This study documents the changes in the Land Use/Land Cover (LULC) in the region of saline lakes in north Tunisia, Sahara Desert. Remote sensing data are a valuable data source in monitoring LULC in lacustrine landscapes, because variations in the extent of lakes are visible from space and can be detected on the images. In this study, changes in LULC of the salt pans of Tunisia were evaluated using a series of 12 Landsat 8-9 Operational Land Imager (OLI) and Thermal Infrared (TIRS) images. The images were processed with the Geographic Resources Analysis Support System (GRASS) Geographic Information System (GIS) software. The study area included four salt lakes of north Tunisia in the two regions of the Gulf of Hammamet and Gulf of Gabès: (1) Sebkhet de Sidi el Hani (Sousse Governorate), (2) Sebkha de Moknine (Mahdia Governorate), (3) Sebkhet El Rharra and (4) Sebkhet en Noual (Sfax). A quantitative estimate of the areal extent analysed in this study is 182 km × 185 km for each Landsat scene in two study areas: Gulf of Hammamet and Gulf of Gabès. The images were analysed for the period 2017–2023 on months February, April and July for each year. Spatio-temporal changes in LULC and their climate–environmental driving forces were analysed. The results were interpreted and the highest changes were detected by accuracy assessment, computing the class separability matrices, evaluating the means and standard deviation for each band and plotting the reject probability maps. Multi-temporal changes in LULC classes are reported for each image. The results demonstrated that changes in salt lakes were determined for winter/spring/summer months as detected changes in water/land/salt/sand/vegetation areas. The accuracy of the classified images was evaluated using pixel rejection probability values, which were filtered out using the ‘r.mapcalc’ module of GRASS GIS. The confidence levels were computed and visualised with a series of maps along with the error matrix and measured convergence level of classified pixels. This paper contributes to the environmental monitoring of Tunisian landscapes and analysis of climate effects on LULC in landscapes of north Africa.