Progress in Personalized Psychiatric Therapy with the Example of Using Intranasal Oxytocin in PTSD Treatment

Abstract

Post-traumatic stress disorder (PTSD) is a severe mental disorder that results in the frequent coexistence of other diseases, lowers patients’ quality of life, and has a high annual cost of treatment. However, despite the variety of therapeutic approaches that exist, some patients still do not achieve the desired results. In addition, we may soon face an increase in the number of new PTSD cases because of the current global situation—both the COVID-19 pandemic and the ongoing armed conflicts. Hence, in recent years, many publications have sought a new, more personalized treatment approach. One such approach is the administration of intranasal oxytocin (INOXT), which, due to its pleiotropic effects, seems to be a promising therapeutic option. However, the current findings suggest that it might only be helpful for a limited, strictly selected group of patients.

Baculovirus Display of Peptides and Proteins for Medical Applications

“…Another candidate is the nonapeptide oxytocin, a hormone with multiple functions including social bonding, reproduction, and childbirth [ 108 ]. Recent studies have shown that oxytocin treatment may play a role in improving autism [ 109 ] and other mental disorders such as post-traumatic stress disorder (PTSD) [ 110 ]. Relatively larger peptides such as leptin may be also relevant targets of baculovirus display.…”

Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder

“…Rapid anxiolytic effects of intranasal oxytocin have been observed in non-clinical human participants, albeit in a manner dependent upon the chronicity of administration and inter-individual variables including age, gender and psychosocial functioning ( Naja and Aoun, 2017 ; Neumann and Slattery, 2016 ). Variability in response magnitude across individuals has also characterized the behavioral and neural (e.g., amygdala and PFC activity) effects of intranasal oxytocin in small-scale PTSD studies to-date (reviewed in ( Peled-Avron et al, 2020 ; Sandra Szafoni, 2022 )). These findings raise questions about the broad applicability of oxytocin as a treatment for PTSD, though a more positive take is that oxytocin may be suited to more personalized medicine.…”

Stress and Hypertension in War and Covid-19 Conditions

“…Основу сучасних підходів до діагностики та корекції психологічних наслідків війни становить концепція відстрочених реакцій на травматичний стрес [7]. Особливу увагу приділяють посттравматичному стресовому розладу (ПТСР), що призводить до частого співіснування з іншими захворюваннями, знижує якість життя пацієнтів та потребує високих щорічних витрат на лікування [8]. З часом нас очікує збільшення числа нових випадків посттравматичного стресу через поточну глобальну ситуацію -пандемію COVID-19 і збройні конфлікти, що продовжуються [7].…”