Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery

Cheng, Xian; Yuan, Qijuan; Bao, Ziting; Liu, Guiting; Wu, Jun

doi:10.1016/j.cclet.2019.03.052

Cited by 55 publications

(10 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In spite of the promising potential of intelligent hydrogels in biomedical fields, they were made using traditional procedures and still face a number of major obstacles, such as uncontrolled stimulus-response and low responsive sensitivity. Recently, it was demonstrated that reversible addition-fragmentation chain transfer (RAFT) polymerization is an adaptable approach for fabricating intelligent hydrogels with improved stimulus-response features, attributed to its ability to effectively build hydrogel precursors with well-defined structures, including block copolymer, graft copolymer, and star copolymer (Xian et al., 2020 ).…”

Section: Current Hydrogel-based Strategies For the Bone Tumors Therapymentioning

confidence: 99%

Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations

Shao

Wang

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

Primary bone tumors especially, sarcomas affect adolescents the most because it originates from osteoblasts cells responsible for bone growth. Chemotherapy, surgery, and radiation therapy are the most often used clinical treatments. Regrettably, surgical resection frequently fails to entirely eradicate the tumor, which is the primary cause of metastasis and postoperative recurrence, leading to a high death rate. Additionally, bone tumors frequently penetrate significant regions of bone, rendering them incapable of self-repair, and impairing patients' quality of life. As a result, treating bone tumors and regenerating bone in the clinic is difficult. In recent decades, numerous sorts of alternative therapy approaches have been investigated due to a lack of approved treatments. Among the novel therapeutic approaches, hydrogel-based anticancer therapy has cleared the way for the development of new targeted techniques for treating bone cancer and bone regeneration. They include strategies such as co-delivery of several drug payloads, enhancing their biodistribution and transport capabilities, normalizing accumulation, and optimizing drug release profiles to decrease the limitations of current therapy. This review discusses current advances in functionalized hydrogels to develop a new technique for treating bone tumors by reducing postoperative tumor recurrence and promoting tissue repair.

show abstract

Section: Current Hydrogel-based Strategies For the Bone Tumors Therapymentioning

confidence: 99%

Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations

Shao

Wang

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…Based on the fact that chitosan (CS)-based materials are promising carriers for drug delivery 48,49 , especially due to the improvement in water solubility, Ilaria Cacciotti et al 50 51 was used to deliver lipid-coated CDDP nanoparticles (LCC-NPs) via the transdermal route to treat oral squamous cancer, and the apoptotic index (58.6%) of cancer cells, as well as the low systemic toxicity (including nephrotoxicity, pulmonary toxicity, and hepatotoxicity), confirmed the efficiency and safety of this anticancer treatment. In addition, as three-dimensional water-rich materials, hydrogels have an excellent drug loading capacity and biocompatibility and are ideal tools for improving anticancer drug control and release kinetics [52][53][54] . A self-assembling peptide hydrogel (ac-(RADA) 4 -CONH 2 ) 55 designed by Christina Karavasili et al was applied for codelivering curcumin and DOX to treat head and neck cancers.…”

Section: Biomaterial-mediated Chemotherapymentioning

confidence: 99%

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

et al. 2021

View full text Add to dashboard Cite

Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients’ lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

show abstract

“…In the past thirty years, supramolecular chemistry has become even more sophisticated and quickly developed due to its applications in a variety of disciplines and fields [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. As a typical supramolecular material, low-molecular-weight gels (LMWGs) are a kind of soft material between a solid and liquid which have been developed rapidly and widely used in electrolyte materials [ 12 ], sensors [ 13 , 14 ], drug delivery systems [ 15 ], liquid crystal [ 16 ], supramolecular chirality [ 17 , 18 , 19 ], light-harvesting systems [ 20 , 21 ], surfactants [ 22 ] and other fields [ 23 , 24 , 25 , 26 , 27 , 28 ]. Organic molecules can be self-assembled into organogel or hydrogel under the driving force of noncovalent interactions, such as a hydrogen bond, metal coordination, π–π stacking, hydrophobic effect, electrostatic force and van der Waals force [ 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Bis-Pyridine-Based Organogel with AIE Effect and Sensing Performance towards Hg2+

Gao

Qin

Wang

et al. 2022

Gels

View full text Add to dashboard Cite

A novel gelator (1) based on a bis-pyridine derivative was designed and synthesized, which could form stable gels in methanol, ethanol, acetonitrile, ethyl acetate, DMF/H2O (4/1, v/v) and DMSO/H2O (4/1, v/v). The self-assembly process of gelator 1 was studied by field emission scanning electron microscopy (FESEM), UV–vis absorption spectroscopy, fluorescence emission spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction and a water contact angle experiment. Gelator 1 exhibited obvious AIE behavior. On the base of its AIE, the gel of 1 could detect Hg2+, which resulted in fluorescence quenching and a gel–sol transition. 1H NMR titration experiments with Hg2+ revealed that the metal coordination interaction induced the fluorescence quenching and the breakdown of the noncovalent interaction in the gel system. This research provides a new molecular mode for designing a functional self-assembly gel system.

show abstract

Progress on intelligent hydrogels based on RAFT polymerization: Design strategy, fabrication and the applications for controlled drug delivery

Cited by 55 publications

References 142 publications

Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations

Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

Bis-Pyridine-Based Organogel with AIE Effect and Sensing Performance towards Hg2+

Contact Info

Product

Resources

About