Progress on diagnosis and treatment of central nervous system tuberculosis

Chen, Wei; Huang, Lili; Tang, Qiusha; Wang, Shiwei; Hu, Chunmei; Zhang, Xia

doi:10.1016/j.jrid.2020.07.005

Cited by 17 publications

(9 citation statements)

References 81 publications

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“…Medical therapy is currently the recommended treatment for disseminated tuberculosis. The regimen of isoniazid, rifampicin, ethambutol, and pyrazinamide along with steroids usually results in clinical cure of CNS‐TB 15 . The child in our case also responded well to the medical treatment, gained his lower limb power, and was able to walk at 1 month follow‐up.…”

Section: Discussionmentioning

confidence: 58%

Stroke in a child with pulmonary tuberculosis and pleural effusion—An important clue for the diagnosis of disseminated central nervous system tuberculosis

Chaudhary

Gupta

Poudel

et al. 2023

Clinical Case Reports

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Section: Discussionmentioning

confidence: 58%

Stroke in a child with pulmonary tuberculosis and pleural effusion—An important clue for the diagnosis of disseminated central nervous system tuberculosis

Chaudhary

Gupta

Poudel

et al. 2023

Clinical Case Reports

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“…This patient was treated according to the British Infection Society guidelines, which state that the initial treatment regimen for CNS-TB is a combination of isoniazid, rifampicin and pyrazinamide plus ethambutol (or streptomycin or fluoroquinolone) for 2 -3 months, followed by isoniazid and rifampicin for up to 12 months of consolidation therapy. If necessary, the total duration of treatment can be extended to 18 months [17]. The use of glucocorticoids such as dexamethasone has been described to inhibit inflammation, reduce cerebral oedema [18].…”

Section: Discussionmentioning

confidence: 99%

Intraventricular Hemorrhage, a Rare Complication of a Cerebral Tuberculoma: Study of a Case in the Neurology Department of the University Hospital of Conakry

Idrissa¹,

Lamine²,

Négué³

et al. 2023

CRCM

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Intraventricular haemorrhage (IVH) is an extremely rare and poorly described complication of central nervous system Tuberculosis (CNS-TB). In this study, we report the case of a 42-year-old man who presented with a weakness of the left hemibody with diffuse headache, altered consciousness associated with fever. No notion of contagion was noted. Brain computed tomography (CT) showed a hematoma in the occipital horns of the lateral ventricles with peri-lesional oedema of the right hemisphere; after injection of contrast product (CP), there were ring-shaped contrasts in the occipital horn of the lateral ventricle and the right thalamus. Angioscan showed no aneurysms or vascular anomalies. Chest X-ray showed micronodular opacities less than 1.5 cm in size in relation to miliary. Xpert MTB/RIF of sputum and cerebrospinal fluid (CSF) showed Mycobacterium tuberculosis (MT). The patient's course was favourable under antihypertensive and antitubercular treatment. Conclusion: This case illustrates the diagnostic difficulties of CNS-TB due to the polymorphism of the clinical and radiological presentation of CNS-TB.

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“…Indeed, diverse experimental observations proved that polymeric NPs increase BBB drug(s) permeation and promote the eradication of bacterial‐induced meningitis 132,133 . Regarding CNS‐TB treatment, because antitubercular drugs show limited ability to cross the BBB, diverse polymeric NPs have been generated to improve their delivery to the CNS and resolve the infection 134 . Among them, it is worth mentioning a PLG NP system in which three to four anti‐mycobacterial drugs (i.e., isoniazid, rifampicin, pyrazinamide, and ethambutol) can be encapsulated.…”

Section: The Journey Of Nps Within the Bodymentioning

confidence: 99%

Nanoparticle delivery through the BBB in central nervous system tuberculosis

Griego

Scarpa

Matteis

et al. 2023

Ibrain

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Recent advances in Nanotechnology have revolutionized the production of materials for biomedical applications. Nowadays, there is a plethora of nanomaterials with potential for use towards improvement of human health.On the other hand, very little is known about how these materials interact with biological systems, especially at the nanoscale level, mainly because of the lack of specific methods to probe these interactions. In this review, we will analytically describe the journey of nanoparticles (NPs) through the brain, starting from the very first moment upon injection. We will preliminarily provide a brief overlook of the physicochemical properties of NPs. Then, we will discuss how these NPs interact with the body compartments and biological barriers, before reaching the blood-brain barrier (BBB), the last gate guarding the brain. Particular attention will be paid to the interaction with the biomolecular, the bio-mesoscopic, the (blood) cellular, and the tissue barriers, with a focus on the BBB. This will be framed in the context of brain infections, especially considering central nervous system tuberculosis (CNS-TB), which is one of the most devastating forms of human mycobacterial infections. The final aim of this review is not a collection, nor a list, of current literature data, as it provides the readers with the analytical tools and guidelines for the design of effective and rational NPs for delivery in the infected brain.

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Progress on diagnosis and treatment of central nervous system tuberculosis

Cited by 17 publications

References 81 publications

Stroke in a child with pulmonary tuberculosis and pleural effusion—An important clue for the diagnosis of disseminated central nervous system tuberculosis

Stroke in a child with pulmonary tuberculosis and pleural effusion—An important clue for the diagnosis of disseminated central nervous system tuberculosis

Intraventricular Hemorrhage, a Rare Complication of a Cerebral Tuberculoma: Study of a Case in the Neurology Department of the University Hospital of Conakry

Nanoparticle delivery through the BBB in central nervous system tuberculosis

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