Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering

Zhou, Xian-Bin; Xu, Shiwen; Ye, Liping; Mao, Xin-Li; Chen, Yahong; Wu, Jian-fen; Cai, Yue; Wang, Yi; Wang, Li; Li, Shaowei

doi:10.1016/j.reth.2021.01.003

Cited by 9 publications

(3 citation statements)

References 89 publications

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“…Zhou et al. [ 25 ] used a digital simulator to verify the positional movement of patients with cervical cancer in different bladder volume states and found that the positioning of patients was highly repeated in the bladder filling form. Klein et al.…”

Section: Discussionmentioning

confidence: 99%

Effect of bladder filling status on positioning errors in post-hysterectomy cervical cancer radiotherapy

Ge,

Liu,

Jin

et al. 2023

Annals of Medicine

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Objective: To investigate the effect of different bladder filling states on positioning errors in radiotherapy for cervical cancer and obtain the reference range of bladder filling consistency during radiotherapy. Methods: Patients who underwent postoperative radiotherapy for cervical cancer in Nantong Tumor Hospital from October 2018 to December 2019 were selected. According to the bladder filling deviation, they were divided into group A1 (deviation < 20%) and group B1 (deviation ≥ 20%). The bladder filling variations of the two groups were compared with different positioning errors. Group A2 has a positioning error of <0.4 cm, and group B2 has a positioning error of ≥0.4 cm. The reference range of bladder filling consistency during radiotherapy is obtained by analyzing the composition ratio of different positioning errors of bladder filling deviation. Results: This study included 195 patients with cervical cancer. The error of longitudinal and vertical position in group B1 was significantly higher than that in group A1 (0.50 ± 0.34 vs. 0.26 ± 0.22 cm, p < 0.001, and 0.22 ± 0.17 vs. 0.16 ± 0.12 cm, p < 0.001). Compared with group B2, the absolute deviation of bladder filling in group A2 (54.1% ± 54.4% vs. 25.6% ± 22.7%, p < 0.001) was slight. The chi-square test showed significant differences in the proportion of the positioning state of different bladder filling forms ( χ 2 = 31.006, p < 0.001). In addition, there was a significant difference in the proportion of stability errors in patients with poor stability in different directions ( χ 2 = 118.551, p < 0.001). Conclusion: In patients with cervical cancer fixed in the supine position, a bladder capacity deviation <20% is easier to achieve excellent positioning with, and it can better control the positioning error of radiotherapy and ensure the positioning accuracy of dose distribution to the target area. It can also achieve good tumor treatment effects. This range can be used as a reference for bladder filling consistency in patients with cervical cancer undergoing radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Effect of bladder filling status on positioning errors in post-hysterectomy cervical cancer radiotherapy

Ge,

Liu,

Jin

et al. 2023

Annals of Medicine

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“…According to Guo and Liang (2021), the siphon effect of talent and capital brought on by digital industrialization hampered technical advancement (Guo and Liang, 2021). According to Zhou et al (2021), based on the panel data of Chinese cities from 2011 to 2019, the digital economy significantly increased the GTFP of central cities, but the "siphon effect" hindered the green total factor productivity improvement of peripheral cities (Zhou et al, 2021). Xu and Liu.…”

Section: The Digital Economy-gtfp Nexusmentioning

confidence: 99%

The impact of the digital economy on green total factor productivity in Belt and Road countries: the mediating role of energy transition

Wang

Ren²

2023

Front. Environ. Sci.

