Progress in the treatment of drug-loaded nanomaterials in renal cell carcinoma

Li, Jianyang; Wu, Kunzhe; Zhang, Jinmei; Gao, Huan; Xu, Xiaohua

doi:10.1016/j.biopha.2023.115444

Cited by 5 publications

(1 citation statement)

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“…Surgical treatment is the preferred option for managing renal carcinoma, while immunotherapies have shown sensitivity instead of chemotherapy drugs ( Klapper et al, 2008 ; Aggen et al, 2021 ). Currently, the prognosis of targeted drugs that combined to inhibit angiogenesis is unsatisfactory ( Maslov et al, 2022 ; Li et al, 2023 ). Previous studies have shown that renal carcinoma is a malignant tumor that relies on angiogenesis and hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects and underlying mechanism of poly (L-glutamic acid)-g-methoxy poly (ethylene glycol)/combretastatin A4/BLZ945 nanoparticles on Renca renal carcinoma

Chen,

Yin,

Yang

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: The prognosis of advanced renal carcinoma is not ideal, necessitating the exploration of novel treatment strategies. Poly(L-glutamic acid)-g-methoxy poly(ethylene glycol)/Combretastatin A4 (CA4)/BLZ945 nanoparticles (CB-NPs) possess the dual capability of CA4 (targeting blood vessels to induce tumor necrosis) and BLZ945 (inducing M2 macrophage apoptosis), thereby inhibiting tumor growth.Methods: Here, the therapeutic effects and underlying mechanism was explored by CCK-8 cytotoxicity experiment, transwell cell invasion and migration experiment, H&E, western blot analysis, immunohistochemistry, flow cytometry, and other techniques.Results: These results demonstrated that CB-NPs could inhibit the growth of Renca cells and subcutaneous tumors in mice, with an impressive tumor inhibition rate of 88.0%. Results suggested that CB-NPs can induce necrosis in renal carcinoma cells and tissues, downregulate VEGFA expression, promote renal carcinoma cell apoptosis, and reduce the polarization of M2 macrophages.Discussion: These findings offer innovative perspectives for the treatment of advanced renal carcinoma.

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