Progress involving new techniques for liposome preparation

Huang, Zhenjun; Li, Xuan; Zhang, Ting; Song, Yanzhi; She, Zhennan; Li, Jing; Deng, Yihui

doi:10.1016/j.ajps.2014.06.001

Cited by 126 publications

(66 citation statements)

References 25 publications

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“…To formulate liposomal preparations acceptable as pharmaceuticals, some criteria are frequently mentioned to be important (Wagner et al, 2002, Huang et al, 2014: (1) A unimodal narrow-size distribution, (2) a satisfactory chemical and physical stability, (3) a reproducible production process, (4) a high and constant entrapment efficiency, (5) a retained, depot-type drug-release from the vehicle is often anticipated, and (6) a production procedure that facilitates sterile and pyrogen-free products. The relatively small number of liposomal products approved for human use so far, relative to the enormous research and development works on liposomes, might be explained by failure to meet any of these criteria, but high cost of the production process, especially on a larger scale, might as well keep products from entering the market (Mozafari, 2005).…”

Section: Resultsmentioning

confidence: 99%

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

Ingebrigtsen

Škalko‐Basnet

Holsæter

2016

Drug Development and Industrial Pharmacy

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Objectives: The objective of the present study was to utilize dual asymmetric centrifugation (DAC) as a novel processing approach for the production of liposomes-in-hydrogel formulations. Materials and Methods:Lipid films of phosphatidylcholine, with and without chloramphenicol (CAM), were hydrated and homogenized by DAC to produce liposomes in the form of vesicular phospholipid gels with a diameter in the size range of 200-300 nm suitable for drug delivery to the skin. Different homogenization processing parameters were investigated along with the effect of adding propylene glycol (PG) to the formulations prior to homogenization. The produced liposomes were incorporated into a hydrogel made of 2.5 % (v/v) soluble β-1,3/1,6-glucan (SBG) and mixed by DAC to achieve a homogenous liposomes-inhydrogel-formulation suitable for topical application.Results and Discussion: CAM-containing liposomes with a vesicle diameter of 282 ± 30 nm and polydispersity index (PI) of 0.13 ± 0.02 were successfully produced by DAC after 50 minutes centrifugation at 3500 rpm, and homogenously (< 4 % content variation) incorporated into the SBG hydrogel. Addition of PG decreased the necessary centrifugation time to 2 minutes and 55 seconds, producing liposomes of 230 ± 51 nm and PI of 0.25 ± 0.04. All formulations had an entrapment efficiency of approximately 50%. Conclusions:We managed to develop a relatively fast and reproducible new method for the production of liposomes-in-hydrogel formulation by DAC.

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Section: Resultsmentioning

confidence: 99%

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

Ingebrigtsen

Škalko‐Basnet

Holsæter

2016

Drug Development and Industrial Pharmacy

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“…Another popular route for the encapsulation of hydrophobic NPs within lipid bilayers is the reverse phase evaporation (RPE) process . RPE is performed through the addition of water to an organic solvent containing dissolved lipids and the NPs, before gradually evaporating away the organic solvent to produce lipid vesicles with the hydrophobic NPs incorporated within the lipid bilayers …”

Section: Methods and Effects Of Incorporating Inorganic Nps Into Drugmentioning

confidence: 99%

Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

Moorcroft

Jayne

Evans

et al. 2018

Macromolecular Bioscience

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Recently, the combination of metallic nanoparticles (NPs) of Au, Ag, Fe2O3, and Fe3O4 with traditional soft matter drug‐delivery systems has emerged as a promising strategy to achieve site‐specific and controlled release of antimicrobial agents. By harnessing the plasmonic and magnetic properties of inorganic NPs, the disruption of antibiotic‐loaded liposomes, polymersomes, and hydrogels can be remotely triggered by mechanisms such as photo‐ and magneto‐thermal effects, microbubble cavitation, magnetic positioning, and pH‐changes, hence offering significant advantages in improving antibacterial efficacy, reducing side effects, and in overcoming antimicrobial resistance. This review highlights the latest development of stimuli‐responsive antibiotic delivery systems incorporating inorganic NPs. The methods employed for preparation of hybrid inorganic NP‐associated drug‐delivery systems and the effects this has upon the system are discussed. Finally, a detailed exposition of the NP‐mediated triggering mechanisms is provided and pertinent examples of their use in antimicrobial applications are presented.

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“…But now the nano-vesicular approach is being experimented to modulate the formulations. For example, DNA encoding Miscellaneous: 51,52 Experimental studies were carried out for multiple doing of sodium Stibogluconatenano-vesicles was found to be effective against the parasite in liver, spleen and bone marrow as compared to the solution of Sodium Stibogluconate. CONCLUSION: Development of novel surfactant based vesicles of Spanlastics provides a noninvasive tool for delivering the drug to its target site without the need for frequent drug administration.…”

Section: Applications Of Spanlasticsmentioning

confidence: 99%

Untitled

2020

IJPSR

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Drug delivery to targeted sites is restricted by various barriers. The conventional drug delivery systems like tablets, capsules, suspensions, emulsions, elixirs, lotions etc. are being encountered with a number of issues such as poor bioavailability, drug shelf life, drugexcipients incompatibilities and patient in compliance. Thus with the advent of novel drug delivery systems such as liposomes; nanoparticles are proving to be a better option nowadays. As evolution in the drug delivery system, a new system with lesser side effects was introduced in 2011 known as Spanlastics. They are elastic, deformable surfactant-based nanovesicles in which an aqueous solute solution is entirely enclosed. They are shown to be chemically more stable. They provide targeting and controlled release of natural pharmaceutical compounds and have improved several drawbacks of the conventional dosage form. The current review emphasizes the utility of spanlastics, mechanism of penetration, different preparation approaches, their evaluation parameters and applications.

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Progress involving new techniques for liposome preparation

Cited by 126 publications

References 25 publications

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

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