Progress in the Preclinical and Clinical Study of Resveratrol for Vascular Metabolic Disease

Fan, Dongxiao; Liu, Chenshu; Zhang, Zhongyu; Huang, Kan; Wang, Tengyao; Chen, Sifan; Li, Zilun

doi:10.3390/molecules27217524

Cited by 17 publications

(6 citation statements)

References 122 publications

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“…In the past, resveratrol may have promoted atherosclerosis in rabbits with hypercholesterolemia ( 43 ). However, resveratrol currently has gained increased attention because of its beneficial effects on improving metabolism in endothelial and vascular smooth muscle cells in many preclinical and clinical studies on atherosclerosis, metabolic disease, hypertension, and ischemia ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial

Hattori,

Minami,

Omae

et al. 2024

Front. Nutr.

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BackgroundCarotid artery stenosis or occlusion (CASO) is a major cause of vascular cognitive impairment (VCI). There is currently no effective treatment for VCI induced by CASO. Resveratrol, a type of polyphenol, improves cognitive performance in rat CASO models via pleiotropic effects. Furthermore, we previously reported the longevity gene, SIRT1, which can be activated by resveratrol, improves cognitive and cerebral blood flow impairment in mouse CASO models by activating endothelial nitric oxide synthase. However, clinical evidence remains limited.MethodsThe REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP) trial is a randomized, double-blind, placebo-controlled trial involving patients with asymptomatic CASO. Each participant will receive either 150 mg/day of resveratrol or a placebo for 35 weeks. The primary objective is to determine whether resveratrol improves cognitive impairment, as assessed using the Alzheimer’s disease Assessment Scale–cognitive subscale 13. One of our secondary objectives is to determine whether resveratrol improves cerebral hemodynamic impairment as assessed via 15O-gas positron emission tomography. We will recruit 100 patients (50 per group).DiscussionThe REVAMP trial may provide valuable insights into new therapeutic options, as multitarget neuroprotection could potentially improve cognitive function along with enhancements in cerebral hemodynamic status in patients with asymptomatic CASO.Clinical trial registration: The REVAMP trial was prospectively registered in the Japan Registry of Clinical Trials (jRCTs051230013) on April 13, 2023.

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Section: Discussionmentioning

confidence: 99%

REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial

Hattori,

Minami,

Omae

et al. 2024

Front. Nutr.

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“…Current appraisals have determined that RSV has a valuable influence on repairing metabolism in endothelial cells and vascular smooth muscle cells. The regulation of cell metabolism activity is connected to the suppression of glucose uptake, inhibition of glycolysis, prevention against damages caused by fatty acids through stimulation of fatty acid oxidation, reduction in lipogenesis by increasing lipolysis, and elevation of glutamine uptake and synthesis [178]. Vascular smooth muscle cell senescence is a critical element that stimulates the progression of CVDs.…”

Section: Rsv As Vascular Protective Natural Compoundmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Applied Sciences

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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“…The regulation of cell metabolism activity is connected to the suppression of glucose uptake, inhibition of glycolysis, prevention against damages caused by fatty acids through stimulation of fatty acid oxidation, reduction of lipogenesis by increasing lipolysis and elevation of glutamine uptake and synthesis [163]. Vascular smooth muscle cells senescence is a critical element that stimulates the progression of CVDs.…”

Section: Resveratrol As Vascular Protective Natural Compoundmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Preprint

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants, as a defense mechanism, in response to microbial aggression, toxins or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, its properties being evaluated in vitro or in vivo, on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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Progress in the Preclinical and Clinical Study of Resveratrol for Vascular Metabolic Disease

Cited by 17 publications

References 122 publications

REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial

REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial

Resveratrol: A Review on the Biological Activity and Applications

Resveratrol: A Review on the Biological Activity and Applications

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