Progress in Research on the Effect of Melatonin on Postoperative Cognitive Dysfunction in Older Patients

Wei, Yuqing; Zhang, Chun‐Lu; Wang, Danyang; Cheng-ping, Wang; Sun, Lin; Chen, Peng

doi:10.3389/fnagi.2022.782358

Cited by 17 publications

(11 citation statements)

References 56 publications

(70 reference statements)

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“…Univariate logistic regression analysis showed that age, coronary heart disease, cerebral infarction, ASA physical status classification, education level, preoperative MMSE and MOCA scores were predictors of POCD, which were similar to those previously reported. 9 , 23 , 33 , 34 , However, only age and duration of hospitalization were found to be independent risk factors for POCD in multivariate regression analysis. This indicated that the incidence of POCD increased with age and the duration of hospitalization increased, similar to the finding reported previously.…”

Section: Discussionmentioning

confidence: 81%

“…This indicated that the incidence of POCD increased with age and the duration of hospitalization increased, similar to the finding reported previously. 33 , 34 This may be because with the increase in age, the functions of various organs in the body of elderly patients tend to degenerate, the reserve capacity decreases, and the ability to withstand trauma such as surgery and anesthesia decreases. 35 The pharmacodynamics and pharmacokinetics of elderly patients may be decreased, making them more sensitive to drugs.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair

Li¹,

Han²,

Yang³

et al. 2023

DDDT

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Purpose This study aimed to explore the effects of different injection rates of propofol on postoperative cognition in elderly patients undergoing laparoscopic inguinal hernia repair. Methods A total of 180 elderly patients who planned to undergo laparoscopic inguinal hernia repair were randomly divided into three groups: slow injection of propofol (V S -Group, 30 mg kg −1 h −1 ); medium injection of propofol (V M -Group, 100 mg kg −1 h −1 ) or fast injection of propofol (V F -Group, 300 mg kg −1 h −1 ). Propofol was induced by microinfusion pump, and the depth of anesthesia was monitored by bispectral index (BIS). Propofol and remifentanil were continuously infused during anesthesia maintenance and adjusted according to BIS. The primary outcome was the use of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) to measure the incidence of postoperative cognitive decline (POCD) in elderly patients on the first and seventh postoperative day. Secondary outcomes included induced dose of propofol, incidence of burst suppression and maximum electroencephalographic (EEG) effect of propofol (BIS-min) during induction. Results The incidence of POCD on the first and seventh day postoperatively was similar among the three groups (P > 0.05). However, with the increase of propofol injection rate, induced dose of propofol, incidence of burst suppression and BIS-min during induction, the number of patients requiring vasoactive agents were significantly increased ( P < 0.001). Multivariate regression analysis showed that the brief duration of burst suppression during induction did not affect the occurrence of POCD, while age and duration of hospitalization were risk factors for POCD. Conclusion For elderly patients undergoing laparoscopic inguinal hernia repair, lowering the injection rate of propofol (such as 30 mg kg −1 h −1 ) cannot decrease the incidence of early POCD, but reduces induction dose of propofol and use of vasoactive drugs, making the patient’s hemodynamics more stable.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair

Li¹,

Han²,

Yang³

et al. 2023

DDDT

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show abstract

“…Other studies showed that surgical trauma was one of the high risk factors for the cognitive dysfunction [ 12 ]. This was because that surgical trauma could cause the release of inflammatory cytokines, which played an important role in the development of cognitive dysfunction [ 13 ]. To investigate whether surgical trauma could affect the cognitive function in rats, in this study, SD rats, aged 18 months, underwent splenectomy to simulate the conditions of postoperative cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Study on the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Inflammation in Aged Rats

Hou

Zhang

Deng

2022

Contrast Media & Molecular Imaging

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Objective. The aim of this study is to investigate the effect of dexmedetomidine on cognitive dysfunction and inflammatory cytokines in the hippocampus after surgery in aged rats. Methods. A total of 30 healthy male Sprague Dawley rats were divided into control group, sham group, and dexmedetomidine group. A splenectomy rat model was established and dexmedetomidine was intraperitoneally injected before operation. The cognitive function of rats was examined by Morris Water-Maze Test, open field experiment, and passive avoidance memory test. And the expression levels of IL-6, IL-1β, and TNF-α in the hippocampus were examined by ELISA. Results. The escape latency for 5 continuous days in dexmedetomidine group was significantly decreased comparing with control group (all P < 0.05 ). The number of times of swimming and the percentage of swimming time in dexmedetomidine group were significantly more than those in control group (all P < 0.05 ). What is more, rats in dexmedetomidine group had the decreased time of stay in the central square and the increased number of standing times in comparison with the control group, and the statistical differences were found (all P < 0.05 ). Compared with the control group, dexmedetomidine intraperitoneally injected before surgery could significantly inhibit the expression levels of IL-6, IL-1β, and TNF-α in the hippocampus, and there were statistical differences (all P < 0.05 ). Conclusion. Dexmedetomidine could significantly relieve the postoperative cognitive dysfunction in aged rats. The mechanism may be associated with the decreased inflammatory cytokines in the hippocampus.

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“…52 In the human body, melatonin is a neuroregulatory hormone synthesized by pineal cells, which has the functions of regulating circadian rhythm, antioxidation, antiinflammation, scavenging free radicals, and immune regulation. 53 This catalytic protocol could allow the trifluoromethylation of various heteroarenes, including imidazopyridines, indoles, and thiophenes. The proposed mechanism involved Ni I -induced single-electron reduction of CF 3 I to generate the CF 3 radical.…”

Section: Late-stage Trifluoromethylation Of Arenes and Heteroarenes O...mentioning

confidence: 99%

A straightforward access to trifluoromethylated natural products through late-stage functionalization

Peng

et al. 2023

Nat. Prod. Rep.

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Progress in Research on the Effect of Melatonin on Postoperative Cognitive Dysfunction in Older Patients

Cited by 17 publications

References 56 publications

Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair

Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair

Study on the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Inflammation in Aged Rats

A straightforward access to trifluoromethylated natural products through late-stage functionalization

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