Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix

Jia, Jinhao; Chen, Jianfei; Wang, Guoli; Li, Minjing; Zheng, Qiusheng; Li, Defang

doi:10.1016/j.biopha.2023.115809

Cited by 20 publications

(5 citation statements)

References 176 publications

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“…To identify the ingredients that meet these requirements, we explored the medicinal herbs used in traditional Chinese medicine. Several herbs have been reported to have beneficial effects on amnesia, including Rehmanniae radix [ 31 ], Polygalae radix [ 32 ], Zizyphi spinosi semen [ 33 ], and ATR/AGR [ 10 , 11 , 12 ]. When considering these herbs as foodstuffs, we need to be especially careful about their safety because they will be consumed for a long period.…”

Section: Discussionmentioning

confidence: 99%

New Value of Acorus tatarinowii/gramineus Leaves as a Dietary Source for Dementia Prevention

Umeda,

Sakai,

Shigemori

et al. 2024

Nutrients

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The rhizomes of Acorus tatarinowii Schott and Acorus gramineus Solander are widely used for treating amnesia in traditional Chinese medicine. In contrast, their leaves are usually discarded without their medicinal properties being known. Here, we found that the hot water extract of leaves improved cognition and tau pathology in model mice of frontotemporal dementia, similar to or even better than that of rhizomes. To explore the optimal method of processing, we made three preparations from dried leaves: hot water extract, extraction residue, and non-extracted simple crush powder. Among them, the simple crush powder had the strongest effect on tauopathy in mice. The crush powder also ameliorated Aβ and α-synuclein pathologies and restored cognition in mouse models of Alzheimer’s disease and dementia with Lewy bodies. These findings suggest the potential of Acorus tatarinowii/gramineus leaves as a dietary source for dementia prevention and reveal that simple crushing is a better way to maximize their efficacy.

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Section: Discussionmentioning

confidence: 99%

New Value of Acorus tatarinowii/gramineus Leaves as a Dietary Source for Dementia Prevention

Umeda,

Sakai,

Shigemori

et al. 2024

Nutrients

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“…Catalpol and NAC can clear ROS and reduce cell damage caused by ROS. [25][26][27] Catalpol and NAC can protect cells from apoptosis but cannot promote cell viability after treatment. In the previous CCK8 experiment, it was only found that catalpol or NAC-treated cells had no effect on cell viability, while hydrogen-peroxide-treated cells generated ROS and apoptosis, so the cell survival rate was lower than that of the standard control group after 24 hours and 72 hours.…”

Section: Discussionmentioning

confidence: 99%

The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway

Lang,

Xu,

et al. 2024

DDDT

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“…According to modern research and clinical studies, RRP and its active components are of great neuroprotective effects and have been widely used in Parkinson’s disease (PD), Alzheimer’s disease (AD), stroke by alleviating energy metabolism failure and preventing neuronal apoptosis. These characteristics are related to the pathogenesis of ADHD ( Jia et al, 2023 ). According to a data mining report Radix Rehmanniae Preparata (RRP) was the most commonly used herbal medicine for ADHD ( Ni et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Rehmanniae Radix Preparata ameliorates behavioral deficits and hippocampal neurodevelopmental abnormalities in ADHD rat model

Sun,

Yuan,

Wang

et al. 2024

Front. Neurosci.

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ObjectivesAbnormal hippocampal neurodevelopment, particularly in the dentate gyrus region, may be a key mechanism of attention-deficit/hyperactivity disorder (ADHD). In this study, we investigate the effect of the most commonly used Chinese herb for the treatment of ADHD, Rehmanniae Radix Preparata (RRP), on behavior and hippocampal neurodevelopment in spontaneously hypertensive rats (SHR).MethodsBehavior tests, including Morris water maze (MWM) test, open field test (OFT) and elevated plus maze (EPM) test were performed to assess the effect of RRP on hyperactive and impulsive behavior. Hippocampal neurodevelopment was characterized by transmission electron microscopy, immunofluorescence, Golgi staining and Nissl staining approaches. Regulatory proteins such as Trkb, CDK5, FGF2/FGFR1 were examined by Western blot analysis.ResultsThe results showed that RRP could effectively control the impulsive and spontaneous behavior and improve the spatial learning and memory ability. RRP significantly reduced neuronal loss and increased the number of hippocampal stem cells, and promoted synaptic plasticity. In addition, FGF/FGFR signaling was upregulated after RRP treatment.ConclusionRRP can effectively reduce impulsive and spontaneous behavior and ameliorate hippocampal neurodevelopmental abnormalities in ADHD rat model.

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Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix

Cited by 20 publications

References 176 publications

New Value of Acorus tatarinowii/gramineus Leaves as a Dietary Source for Dementia Prevention

New Value of Acorus tatarinowii/gramineus Leaves as a Dietary Source for Dementia Prevention

The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway

Rehmanniae Radix Preparata ameliorates behavioral deficits and hippocampal neurodevelopmental abnormalities in ADHD rat model

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