Progress of research on Inonotus obliquus

Zhong, Xiaoyong; Ren, Kuang; Lü, Shijie; Shuyan, Yang; Dongzhi, Sun

doi:10.1007/s11655-009-0156-2

Cited by 44 publications

(22 citation statements)

References 20 publications

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“…It is parasitic on mature birch and mainly distributed in the countries located at 45°N-50°N latitudes (Russia, Finland, China, Japan, and so on) (Hu et al, 2009). Chaga mushroom has bioactive compounds such as β-glucans, triterpenoids, phenolic compounds, lignins, and melanin complexes to protect itself from environmental stresses such as cold, invasion of pathogen, and competition for nutrients with other microbial species (Zhong et al, 2009;Zheng et al, 2011). These bioactive compounds have been known to have antioxidant, anti-inflammatory, anti-cancer, hypoglycemic, anti-virus, and other functional activities (Zhong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Chaga mushroom has bioactive compounds such as β-glucans, triterpenoids, phenolic compounds, lignins, and melanin complexes to protect itself from environmental stresses such as cold, invasion of pathogen, and competition for nutrients with other microbial species (Zhong et al, 2009;Zheng et al, 2011). These bioactive compounds have been known to have antioxidant, anti-inflammatory, anti-cancer, hypoglycemic, anti-virus, and other functional activities (Zhong et al, 2009). Especially, phenolic compounds in chaga mushroom are known to have strong antioxidant activities related to therapeutic effects against diseases associated with oxidative stress such as cardiovascular diseases, diabetes, and cancer (Seo & Lee, 2010;Khatua et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction

Hwang

Yang

Kim

et al. 2019

LWT

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Chaga mushroom (Inonotus obliquus) has been known to have antioxidant, anti-virus, anti-inflammatory, and anti-tumor effects due to its bioactive compounds such as β-glucans, triterpenoids, phenolic compounds, and melanin complexes. This mushroom has been used as a folk remedy since the 16th century and mainly consumed as extracted. Hot water extraction, which is a traditional method preparing chaga mushroom extract, has limitations requiring a large amount of solvent and long extraction time, resulting in degradation and coagulation of bioactive compounds. The objective of this study was to develop efficient methods extracting bioactive compounds in chaga mushroom, compared with hot water extraction. High II temperature and pressure, enzyme, and ultrasound extractions were used as non-traditional extraction methods. Chaga mushroom extracts were prepared under conditions determined by preliminary experiments. β-Glucans were higher in high temperature and pressure and enzyme extracts than in hot water extract. Total triterpenoids were higher in the enzyme and ultrasound extracts than in the hot water extract. Total phenolic compounds were higher in the high temperature and pressure extract than in the hot water extract. Major phenolic compounds in the chaga mushroom extracts, which were identified by HPLC, LC-MS, and GC-MS, were 3,4-dihydroxybenzaldehyde and coniferyl aldehyde, which were the highest in the high temperature and pressure and enzyme extracts, respectively. Antioxidant activities were the highest in the high temperature and pressure extract which had the highest content of phenolic compounds. In conclusion, high temperature and pressure and enzyme extractions may be efficient methods to produce chaga mushroom extracts with a large amount of bioactive compounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction

Hwang

Yang

Kim

et al. 2019

LWT

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“…Especially, Inonotus obliquus (I. obliquus), a traditional medicinal mushroom, has been widely used to promote health and longevity. I. obliquus is known as cinder conk and belongs to the Hymenochaetaceae family (Zhong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus

Won

Lee

Kwon

et al. 2011

Molecules and Cells

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In this study, we investigated the immunostimulating activity of polysaccharides isolated from fruiting body of Inonotus obliquus (PFIO). Additionally, the signaling pathway of PFIO-mediated macrophage activation was investigated in RAW264.7 macrophage cells. We found that PFIO was capable of promoting NO/ROS production, TNF-α secretion and phagocytic uptake in macrophages, as well as cell proliferation, comitogenic effect and IFN-γ/IL-4 secretion in mouse splenocytes. PFIO was able to induce the phosphorylation of three MAPKs as well as the nuclear translocation of NF-κB, resulting in activation of RAW264.7 macrophages. PFIO also induced the inhibition of TNF-α secretion by anti-TLR2 mAb, consequently, PFIO might be involved in TNF-α secretion via the TLR2 receptor. In addition, our results showed that oral administration of PFIO suppressed in vivo growth of melanoma tumor in tumorbearing mice. In conclusion, our experiments presented that PFIO effectively promotes macrophage activation through the MAPK and NF-κB signaling pathways, suggesting that PFIO may potentially regulate the immune response.

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“…Plant and fungi extracts that have been shown to help with alcohol degradation and toxicity include Viscum album L., Inonotus obliquus and Acanthopanax senticosus H. [139]. The main compounds extracted from these formulations that could be responsible for the protective actions are viscotoxins, flavonoids, triterpene acids, mistletoe lectins, melanins (lanoline alkane triterpenes), polyphenols, lignans, and coumarins, syringic acid, chlorogenic acid, eleutheroside, syringaresinol-di-glucoside, and isofraxidin [140][141][142][143]. The same composition in combination with Lycium chinense L., has also shown alcohol degradation, protection of the gastric mucous membrane, and reduction in nitric oxide and tumor necrosis factor production [139].…”

Section: Complex Formulationsmentioning

confidence: 99%

Preventing and Mitigating Alcohol Toxicity: A Review on Protective Substances

2018

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This review covers three fundamental aspects of alcohol consumption and research efforts around the prevention and mitigation of its toxic effects in the human body. First, the sociocultural aspects of alcohol consumption are analysed, including drinking habits and strategies to combat intoxication. Second, we briefly introduce the biochemical aspects of ethanol metabolism and the biochemical pathways leading to its degradation, particularly the activation of toxic response pathways. Finally, we review current evidence and research efforts for finding compounds and substances able to prevent and mitigate the toxic effects of alcohol when over-indulgence has occurred. The toxic effects appear as a time-evolution process based on the stage of intoxication. We explore different compounds and formulations traditionally used to combat alcohol toxicity, as well as state-of-the-art research in the topic for novel molecules and formulations. Although we aimed to categorise which compounds are more effective for a particular level of alcohol intoxication, it is impossible to fully prevent or mitigate toxicity effects by only the compounds in isolation, further research is required to establish the long-term prevention and mitigation from the clinical point of view.

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Progress of research on Inonotus obliquus

Cited by 44 publications

References 20 publications

Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction

Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction

Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus

Preventing and Mitigating Alcohol Toxicity: A Review on Protective Substances

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