Progress of Imaging in Diabetic Retinopathy—From the Past to the Present

Horie, Shintaro; Ohno‐Matsui, Kyoko

doi:10.3390/diagnostics12071684

Cited by 8 publications

(5 citation statements)

References 102 publications

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“…Recent developments in ultrawide OCT and OCTA equipment has resulted in the ability to image areas measuring 24 × 20 mm, the maximum range currently available among all OCTA devices ( 18 , 19 ). Use of this advanced equipment has shown that the density of the choroidal vessels and the thicknesses of the inner retina segments at the periphery were significantly lower in nonpathological myopic fundi ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Early changes to retinal structure in patients with diabetic retinopathy as determined by ultrawide swept-source optical coherence tomography-angiography

Zeng,

Liu,

et al. 2023

Front. Endocrinol.

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PurposeTo investigate retinal vascular changes in patients with diabetic retinopathy (DR) using the newly developed ultrawide rapid scanning swept-source optical coherence tomography angiography (SS-OCTA) device.MethodsThis cross-sectional, observational study enrolled 24 patients (47 eyes) with DR, 45 patients (87 eyes) with diabetes mellitus (DM) without DR, and 36 control subjects (71 eyes). All subjects underwent 24 × 20 mm SS-OCTA examination. Vascular density (VD) and the thickness of the central macula (CM; 1 mm diameter) and temporal fan-shaped areas of 1–3 mm (T3), 3–6 mm (T6), 6–11 mm (T11), 11–16 mm (T16), and 16–21 mm (T21) were compared among groups. The VD and the thicknesses of the superficial vascular complex (SVC) and deep vascular complex (DVC) were analyzed separately. The predictive values of VD and thickness changes in DM and DR patients were evaluated by receiver operating characteristic (ROC) curve analysis.ResultsThe average VDs of the SVC in the CM and the T3, T6, T11, T16, and T21 areas were significantly lower in the DR than in the control group, whereas only the average VD of the SVC in the T21 area was significantly lower in the DM group. The average VD of the DVC in the CM was significantly increased in the DR group, whereas the average VDs of the DVC in the CM and T21 area were significantly decreased in the DM group. Evaluation of the DR group showed significant increases in the thicknesses of SVC-nourishing segments in the CM and T3, T6, and T11 areas and significant increases in the thicknesses of DVC-nourishing segments in the CM and T3 and T6 areas. In contrast, none of these parameters showed significant changes in the DM group. ROC curve analysis showed that the average VD of the SVC in the CM, T3, and T21 had better ability to predict DR, with areas under the ROC curves (AUCs) of 0.8608, 0.8505, and 0.8353, respectively. The average VD of the DVC in the CM was also predictive of DR, with an AUC of 0.8407.ConclusionsThe newly developed ultrawide SS-OCTA device was better able to reveal early peripheral retinal vascular changes than traditional devices.

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Section: Discussionmentioning

confidence: 99%

Early changes to retinal structure in patients with diabetic retinopathy as determined by ultrawide swept-source optical coherence tomography-angiography

Zeng,

Liu,

et al. 2023

Front. Endocrinol.

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“…Similarly, high-resolution imaging of the iridocorneal angle (ICA) region and the trabecular meshwork (TM) structures are important for the diagnosis of glaucoma [ 5 , 6 ]. High-resolution imaging of the retina is important for the detection and management of diabetic retinopathy and age-related macular degeneration [ 7 , 8 ]. Several ocular imaging techniques and devices have been developed over the past years for the inspection and imaging of various ocular structures [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Bessel Beams in Ophthalmology: A Review

Suchand Sandeep,

Khairyanto,

Aung

et al. 2023

Micromachines

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The achievable resolution of a conventional imaging system is inevitably limited due to diffraction. Dealing with precise imaging in scattering media, such as in the case of biomedical imaging, is even more difficult owing to the weak signal-to-noise ratios. Recent developments in non-diffractive beams such as Bessel beams, Airy beams, vortex beams, and Mathieu beams have paved the way to tackle some of these challenges. This review specifically focuses on non-diffractive Bessel beams for ophthalmological applications. The theoretical foundation of the non-diffractive Bessel beam is discussed first followed by a review of various ophthalmological applications utilizing Bessel beams. The advantages and disadvantages of these techniques in comparison to those of existing state-of-the-art ophthalmological systems are discussed. The review concludes with an overview of the current developments and the future perspectives of non-diffractive beams in ophthalmology.

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“…Fundoscopic imaging is one of the most frequently used methods to assess the interior structures of the eye. In addition to visualizing retinal pathology such as diabetic retinopathy, 1 the resulting images can also be used to measure the distance between retinal structures. For example, in ocular oncology the distances between the optic disk, macula, and tumor are used in radiation treatment planning 2 , 3 ( Fig.…”

mentioning

confidence: 99%

Correction Method for Optical Scaling of Fundoscopy Images: Development, Validation, and First Implementation

Pors,

Haasjes,

van Vught

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose Although fundus photography is extensively used in ophthalmology, refraction prevents accurate distance measurement on fundus images, as the resulting scaling differs between subjects due to varying ocular anatomy. We propose a PARaxial Optical fundus Scaling (PAROS) method to correct for this variation using commonly available clinical data. Methods The complete optics of the eye and fundus camera were modeled using ray transfer matrix formalism to obtain fundus image magnification. The subject's ocular geometry was personalized using biometry, spherical equivalent of refraction (RSE), keratometry, and/or corneal topography data. The PAROS method was validated using 41 different eye phantoms and subsequently evaluated in 44 healthy phakic subjects (of whom 11 had phakic intraocular lenses [pIOLs]), 29 pseudophakic subjects, and 21 patients with uveal melanoma. Results Validation of the PAROS method showed small differences between model and actual image magnification (maximum 3.3%). Relative to the average eye, large differences in fundus magnification were observed, ranging from 0.79 to 1.48. Magnification was strongly inversely related to RSE ( R 2 = 0.67). In phakic subjects, magnification was directly proportional to axial length ( R 2 = 0.34). The inverse relation was seen in pIOL ( R 2 = 0.79) and pseudophakic ( R 2 = 0.12) subjects. RSE was a strong contributor to magnification differences (1%–83%). As this effect is not considered in the commonly used Bennett–Littmann method, statistically significant differences up to 40% (mean absolute 9%) were observed compared to the PAROS method ( P < 0.001). Conclusions The significant differences in fundus image scaling observed among subjects can be accurately accounted for with the PAROS method, enabling more accurate quantitative assessment of fundus photography.

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Progress of Imaging in Diabetic Retinopathy—From the Past to the Present

Cited by 8 publications

References 102 publications

Early changes to retinal structure in patients with diabetic retinopathy as determined by ultrawide swept-source optical coherence tomography-angiography

Early changes to retinal structure in patients with diabetic retinopathy as determined by ultrawide swept-source optical coherence tomography-angiography

Bessel Beams in Ophthalmology: A Review

Correction Method for Optical Scaling of Fundoscopy Images: Development, Validation, and First Implementation

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