Progress in rectal cancer staging and treatment

Pramateftakis, Manousos-Georgios; Kanellos, D.; Vrakas, G.; Tsachalis, T.; Makrantonakis, Apostolos; Koukouritaki, Zambia; Kanellos, Ioannis

doi:10.1007/s10151-010-0619-7

Cited by 15 publications

(9 citation statements)

References 8 publications

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“…4 Besides the importance of screening, diagnostics, and multidisciplinary treatment of CRC, oncologically adequate and healthy tissue sparing surgery remains the cornerstone of improved survival. 5,6 To determine a total tumor resection intraoperatively, pathologic review of the removed specimen is needed, which increases the duration of the operation and is sometimes not constantly available. 7 Traditional imaging modalities are not suitable to adequately localize oncologically negative resection margins in a real-time intraoperative setting.…”

Section: Introductionmentioning

confidence: 99%

Synergy of Fluorescence and Near-Infrared Spectroscopy in Detection of Colorectal Cancer

Ehlen

Zabaryło

Speichinger

et al. 2019

Journal of Surgical Research

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Magnetic resonance spectroscopy a b s t r a c tBackground: Colorectal cancer is one of the most common malignancies worldwide. There is an urgent need for simple and fast methods to improve tumor detection in the diagnostic and intraoperative setting to avoid complications and provide objective information in distinguishing malignant and benign colorectal tissue. Optical spectroscopy methods have recently shown a great potential for this discrimination in different organs. Materials and methods:In this pilot study, fluorescence emission spectra (excitation: 473 nm) and diffuse reflectance spectra (DRS) of normal and tumor tissues from resected colorectal cancer specimen were measured using fiber optical probes in an ex vivo setting, and the data were subjected to multivariate analysis.Results: Substantial spectral differences were found in the fluorescence and DRS spectra of colorectal cancer tissue in comparison to benign tissue. The diagnostic potential of a multimode optical system combining both spectroscopic methods was investigated by mathematical combination. Compared with the individual techniques, a higher sensitivity of the joint DRS-fluorescence optical system in the discrimination between malignant and benign colorectal tissue could be observed. Conclusions:In the pilot study presented herein, a quick and reliable method to differentiate malignant and benign colorectal tissue ex vivo with different spectroscopic techniques using spectral fiber probes could be established. Joint fluorescence and near-infrared spectroscopy had a higher sensitivity in tissue discrimination and showed to be a promising combination of two spectroscopic methods. Further studies using the synergic effect of fluorescence and DRS spectroscopy are needed to transfer these findings into the in vivo situation. ª

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Section: Introductionmentioning

confidence: 99%

Synergy of Fluorescence and Near-Infrared Spectroscopy in Detection of Colorectal Cancer

Ehlen

Zabaryło

Speichinger

et al. 2019

Journal of Surgical Research

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“…Traditional therapeutic regimens, cytoreductive surgery plus chemotherapy or radiotherapy were applicable for CRC cure and remission [4]. In addition, quality control in surgery and oncological treatment plays a pivotal role in colon cancer therapy, suggesting thqt the combination of modern surgery and new cytostatic agents might contribute to improved five-year survival rates [5]. Heterogeneous molecular mechanisms of CRC were responsible for the difficulty of subsequent treatment [6].…”

Section: Introductionmentioning

confidence: 99%

Zinc finger of the cerebellum 5 promotes colorectal cancer cell proliferation and cell cycle progression through enhanced CDK1/CDC25c signaling

et al. 2021

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Introduction: Colorectal cancer (CRC), mostly caused by external or environmental factors, is the third most common and lethal cancer worldwide. Although a large number of investigations have been carried out to reveal the evolution of CRC, the underlying mechanisms of CRC remain unclear. Material and methods: Expression of zinc finger of the cerebellum 5 (ZIC5) in CRC tissues and cell models was measured by qRT-PCR and IHC. Cell transfection was carried out for ZIC5 overexpression or knockdown. The MTT assay was applied to examine the capacity of glioma cell proliferation. Wound healing assay and tumor invasion assay were used to test the capacity of glioma cell migration and invasion respectively. Cell cycle analysis and western blot were used to verify the apoptosis rates of CRC cells upon ZIC5 overexpression or downregulation. A further tumor Xenograft study was used to examine the effects of ZIC5 on tumor malignancy in vivo. Results: Cell models using HCT116 and SW620 cells were established to study the ZIC5 function upon ZIC5 overexpression of knockdown. Consistently, we discovered that ZIC5 also significantly increased in Chinese CRC patients. In addition, ZIC5 promoted CRC cell proliferation through increasing the proportion of cells maintained in the S phase. ZIC5 overexpression facilitated the capacity of CRC cell migration and invasion. Inhibition of ZIC5 mitigated such malignant effects. Conclusions: Collectively, investigations of the ZIC5 in CRC provided a new insight into CRC diagnosis, treatment, prognosis and next-step translational therapeutic developments from bench to clinic.

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“…Some patients respond to neoadjuvant CRT with pathological complete response (pCR) in approximately 20% of casses 1 . Multimodal treatment for rectal cancer includes: introducing effective surgery (total mesorectal excision), neoadjuvant radiotherapy, and modern cytotoxic chemotherapy 2 .…”

Section: Introductionmentioning

confidence: 99%

Complete histopathological regression in rectal cancer after neoadjuvant chemoradiotherapy and sphincter preserving surgical treatment

et al. 2018

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Background/Aim. Multimodal approach to locally advanced rectal cancer treatment results in better disease outcome. Preoperative chemoradiotherapy improves disease local control, reduces risk of local recurrence and in the majority of patients with complete or substantial regression of the tumors significantly improves survival rates. According to the literature data, approximately 20% of patients had achieved complete histopathological response (pCR) after neoadjuvant chemoradiation therapy. The aim of this study was to evaluate overall survival in rectal cancer patients treated with preoperative chemoradiotherapy and sphincter preserving surgery. Methods. This retrospective study included 191 patients. Patients received preoperative radiation therapy and chemotherapy-chemoradiation therapy (CRT) followed by operation that favorized sphincter preservation with total mesorectal excision (TME) from June 2000 until December 2010. Diagnosis was established according to the following algorithm: patient history, digital rectal examiantion, colonoscopy with biopsy and histopathology verification, and preoperative clinical staging. Patients with tumors located below promontorium were included in the study and patients with metastatic disease and local recurrence were excluded from the study. For tumors located below the promontorium

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Progress in rectal cancer staging and treatment

Cited by 15 publications

References 8 publications

Synergy of Fluorescence and Near-Infrared Spectroscopy in Detection of Colorectal Cancer

Synergy of Fluorescence and Near-Infrared Spectroscopy in Detection of Colorectal Cancer

Zinc finger of the cerebellum 5 promotes colorectal cancer cell proliferation and cell cycle progression through enhanced CDK1/CDC25c signaling

Complete histopathological regression in rectal cancer after neoadjuvant chemoradiotherapy and sphincter preserving surgical treatment

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