Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

Abstract

Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover a systematic assessment and discuss the spray-drying of diverse protein pharmaceuticals and excipients included therein, solvent systems applicable to these formulations, equipment used and, respective process parameters. Further, key quality aspects of spray-dried protein solids are discussed. Based on the overall trends, we present a concise perspective into the future of protein pharmaceuticals spray-drying.

Local Treatment of Non-small Cell Lung Cancer with a Spray-Dried Bevacizumab Formulation

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Thermodynamic Balance vs. Computational Fluid Dynamics Approach for the Outlet Temperature Estimation of a Benchtop Spray Dryer

“…From its invention in 1872 by Samuel Percy, this technology has been further developed to produce powders with improved properties while maintaining relatively low production costs [1]. Over the past 15 years, spray drying has been successfully applied in the manufacturing of pharmaceutical proteins, and its use has been firmly established as a producer of amorphous solid dispersions, enhancing the bioavailability of poorly soluble drugs [6,7]. Moreover, it is useful for drugs for controlling taste-masking or producing dosage forms that can be administered by inhalation [7].…”

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“…In recent years, a great interest was given to the research on the design of new polymeric materials with adapted properties and multiple functionalities, from technology to biomedical and environmental applications [1][2][3]. In this context, the physical mixing of two polymers or more represents simplest conceptual way to achieve the desired properties of new materials.…”

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