“…This review is focused on the design, synthesis, bio-pharmacological evaluation, and data analysis of a large number of coumarin derivatives, mainly developed in our group, as monoamine oxidase (MAO), cholinesterase (ChE), and aromatase (AR) inhibitors, and as multitarget agents addressing neurodegenerative diseases (NDs). Coumarin derivatives studied by other groups will be also taken into account, to expand the analysis of the structure–activity relationships (SARs), but not in an extensive/comprehensive way, most of them being already quoted in a recent book [ 1 ] and exhaustive reviews [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”