Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma

Qin, Niu; Sun, Qiannan; Bai, Rushui; Zhang, Yunfan; Zhuang, Zimeng; Zhang, Xin; Xin, Tianyi; Chen, Si; Han, Bing

doi:10.3390/ijms231810428

Cited by 17 publications

(6 citation statements)

References 140 publications

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“…OSCC is a common malignant tumor originating from the squamous epithelial tissue of the oral mucosa. [12] The harmful effects of OSCC are primarily manifested in the destruction of oral structures and functions, invasion, and metastasis to the lymphatic system and other organs, leading to a decreased survival rate, especially when metastasis occurs in the cervical lymph nodes. [13,14] In-depth exploration of the molecular mechanisms of OSCC is crucial for targeted drug research.…”

Section: Discussionmentioning

confidence: 99%

CDK1 and CCNA2 play important roles in oral squamous cell carcinoma

Zhang,

Di,

Zhang

et al. 2024

Medicine

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Oral squamous cell carcinoma (OSCC) is a malignant tumor that occurs in oral cavity and is dominated by squamous cells. The relationship between CDK1, CCNA2, and OSCC is still unclear. The OSCC datasets GSE74530 and GSE85195 configuration files were downloaded from the Gene Expression Omnibus (GEO) database and were derived from platforms GPL570 and GPL6480. Differentially expressed genes (DEGs) were screened. The weighted gene co-expression network analysis, functional enrichment analysis, gene set enrichment analysis, construction and analysis of protein–protein interaction (PPI) network, Comparative Toxicogenomics Database analysis were performed. Gene expression heatmap was drawn. TargetScan was used to screen miRNAs that regulate central DEGs. A total of 1756 DEGs were identified. According to Gene Ontology (GO) analysis, they were predominantly enriched in processes related to organic acid catabolic metabolism, centromeric, and chromosomal region condensation, and oxidoreductase activity. In Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, the DEGs were mainly concentrated in metabolic pathways, P53 signaling pathway, and PPAR signaling pathway. Weighted gene co-expression network analysis was performed with a soft-thresholding power set at 9, leading to the identification of 6 core genes (BUB1B, CCNB1, KIF20A, CCNA2, CDCA8, CDK1). The gene expression heatmap revealed that core genes (CDK1, CCNA2) were highly expressed in OSCC samples. Comparative Toxicogenomics Database analysis demonstrated associations between the 6 genes (BUB1B, CCNB1, KIF20A, CCNA2, CDCA8, CDK1) and oral tumors, precancerous lesions, inflammation, immune system disorders, and tongue tumors. The associated miRNAs for CDK1 gene were hsa-miR-203a-3p.2, while for CCNA2 gene, they were hsa-miR-6766-3p, hsa-miR-4782-3p, and hsa-miR-219a-5p. CDK1 and CCNA2 are highly expressed in OSCC. The higher the expression of CDK1 and CCNA2, the worse the prognosis.

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Section: Discussionmentioning

confidence: 99%

CDK1 and CCNA2 play important roles in oral squamous cell carcinoma

Zhang,

Di,

Zhang

et al. 2024

Medicine

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“…Though these nanomaterials have excellent therapeutic efficacies in most cases, the complication lies in their non-biodegradability and cytotoxicity, which limits their application in clinical translation and therapeutics 21 . Organic nanomaterials have better bio-compatibility than inorganic nanomaterials 22 . To attain a greater photothermal effect with biocompatibility, biodegradability, low cytotoxicity, and early removal from the body, different bio-nanomaterials are synthesized, which are discussed in the following section also listed in Table 1 .…”

Section: Bio-nanomaterials Used For Pttmentioning

confidence: 99%

Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer

Beniwal,

Verma,

Putta

et al. 2024

Nanotheranostics

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In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally. Photothermal therapy (PTT) is one of the novel ways to treat and abolish cancer. PTT significantly impacts cancer theranostics compared to other therapies like surgery, chemotherapy, and radiotherapy due to its remarkable binding capability to tumor sites and lower invasiveness into normal healthy tissues. PTT relies on photothermal agents (PTAs), which generate heat by absorbing the near-infrared (NIR) light and destroying cancer cells. Several PTT agents remain longer in the reticuloendothelial system (RES) and induce toxicity, restricting their use in the biomedical field. To overcome this problem, the usage of biodegradable nano-photothermal agents is required. This review has discussed the PTT mechanism of action and different types of novel bio-nanomaterials used for PTT. We also focussed on the combinatorial effects of PTT with other cancer therapies and their effect on human health. The role of LED lights and mild hypothermia in PTT has been discussed briefly in this review.

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“…Although various treatment modalities have been developed for OSCC, such as surgery, chemotherapy, and immunotherapy, their effectiveness in improving patient survival has been limited [4]. Furthermore, these treatments often come with significant side effects, further complicating OSCC patient management [5]. Hence, there is a pressing need for novel therapeutic approaches that can address the limitations of the existing treatment regimens.…”

Section: Introductionmentioning

confidence: 99%

THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC

Wen,

Zhang,

Wang

et al. 2023

IJMS

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Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a crucial role in the initiation, progression, and diverse biological behaviors of OSCC, facilitated by mechanisms such as providing structural support, promoting cell migration and invasion, regulating cell morphology, and modulating signal transduction. This study investigated the involvement of ECM-related genes, particularly THBS1, in the prognosis and cellular behavior of OSCC. The analysis of ECM-related gene data from OSCC samples identified 165 differentially expressed genes forming two clusters with distinct prognostic outcomes. Seventeen ECM-related genes showed a significant correlation with survival. Experimental methods were employed to demonstrate the impact of THBS1 on proliferation, migration, invasion, and ECM degradation in OSCC cells. A risk-prediction model utilizing four differentially prognostic genes demonstrated significant predictive value in overall survival. THBS1 exhibited enrichment of the PI3K/AKT pathway, indicating its potential role in modulating OSCC. In conclusion, this study observed and verified that ECM-related genes, particularly THBS1, have the potential to influence the prognosis, biological behavior, and immunotherapy of OSCC. These findings hold significant implications for enhancing survival outcomes and providing guidance for precise treatment of OSCC.

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Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma

Cited by 17 publications

References 140 publications

CDK1 and CCNA2 play important roles in oral squamous cell carcinoma

CDK1 and CCNA2 play important roles in oral squamous cell carcinoma

Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer

THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC

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