Progress in the Synthesis and Applications of 2-Imidazolines

Abstract

As an important class of heterocyclic scaffolds, 2-imidazolines and their derivatives are an important class of molecules. Based on their good reactivity and biological activity, they are widely used in the field of drugs and pharmaceuticals, natural product chemistry, synthetic organic chemistry, coordination chemistry, anticorrosion and homogeneous catalysis. Significant effort has been devoted to the synthesis and applications of such compounds. This review provides a summary of recently developed methods for the preparation of 2-imidazolines, and their latest developments of applications.

Synthesis of CF3-Containing 2-Imidazolines and Imidazoles via a Iodide-Promoted [3 + 2] Cyclization Reaction

“… Moreover, 2-imidazolines have been investigated as ligands and catalysts in the fields of organic reactions . Due to their high importance, versatile methodologies for the synthesis of functionalized 2-imidazolines have been developed (Scheme a), including (1) condensation reactions of ketones or aldehydes with amines, (2) diamination reaction of alkenes, (3) cycloadditions of isocyanides, nitriles, azides, azlactones, or 2H-azirines, and so on . In general, most of these procedures are sufficiently powerful, but they are often required in terms of stepwise reaction, the use of metal catalysts, or employing stoichiometric and even largely excessive promoters.…”

Silver-Catalyzed Synthesis of CF3-Substituted 2-Imidazolines

“…由此可见, 探索咪唑 啉化合物的合成方法尤为重要. 在众多的合成 2-咪唑啉 化合物的方法 [1,13] 中, 除了以乙二胺为原料的传统合成 方法外, 另一个应用最广泛的方法就是亚胺与异氰基乙 酸酯的 Mannich 型的加成/环化串联反应 [14] .…”