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Introduction: The prospective Belt and Road (B&R) Initiative by China must be thoroughly examined by the participating nations in all respects. It is now essential to investigate whether the digital economy of the B&R countries can support green total factor productivity (GTFP). This study examines the connection between green total factor productivity (GTFP) and the digital economy in B&R countries with the aim of providing China with practical recommendations for advancing the initiative.Methods: This study explores 40 B&R countries from 2006 to 2021, calculates the GTFP using the unexpected super-efficient SBM model and the Global Malmquist-Luenberger index method, and constructs the digital economy index using the principal component analysis method. OLS, FMOLS methods, and spatial panel regressions are used to examine the digital economy-GTFP nexus.Results and Discussion: In the selected 40 B&R countries, there is a non-linear relationship between the digital economy and GTFP, and the overall effect of the digital economy on GTFP is negative, implying that the growth of the digital economy will cause a decline in GTFP. Energy transition has mediation effects that can mitigate the negative impact of digital economic growth on GTFP. The spatial spillover effects of the digital economy on the GTFP of neighboring countries are evident. There is also heterogeneity; the digital economy will reduce GTFP in high- and middle-income countries, but the negative effects are not evident in low-income countries. This paper adds to the discussion of the digital economy and green development by drawing different conclusions from previous studies using a variety of regression models, providing a fresh foundation for policy-making.

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“…These studies have focused on extracellular matrix scaffolds, autologous cell suspensions, cell membrane sheets, autologous tissue transplants, etc. [17][18][19]. Autologous epidermal active cell transplantation regeneration technology is a method of transplanting a cell suspension to the wound surface to regenerate the epithelium uniformly and rapidly and avoid scar forma-tion; this approach has been applied in the treatment of burns and skin diseases and has exhibited excellent efficacy [20,21].…”

Section: Introductionmentioning

confidence: 99%

Prevention of Esophageal Stricture after Endoscopic Submucosal Dissection with an Autologous Esophageal Epithelial Cell Suspension: An Animal Study

Su,

Pang,

Wang

et al. 2023

Discovery Medicine

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Background: Severe esophageal stricture decreases patient's quality of life after circumferential endoscopic submucosal dissection (ESD). We aimed to evaluate the efficacy of autologous esophageal epithelial cell suspensions in preventing esophageal stricture after circumferential ESD. Methods: Twelve male mini-pigs underwent circumferential ESD and were randomized into four groups: G1 (control), G2 (esophageal stent), G3 (autologous esophageal epithelial cell suspension), and G4 (autologous esophageal epithelial cell suspension combined with esophageal stent). Post-ESD status was observed in each group, and endoscopy was performed weekly. Esophageal stents were removed 3 weeks after ESD. The esophageal stricture rates and histologic characteristics were assessed 4 weeks after ESD. Results: G1 showed the greatest weight loss (p < 0.05). Dysphagia scores were not significantly different among the groups. The esophageal mucosal stricture rates were 77.7 ± 2.9%, 74.2 ± 1.9%, 69.2 ± 3.8% and 65.9 ± 1.9% in G1-4, respectively; with the highest in G1 (G1 vs. G3, p = 0.005; G1 vs. G4, p = 0.001). The regenerated epithelium lengths were 4.408 ± 1.980 mm, 8.319 ± 0.857 mm, 11.801 ± 2.455 mm and 12.353 ± 1.111 mm in G1-4, respectively. The lowest degree of re-epithelialization was observed in G1, followed by G2, with the highest degrees in G3 and G4 (G1 vs. G3, p = 0.001; G1 vs. G4, p = 0.000). The maximum wound fibrosis thicknesses were 2.546 ± 0.389 mm, 2.136 ± 0.231 mm, 1.126 ± 0.211 mm and 1.131 ± 0.438 mm in G1-4, respectively, with higher degrees in G1 and G2 than in G3 and G4 (G1 vs. G3, p = 0.001; G1 vs. G4, p = 0.001). Conclusions: Autologous esophageal epithelial cell suspensions can promote re-epithelialization and reduce fibrosis, thus decreasing esophageal stricture severity after ESD.

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Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering

Cited by 9 publications

References 89 publications

Effect of bladder filling status on positioning errors in post-hysterectomy cervical cancer radiotherapy

Effect of bladder filling status on positioning errors in post-hysterectomy cervical cancer radiotherapy

The impact of the digital economy on green total factor productivity in Belt and Road countries: the mediating role of energy transition

Prevention of Esophageal Stricture after Endoscopic Submucosal Dissection with an Autologous Esophageal Epithelial Cell Suspension: An Animal Study

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