Progress of modern agricultural chemistry and future prospects

Jeschke, Peter

doi:10.1002/ps.4190

Cited by 187 publications

(175 citation statements)

References 80 publications

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“…However, the number of known distinct MoAs for fungicides is limited. Approximately 80% of the commercially used fungicides belong to only six MoA groups . Furthermore, the success rate in discovering novel targets for fungicide is declining year by year owing to difficulties arising from stronger regulatory restrictions .…”

Section: Discussionmentioning

confidence: 99%

Metyltetraprole, a novel putative complex III inhibitor, targets known QoI‐resistant strains of Zymoseptoria tritici and Pyrenophora teres

Suemoto

Matsuzaki

Iwahashi

2019

Pest Management Science

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BACKGROUND Metyltetraprole is a new fungicide with a unique tetrazolinone‐moiety and a similar side chain to a known quinone outside inhibitor (QoI), pyraclostrobin. In this study we describe a unique bioactivity of metyltetraprole on QoI‐resistant strains of Zymoseptoria tritici and Pyrenophora teres . RESULTS Metyltetraprole exhibited potent antifungal activity against Ascomycetes; it was especially effective against Z. tritici and P. teres in seedling pot tests. Metyltetraprole was also effective in field tests with QoI‐resistant mutants. Antifungal activity tests using field strains of Z. tritici and P. teres showed that the performance of metyltetraprole was unaltered by QoI, succinate dehydrogenase inhibitor (SDHI), and sterol 14α‐demethylation inhibitor (DMI) resistance. However, the mitochondrial activity test indicated that the compound inhibits the respiratory chain via complex III. CONCLUSION Metyltetraprole is a novel fungicide that is highly effective against a wide range of fungal diseases, including important cereal diseases. Although metyltetraprole most likely inhibits the respiratory chain via complex III, it remains effective against QoI resistant strains. Therefore, metyltetraprole is considered as a novel fungicidal agent for controlling diseases affecting cereal crops and overcoming pathogen resistance to existing fungicides. © 2018 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Metyltetraprole, a novel putative complex III inhibitor, targets known QoI‐resistant strains of Zymoseptoria tritici and Pyrenophora teres

Suemoto

Matsuzaki

Iwahashi

2019

Pest Management Science

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“…There are fewer than 10 companies in the world that have the capacity to discover, develop, and register herbicides (Jeschke 2016). In contrast, there are many more companies with expertise in robotics that can build automatic weed removal equipment, and development of robotic weeders is much less expensive than development of herbicides.…”

Section: Beginning Of the Robotic Weeding Eramentioning

confidence: 99%

Weed Management in 2050: Perspectives on the Future of Weed Science

et al. 2018

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The discipline of weed science is at a critical juncture. Decades of efficient chemical weed control have led to a rise in the number of herbicide-resistant weed populations, with few new herbicides with unique modes of action to counter this trend and often no economical alternatives to herbicides in large-acreage crops. At the same time, the world population is swelling, necessitating increased food production to feed an anticipated 9 billion people by the year 2050. Here, we consider these challenges along with emerging trends in technology and innovation that offer hope of providing sustainable weed management into the future. The emergence of natural product leads in discovery of new herbicides and biopesticides suggests that new modes of action can be discovered, while genetic engineering provides additional options for manipulating herbicide selectivity and creating entirely novel approaches to weed management. Advances in understanding plant pathogen interactions will contribute to developing new biological control agents, and insights into plant-plant interactions suggest that crops can be improved by manipulating their response to competition. Revolutions in computing power and automation have led to a nascent industry built on using machine vision and global positioning system information to distinguish weeds from crops and deliver precision weed control. These technologies open multiple possibilities for efficient weed management, whether through chemical or mechanical mechanisms. Information is also needed by growers to make good decisions, and will be delivered with unprecedented efficiency and specificity, potentially revolutionizing aspects of extension work. We consider that meeting the weed management needs of agriculture by 2050 and beyond is a challenge that requires commitment by funding agencies, researchers, and students to translate new technologies into durable weed management solutions. Integrating old and new weed management technologies into more diverse weed management systems based on a better understanding of weed biology and ecology can provide integrated weed management and resistance management strategies that will be more sustainable than the technologies that are now failing.

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“…Modern agrochemical discovery faces significant challenges in a rapidly evolving market. These challenges include agrochemical resistance and its management, pest shifts, changes in public perception of agricultural technology, the rising cost of research and development, and evolving regulatory requirements . Agrochemical companies are thus required to constantly devote considerable resources to the crop protection pipeline, and to be innovative and efficient in the process of discovering novel active ingredients (AIs).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical property guidelines for modern agrochemicals

Yu¹,

Lorsbach²,

Castetter³

et al. 2018

Pest Management Science

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The relentless need for the discovery and development of new agrochemicals continues as a result of driving forces such as loss of existing products through the development of resistance, the necessity for products with more favorable environmental and toxicological profiles, shifting pest spectra, and the changing agricultural needs and practices of the farming community. These new challenges underscore the demand for novel, high-quality starting points to accelerate the discovery of new agrochemicals that address market challenges. This article discusses the efforts to identify the optimum ranges of physicochemical properties of agrochemicals through analysis of modern commercial products. Specifically, we reviewed literature studies examining physicochemical property effects and analyzed the properties typical of successful fungicides, herbicides, and insecticides (chewing and sap-feeding pests). From the analysis, a new set of physicochemical property guidelines for each discipline, as well as building block class, are proposed. These new guidelines should significantly aid in the discovery of next-generation agrochemicals. © 2018 Society of Chemical Industry.

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Progress of modern agricultural chemistry and future prospects

Cited by 187 publications

References 80 publications

Metyltetraprole, a novel putative complex III inhibitor, targets known QoI‐resistant strains of Zymoseptoria tritici and Pyrenophora teres

Metyltetraprole, a novel putative complex III inhibitor, targets known QoI‐resistant strains of Zymoseptoria tritici and Pyrenophora teres

Weed Management in 2050: Perspectives on the Future of Weed Science

Physicochemical property guidelines for modern agrochemicals

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