Progress of HOTAIR-microRNA in hepatocellular carcinoma

Wang, Bing-Rong; Chu, Dong-Xia; Cheng, Meiyu; Jin, Yu; Luo, Haoge; Li, Na

doi:10.1186/s13053-022-00210-8

Cited by 17 publications

(5 citation statements)

References 91 publications

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“…Additionally, the tumor suppressor miR-214-3p was significantly downregulated (8 times) in our HCC group compared to adjacent control tissues. miR-214-3p targets MAP2K3 and MAPK1 to regulate a number of pathways such as FoxO signaling pathway, MAPK signaling pathway and mTOR signaling pathway which is consistent with Wang et al, (2022) study ( 72 ).…”

Section: Discussionsupporting

confidence: 87%

“…Moreover, one of the proposed mechanism of action for miR-214-3p in HCC through the overexpression of Hox transcript antisense intergenic RNA (HOTAIR), which suppresses the expression of adhesion-related integrin which ultimately slows the adherence of HCC cells, and increases metastasis ( 68 – 74 ). The downstream target of HOTAIR, Flotillin 1 (FLOT1), a crucial tumor gene that is connected to the invasion and metastasis of malignancies and can be employed as a stable scaffold when enlisting multi-protein complexes ( 75 ), makes the HOTAIR/miR-214-3p/FLOT1 an important axis of how HCC invades and spreads ( 72 ).…”

Section: Discussionmentioning

confidence: 99%

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miRNome of Child A hepatocellular carcinoma in Egyptian patients

et al. 2023

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IntroductionHepatocellular carcinoma (HCC) has different etiologies that contribute to its heterogeneity. In regards to the number of HCC patients, Egypt ranks third in Africa and fifteenth worldwide. Despite significant advancements in HCC diagnosis and treatment, the precise biology of the tumor is still not fully understood, which has a negative impact on patient outcomes.MethodsAdvances in next-generation sequencing (NGS) have increased our knowledge of the molecular complexity of HCC.Results & discussionIn this research, 16 HCC and 6 tumor adjacent tissues (control) of Child A Egyptian patients were successfully profiled for the expression profile of miRNAs by NGS. Forty-one differentially expressed miRNAs (DEMs) were found by differential expression analysis, with 31 being upregulated and 10 being downregulated. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was then conducted on these differentially expressed miRNAs revealing that Sensitivity and specificity analysis showed that hsa-miR-4488, hsa-miR-3178, and hsa-miR-3182 were unique miRNAs as they are expressed in HCC tissues only. These miRNAs were all highly involved in AMPK signaling pathways. However, hsa-miR-214-3p was expressed in control tissues about eight times higher than in cancer tissues and was most abundant in “pathways in cancer and PI3K-Akt signaling pathway” KEGG terms. As promising HCC diagnostic markers, we here suggest hsa-miR-4488, hsa-miR-3178, hsa-miR-3182, and hsa-miR-214-3p. We further urge future research to confirm these markers' diagnostic and prognostic potential as well as their roles in the pathophysiology of HCC.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

miRNome of Child A hepatocellular carcinoma in Egyptian patients

et al. 2023

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“…They deduced that NR027113 could promote the proliferation and invasion of HCC through PTEN/ PI3K/AKT signaling pathway, and suggested it could be a potential therapeutic target for HCC treatment [62]. HOTAIR (HOX Transcript Antisense RNA) which was found in the HOXC gene on chromosome 12 of the human genome is the first lncRNA found to have a reverse transcription [63][64][65]. HOTAIR is highly expressed in HCC tissue, and it regulates glucose metabolism by activating the mTOR signal transduction pathway, thereby promoting the cell proliferation [66].…”

Section: Effects Of Lncrnas In Hcc On Cell Growth and Proliferationmentioning

confidence: 99%

The role of long non-coding RNA in hepatocellular carcinoma

Liang,

Zhao,

Meng

et al. 2024

Aging

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Hepatocellular carcinoma (HCC) is a prevalent liver malignancy with complex etiology and generally poor prognosis. Recently, long non-coding RNAs (lncRNAs), non-protein-coding RNA molecules exceeding 200 nucleotides, have emerged as pivotal players in HCC, influencing its initiation, progression, invasion, and metastasis. These lncRNAs modulate gene expression at epigenetic, transcriptional, and post-transcriptional levels, actively participating in the pathological and physiological processes of HCC. Understanding the intricate relationship between lncRNAs and HCC is important for improving prognosis and reducing mortality. This review summarizes advancements in elucidating the role of lncRNAs in HCC pathogenesis.

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“…These molecules can have various effects on numerous biological events, including the control of transcription and post-transcription processes, differentiation, development, epigenetic alteration, apoptosis, and cell cycle control [6]. There are several lncRNAs, including HOTAIR [7,8], MALAT1 [9], H19 [10] and ANRIL [11], that could affect the various diseases like cancers.…”

Section: Introductionmentioning

confidence: 99%

The effects of ANRIL polymorphisms on colorectal cancer, tumor stage, and tumor grade among Iranian population

Asadi-Tarani,

Darashti,

Javadi

et al. 2024

Mol Biol Rep

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Background: Colorectal cancer (CRC) is a type of neoplasm, developing in the colon or rectum. The exact etiology of CRC is not well known, but the role of genetic, epigenetic, and environmental factors are established in its pathogenesis. Therefore, the aim of this research was to explore the effects of ANRIL polymorphisms on the CRC and its clinical ndings.Methods and Results: The peripheral blood specimens were collected from 142 CRC patients and 225 controls referred to Milad Hospital, Tehran, Iran. PCR-RFLP method was used to analyze ANRIL rs1333040 rs10757274, rs10757274 and rs1333048 polymorphisms. The ANRIL rs1333040 polymorphism was related to a higher risk of CRC in the co-dominant, dominant, and log-additive models. ANRIL rs10757274, rs10757274, and rs1333048 polymorphisms showed no effect on CRC susceptibility. Haplotype analysis showed a higher risk of CRC in individuals carrying the CGAA haplotype of ANRIL rs1333040/ rs10757274/ rs4977574/rs1333048 polymorphisms and a lower risk of TGGA haplotype compared to TGGC haplotype. The rs1333040 polymorphism was associated with higher TNM stages (III and IV). ANRIL rs10757274 polymorphism was lower in CRC patients over the age of 50 years only in the dominant model. In addition, the rs10757274 was associated with well differentiation in CRC patients.Conclusion, The ANRIL rs1333040 polymorphism was associated with a higher risk of CRC and higher TNM stages. ANRIL rs10757274 polymorphism was associated with the well-differentiated tumor in CRC.

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Progress of HOTAIR-microRNA in hepatocellular carcinoma

Cited by 17 publications

References 91 publications

miRNome of Child A hepatocellular carcinoma in Egyptian patients

miRNome of Child A hepatocellular carcinoma in Egyptian patients

The role of long non-coding RNA in hepatocellular carcinoma

The effects of ANRIL polymorphisms on colorectal cancer, tumor stage, and tumor grade among Iranian population

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