Progress in research of intestinal microbiota related short chain fatty acids

Li, Cui-Ru; Peng, Maijiao; Tan, Zhoujin

doi:10.11569/wcjd.v30.i13.562

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…Acetic acid, propionic acid, and butyric acid are the most abundant SCFAs in the intestine. As one of the primary metabolites of the intestinal microbiota, SCFAs can lower intestinal pH to a certain extent, thereby inhibiting the viability of pathogenic microbiota from promoting intestinal microecological balance and maintaining the integrity of the intestinal mucosal barrier ( Li C. et al, 2022 ). It can also inhibit the expression of inflammatory factors or alleviate inflammation ( Ran et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Dose of sucrose affects the efficacy of Qiweibaizhu powder on antibiotic-associated diarrhea: Association with intestinal mucosal microbiota, short-chain fatty acids, IL-17, and MUC2

Xiao

Deng

et al. 2023

Front. Microbiol.

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IntroductionDue to the poor taste of Qiweibaizhu powder (QWBZP), patients have difficulty taking medicine, which leads to poor compliance and limits clinical use to a certain extent. In the trend of restricting sugar intake, sweeteners have gained massive popularity, among which sucrose is a commonly used sweetener in preparations. This study aimed to investigate the effect of different sucrose dose addition with antibiotic-associated diarrhea (AAD) by intervened QWBZP on intestinal mucosal microbiota.MethodsThirty specific-pathogen-free (SPF) Kunming (KM) male mice were randomly divided into normal group (N), natural recovery group (M), QWBZP group (Q), low dose sucrose group (LQ), medium dose sucrose group (MQ), and high dose sucrose group (HQ). Subsequently, 16S rRNA amplicon sequencing and GC-MS techniques were used to analyze the intestinal mucosal microbiota and short-chain fatty acid (SCFAs) in intestinal contents, respectively, and enzyme-linked immunosorbent assay was used to determine mucin 2 (MUC2) and interleukin 17 (IL-17).ResultsCompared with the Q group, the results showed that with the increase of sucrose dose, the intestinal microbial structure of mice was significantly altered, and the intestinal microbial diversity was elevated, with the poor restoration of the intestinal biological barrier, decreased content of SCFAs, high expression of inflammatory factor IL-17 and decreased content of mucosal protective factor MUC2. In conclusion, we found that the addition of sucrose had an effect on the efficacy of the AAD intervented by QWBZP, which was less effective than QWBZP, showing a certain dose-response relationship. In this experiment, it was concluded that the addition of sucrose might also further lead to intestinal inflammation and the disruption of the intestinal mucosal barrier, and the production of metabolites SCFAs.DiscussionThe addition of sucrose might also further lead to intestinal inflammation and the disruption of the intestinal mucosal barrier, and the production of metabolites SCFAs. However, these findings still need to be verified in a more extensive study. The effect of adding the sweetener sucrose on the efficacy of Chinese herbal medicine in treating diseases also still needs more research.

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Section: Discussionmentioning

confidence: 99%

Dose of sucrose affects the efficacy of Qiweibaizhu powder on antibiotic-associated diarrhea: Association with intestinal mucosal microbiota, short-chain fatty acids, IL-17, and MUC2

Xiao

Deng

et al. 2023

Front. Microbiol.

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“…SCFAs play a pivotal role in maintaining overall body health through various physiological functions. 25 The contents of four SCFAs in feces from three groups were calculated according to the corresponding standard curve (Table S3 †). As shown in Table 2, the total content of four SCFAs in the RJ group (18.10 μg mg −1 ) was more than that of the OC group (17.08 μg mg −1 ).…”

Section: Royal Jelly Promotes the Production Of Scfas In The Fecesmentioning

confidence: 99%

“…They not only play an essential role in maintaining water and electrolyte balance but also significantly impact the regulation of gut microbiota balance, improvement of intestinal function, anti-inflammation processes, and so on. 25,48 Aging is typically accompanied by a decline in SCFAs levels. 5 A significant decrease in acetic acid, isobutyric acid, butyric acid, isovaleric acid, and valeric acid contents in feces from twenty-month-old mice compared with four-month-old mice has been previously reported, and revealed that Coprococcus and Ruminococcus may be key bacteria affecting SCFAs production, and monitor and delay the aging process.…”

Section: Papermentioning

confidence: 99%

Long-term administration of royal jelly regulates age-related disorders and improves gut function in naturally aging mice

Chen,

Zhao,

Zhang

et al. 2024

Food Funct.

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“…For efficacy criteria for PD-associated constipation, 3 studies evaluated SBMs. [22,23,28] Six studies investigated pre-and post-treatment differences in PAC-QOL. [22,23,27,29,31,32] Four studies documented the extent to which CCS changed.…”

Section: Basic Characteristics Of Eligible Studiesmentioning

confidence: 99%

Acupuncture for constipation in Parkinson’s disease: A systematic review and meta-analysis of randomized controlled trials

Li,

Niu,

Yang

et al. 2024

Medicine

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Background: Parkinson’s disease (PD) is the second most common neurological disease worldwide, and there is a potential interaction between PD and constipation. PD constipation often causes significant trouble for patients and seriously affects their quality of life. Acupuncture is widely used for treating constipation and has been clinically proven. However, it is unclear whether the current evidence is sufficient to support acupuncture to improve PD constipation. Methods: We searched the Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, China National Knowledge Infrastructure, Wan Fang Data Knowledge Service Platform, and Chinese Scientific Journal Database (VIP database) for randomized controlled trials from inception through July 1, 2023. Randomized controlled trials (RCTs) included acupuncture, sham acupuncture, and medication for PD constipation. Stata 16.0 software and Cochrane RoB2.0 were used for data processing and migration risk analysis. Results: The 11 studies included a total of 960 patients. The results showed that acupuncture or acupuncture combined with conventional treatment seemed to have advantages in improving complete spontaneous bowel movements (WMD: 1.49, 95% CI: 0.86, 2.11; P < .00001), Patient-Assessment of Constipation Quality of Life questionnaire (WMD: −11.83, 95% CI: −15.67, −7.99; P < .00001), the chronic constipation severity scale (CCS) (SMD: −0.99, 95% CI: −1.40, −0.58; P < .01), and c(RRP) (WMD: 2.13, 95% CI: 0.44, 3.82; P < .05). Conclusion: The present results show that compared with conventional treatment, acupuncture combined with conventional treatment seems to increase the number of spontaneous defecations in PD patients, improve quality of life, increase rectal resting pressure, and alleviate the severity of chronic constipation. Thus, acupuncture has the potential to treat PD constipation. However, due to the study’s limitations, higher-quality RCTs are needed for verification.

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Progress in research of intestinal microbiota related short chain fatty acids

Cited by 6 publications

References 40 publications

Dose of sucrose affects the efficacy of Qiweibaizhu powder on antibiotic-associated diarrhea: Association with intestinal mucosal microbiota, short-chain fatty acids, IL-17, and MUC2

Dose of sucrose affects the efficacy of Qiweibaizhu powder on antibiotic-associated diarrhea: Association with intestinal mucosal microbiota, short-chain fatty acids, IL-17, and MUC2

Long-term administration of royal jelly regulates age-related disorders and improves gut function in naturally aging mice

Acupuncture for constipation in Parkinson’s disease: A systematic review and meta-analysis of randomized controlled trials

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