A two‐year study of estrogen replacement therapy was conducted on 1,200 postmenopausal women. Computerized data concerning the effect on 20 common symptoms showed 95 per cent relief during an appropriate regimen of estrogen‐progesterone therapy. The improvement in the ability to enjoy life counteracted any reluctance to undergo hormone‐induced withdrawal bleeding in the women with an intact uterus. There was no laboratory or clinical evidence that the treatment caused cancer. The benefits of continuous cyclic hormone therapy for estrogen‐deficient women far outweigh the possible dangers.