Progress in Parkinson's disease animal models of genetic defects: Characteristics and application

Zhang, Chutian; Chen, Shiya; Li, Xiyu; Xu, Qian; Ye, Lin; Liu, Fan; Yuan, Man; Zi, Yong; Cai, Jun

doi:10.1016/j.biopha.2022.113768

Cited by 6 publications

(4 citation statements)

References 204 publications

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“…Similarly, other studies showed that models of genetic defects, such as abnormal α-syn encoding, defects in the autophagy-lysosome system, ubiquitin protease system defects and mitochondria-related dysfunction, can lead to a similar pathogenesis to PD, which is of great relevance in the search for possible primary treatments to combat symptomatology due to genetic defects [ 103 , 104 , 105 ].…”

Section: Discussionmentioning

confidence: 96%

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Rangel

Marín-Márquez

Hernández-Contreras

et al. 2023

IJMS

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Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD.

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Section: Discussionmentioning

confidence: 96%

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Rangel

Marín-Márquez

Hernández-Contreras

et al. 2023

IJMS

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“…Indeed, more than five thousand manuscripts dealing with the association between Parkinson’s disease and mitochondrial alteration can be found on PubMed ( Figure 2 ). In addition, due to studies on PD, particularly genetic Parkinsonism, all mitochondrial dysfunctions leading to cell death have been well defined [ 75 ]. The PINK1 gene mutation, responsible for an early onset of Parkinsonism, serves as a good example [ 76 ].…”

Section: Role Of Mitochondria In Neurodegenerative Diseasementioning

confidence: 99%

Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson

Tassone

Meringolo

Ponterio

et al. 2023

IJMS

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Strong evidence suggests a correlation between degeneration and mitochondrial deficiency. Typical cases of degeneration can be observed in physiological phenomena (i.e., ageing) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have the dyshomeostasis of mitochondrial bioenergy as a common denominator. Neurodegenerative diseases show bioenergetic imbalances in their pathogenesis or progression. Huntington’s chorea and Parkinson’s disease are both neurodegenerative diseases, but while Huntington’s disease is genetic and progressive with early manifestation and severe penetrance, Parkinson’s disease is a pathology with multifactorial aspects. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early-onset diseases linked to gene mutations, while others could be idiopathic, appear in young adults, or be post-injury senescence conditions. Although Huntington’s is defined as a hyperkinetic disorder, Parkinson’s is a hypokinetic disorder. However, they both share a lot of similarities, such as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc. In this review, we will describe the start and development of both diseases in relation to mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.

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“…Indeed, more than five thousand manuscripts dealing with the association between Parkinson's disease and mitochondrial alteration can be found on Pubmed. In addition, due to studies on PD, particularly genetic Parkinsonism, all mitochondrial dysfunction leading to cell death has been well defined [76]. PINK1 gene mutation, responsible for an early onset Parkinsonism, is an example [77].…”

Section: Role Of Mitochondria In Degenerative Diseasementioning

confidence: 99%

Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson

Tassone¹,

Meringolo²,

Bonsi³

et al. 2023

Preprint

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Much evidence suggests a correlation between degeneration and mitochondrial impairment. Typical cases of degeneration can also be observed in physiological phenomena (aging) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have as a common denominator the dyshomeostasis of mitochondrial bioenergy. Even neurodegenerative diseases show a bioenergetics imbalance in their pathogenesis or progression. Huntington's chorea and Parkinson's disease are both neurodegenerative diseases, but while Huntington's disease is a genetic, and progressive disease with early manifestation and severe penetrance, Parkinson's disease is a pathology with a multifactorial aspect. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early onset diseases linked to gene mutation, others can appear in young adults and senescent only post-injury, and a final group is idiopathic. Huntington's was defined as a hyperkinetic disorder, while Parkinson's is a hypokinetic disorder; but in the middle, there are a lot of similarities as well as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc. In the review, we would embrace the theories that both diseases start and develop in light of mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.

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Progress in Parkinson's disease animal models of genetic defects: Characteristics and application

Cited by 6 publications

References 204 publications

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson

Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson

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