Progress of biomaterials for bone tumor therapy

Abstract

Bone tumors are currently a major clinical challenge. In recent decades, strategies using well-designed versatile biomaterials for the treatment of bone tumors have emerged and attracted extensive research interest. Suitable biomaterials not only facilitate repair for bone defects aroused by surgical intervention but also help deliver antineoplastic drugs to the target site or provide photothermal/magnetothermal therapy to kill bone tumor cells. Thus, the development of biomaterials exhibits a great perspective for future bone tumor treatment. We summarize the recent progress of versatile biomaterials for bone tumor therapy, with an emphasis on photothermal/magnetothermal therapy and drug delivery. With the further understanding and development of biomaterials, multifunctional biomaterials have been proposed for bone tumor treatment. Through the interdisciplinary cooperation from the fields of biomedicine, clinical medicine and engineering, multifunctional biomaterials will perfectly match individual bone defects in the clinic with low cost in the future.

Biomaterial-based strategy for bone tumor therapy and bone defect regeneration: An innovative application option

“…In the clinic, conventional therapies for bone tumors mainly include surgical interventions, chemotherapy, and radiotherapy. Unfortunately, surgical resection often fails to completely eradicate micrometastases, which is likely to result in postoperative recurrence and metastasis (Chen and Yao, 2022). In some cases, bone defects caused by surgery are the main cause of physical disability.…”

Synthetic biodegradable polymer materials in the repair of tumor-associated bone defects

“…The standard clinical treatment strategy for bone cancer involves surgical resection and reconstruction of the involved bone followed by adjuvant radiotherapy or chemotherapy. Surgical resection of bone malignancies can cause bone defects or delayed bone healing, severely affecting the patient’s quality of life ( Isakoff et al, 2015 ; Rojas et al, 2021 ; Chen and Yao, 2022 ). Finding the ideal repair materials has always been a challenge for orthopedic surgeons.…”

Exploration of 2D and 2.5D Conformational Designs Applied on Epoxide/Collagen-Based Integrative Biointerfaces with Device/Tissue Heterogeneous Affinity

“…3−6 The technologies are advancing, but the dazzling novel functions of biointerfaces would always require steady and reliable foundations, which should have not only convincing durability and biological security but also sufficient adhesion to both tissues and devices. 7,8 Current strategies tend to fabricate multiple-layer composite biointerfaces, which contain specialized adhesive layers or solid precipitation layers such as dopamine and hydroxyapatite, to assist immobilized functional layers. 9,10 The layering design could be a convenient way to effectively integrate functions, but common biomaterials like proteins and polysaccharides might be weakened and lose interlayer connections during the loops of immersing, depositing, and drying due to swelling or dissolving natures and different charge properties.…”

“…Biointerfaces are intermediaries that facilitate the combinations and connections between inanimate constructs and animate organisms, which are committed to create the buffer and transition regions between biotic tissues and abiotic devices. , Nowadays, benefiting from progressing material sciences with interdisciplinary approaches, biointerfaces are making impressive breakthroughs that are now available to the interactions and communications of devices to tissues, such as optical and electrical energy conversion, heterogeneous biological delivery, and dynamic infection resistance. − The technologies are advancing, but the dazzling novel functions of biointerfaces would always require steady and reliable foundations, which should have not only convincing durability and biological security but also sufficient adhesion to both tissues and devices. , Current strategies tend to fabricate multiple-layer composite biointerfaces, which contain specialized adhesive layers or solid precipitation layers such as dopamine and hydroxyapatite, to assist immobilized functional layers. , The layering design could be a convenient way to effectively integrate functions, but common biomaterials like proteins and polysaccharides might be weakened and lose interlayer connections during the loops of immersing, depositing, and drying due to swelling or dissolving natures and different charge properties. All these concerns lead to the inspiration to develop integrative biointerfaces that are expected to achieve biocompatibility, bioactivity, biodurability, and heterogeneous affinity to both tissues and devices within one integrative layer.…”