“…However, several studies have reported the potential and benefits derived from the use of hybrid systems for fault detection and diagnosis, combining fundamental process knowledge with data-base models (Van Lith et al, 2003;Venkatasubramanian et al, 2003c;Nandi et al, 2004;Van Sprang et al, 2005;Thornhill and Horch, 2007;Yang and Xiao, 2012), especially when considering large-scale industrial situations. From a model-based perspective, it has been shown that the use of hierarchical system decomposition, as a qualitative model-based reasoning tool, can provide effective modularity for structuring large-scale diagnostic knowledge bases (Prasad et al, 1998).…”