Progress in research on applying Sijunzi Decoction (四君子汤) in treating digestive malignant tumor

Wu, Bin; Xuan, Zheng-Rong

doi:10.1007/s11655-007-0156-z

Cited by 26 publications

(14 citation statements)

References 2 publications

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“…According to clinical studies performed over the past few decades, SJZD has been used to treat patients with chronic gastritis or chronic atrophic gastritis, nausea, vomiting and diarrhoea (Liu, Yang, & Cai, ; Yu et al, ). Moreover, SJZD has been shown to control tumor progression, prolong patients’ lives, improve their quality of life (Guo & Zhang, ), prevent recurrence and metastasis in postoperative patients (Huang, Xi‐Hua, & Chen, ; Liang, Zhang, & Cai, ), and exert potential effects on immune system activation (Liu et al, ) and tumor therapy (Wu & Xuan, ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Sijunzi decoction in rat plasma after oral administration using ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry

Shao

et al. 2018

Biomedical Chromatography

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Sijunzi decoction (SJZD) is one of the most well-known traditional Chinese herbal formulations. This study elucidates the pharmacokinetics of SJZD in rat plasma after the administration of a single oral dose of 3 mL/kg using ultra-high-performance liquid chromatography electrospray ionization quadrupole-time of flight mass spectrometry (UHPLC-ESI-Q-TOF/MS) with bergapten as an internal standard. The separation was performed on an Agilent Zorbax Eclipse Plus C column (2.1 × 50 mm, 1.8 μm) by elution with acetonitrile and water (containing 0.1% formic acid) at a flow rate of 0.3 mL/min. Electrospray ionization in positive and negative ion modes was used to quantify six compounds, with monitored ion m/z values of 249.1397 [M + H] and 529.3857 [M + H] for atractylenolide III (ATL-III) and pachymic acid (PA), respectively, and m/z of 1107.6638 [M - H] , 991.5746 [M - H + HCOO] , 821.3714 [M - H] , 469.3315 [M - H] for ginsenoside Rb Re, glycyrrhizic acid (GL), and glycyrrhetinic acid (GA), respectively. The calibration curves for ginsenoside Rb , Re, ATL-III, PA, GL and GA were 0.0015-0.75, 0.001-0.5, 0.0004-0.2, 0.003-0.9, 0.0015-0.3 and 0.001-1.5 μg/mL, respectively. The intra- and inter-day precisions (RSD) were <14.3%. The rapid, sensitive and specific UHPLC-ESI-Q-TOF/MS method developed and validated in this study was successfully applied to the simultaneous determination of the six components of SJZD using rat plasma for pharmacokinetic studies after oral administration.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Sijunzi decoction in rat plasma after oral administration using ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry

Shao

et al. 2018

Biomedical Chromatography

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“…Modern pharmacological studies show that this prescription affects several other physiological functions such as improving gastrointestinal function [5], strengthening the immune system [6, 7], improving bone marrow hematopoietic function, and speeding up the production of red blood cells. This prescription can also be used for the treatment of malignant tumors of the digestive tract [8]. Xiao and Yang found that Si-Jun-Zi Decoction could improve the immune function and quality of life and reduce the side effects of chemotherapy in patients with colorectal cancer undergoing chemotherapy [7].…”

Section: Introductionmentioning

confidence: 99%

Si‐Jun‐Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis

Cui

Zhou

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Intestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to replenish qi and invigorate the functions of the spleen. Modern pharmacological studies show that this prescription can improve gastrointestinal function and strengthen immune function. In this study, we investigated the effects of a famous Chinese herbal formula, Si-Jun-Zi Decoction, on the restoration of intestinal function after the relief of obstruction in a rabbit model. We found that Si-Jun-Zi Decoction could reduce intestinal mucosal injury while promoting the recovery of the small intestine. Further, Si-Jun-Zi Decoction could regulate the intestinal immune system. Our results suggest that Si-Jun-Zi Decoction promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis. Our observations indicate that Si-Jun-Zi Decoction is potentially a therapeutic drug for intestinal obstruction.

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“…Clinically, SJZD has been used to treat peptic or gastric ulcer and disorders of the spleen (11). A clinical study has shown that SJZD improves the postoperative survival of patients with gastric carcinoma (12). One study demonstrated that SJZD effectively inhibited the growth of tumors in nude mice bearing SGC-7901 xenografts (13).…”

Section: Introductionmentioning

confidence: 99%

Sijunzi decoction‑treated rat serum induces apoptosis of side population cells in gastric carcinoma

et al. 2017

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Abstract. Sijunzi decoction (SJZD) is a traditional Chinese herbal medicine. Previous studies have indicated that SJZD exhibits antitumor activity. However, the underlying molecular mechanism has not been fully elucidated. To explore the antitumor mechanism of SJZD, the effects of serum from rats treated with SJZD on the proliferation of MKN-28 and HGC-27 gastric carcinoma cell lines were systematically investigated. It was found that SJZD-treated rat serum significantly inhibited the growth of MKN-28 and HGC-27 cells in vitro. The results obtained from a colony formation assay showed that SJZD-treated rat serum decreased the colony formation ability of MKN-28 and HGC-27 cells. The apoptosis rate in MKN-28 and HGC-27 cells was also increased following treatment with SJZD-treated rat serum. Flow cytometry with cell sorting revealed the presence of side population (SP) cells in MKN-28 and HGC-27 cells though Hoechst 33342 staining, and verapamil reduced the SP percentage. Further analysis showed that SJZD-treated rat serum promoted the apoptosis of SP cells in MKN-28 and HGC-27 cell lines by upregulating Bax, caspase-3 and PARP and downregulating bcl-2. These data revealed the therapeutic effect of SJZD-treated rat serum on gastric carcinoma. Following the preliminary identification of the inhibitory effect on the growth of gastric cancer cells in vitro, the growth inhibitory effect of SJZD-treated rat serum on SP cells was confirmed, and this inhibition particularly involved the induction of cell apoptosis.

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Progress in research on applying Sijunzi Decoction (四君子汤) in treating digestive malignant tumor

Cited by 26 publications

References 2 publications

Pharmacokinetics of Sijunzi decoction in rat plasma after oral administration using ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry

Pharmacokinetics of Sijunzi decoction in rat plasma after oral administration using ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry

Si‐Jun‐Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis

Sijunzi decoction‑treated rat serum induces apoptosis of side population cells in gastric carcinoma

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