chen

Guo

et al. 2022

Pharmaceutics

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Tumor phototherapies are light-mediated tumor treatment modalities, which usually refer to tumor photothermal therapy (PTT) and photodynamic therapy (PDT). Due to the outstanding spatial-temporal control over treatment through light irradiation, tumor phototherapies display extremely low side effects during treatment and are believed to be a tumor treatment method with a clinical translation potential. However, current tumor phototherapy nanoplatforms face obstacles, including light irradiation-induced skin burning, tumor hypoxia microenvironments, limited light penetration depth, et al. Therefore, one important research direction is developing a tumor phototherapy nanoplatform with multifunctionality and enhanced pharmacological effects to overcome the complexity of tumor treatment. On the other hand, cyclodextrins (CDs) are starch-originated circular oligosaccharides with negligible toxicity and have been used to form supermolecular nanostructures through a host–guest interaction between the inner cavity of CDs and functional biomolecules. In the past few years, numerous studies have focused on CD-based multifunctional tumor phototherapy nanoplatforms with an enhanced photoeffect, responsive morphological transformation, and elevated drug bioavailability. This review focuses on the preparation methods of CD-based tumor phototherapy nanoplatforms and their unique physiochemical properties for improving anti-tumor pharmacological efficacy.

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Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy

Cited by 19 publications

References 230 publications

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Photoimmunotherapy: A New Paradigm in Solid Tumor Immunotherapy

Cyclodextrin-Based Nanoplatforms for Tumor Phototherapy: An Update

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