Progress on Medical Implant: A Review and Prospects

Pandey, Ankur; Sahoo, Swagatadeb

doi:10.1007/s42235-022-00284-z

Cited by 18 publications

(4 citation statements)

References 243 publications

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“…[ 9,10 ] Ti6Al4V, in particular, is widely used in biomedicine such as orthopedic screws, spinal fusion cages, total hip replacement, or total knee replacement prostheses due to its exceptional mechanical properties and biocompatibility as well as excellent corrosion resistance. [ 11–13 ]…”

Section: Introductionmentioning

confidence: 99%

Novel‐Ink‐Based Direct Ink Writing of Ti6Al4V Scaffolds with Sub‐300 µm Structural Pores for Superior Cell Proliferation and Differentiation

Xu,

Chen

et al. 2024

Adv Healthcare Materials

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Ti6Al4V scaffolds with pore sizes between 300 and 600 μm are deemed suitable for bone tissue engineering. However, a significant proportion of pores in human bones are smaller than 300 μm, playing a crucial role in cell proliferation, differentiation, and bone regeneration. Ti6Al4V scaffolds with these small‐sized pores have not been successfully fabricated, and their cytocompatibility remains unknown. The paper presents a novel ink formula specifically tailored for the fabrication of Ti6Al4V scaffolds featuring precise and unobstructed sub‐300 μm structural pores, achieved by investigating the rheological properties and printability of five inks containing 60–77.5 vol.% Ti6Al4V powders and PS/DCM/NMP binders. Ti6Al4V scaffolds with 50 μm to 600 μm pores are fabricated via direct ink writing and subsequently subjected to in vitro MC3T3‐E1 and BMSCs experiments. The live/dead assay, FITC‐ phalloidin/DAPI staining, and CCK‐8 assay indicate that the 100 μm pore‐sized scaffolds exhibit the highest cell adhesion and proliferation capacity. The alizarin red staining, RT‐qPCR assay, and immunocytochemical staining demonstrate the superior osteogenic differentiation potential of 100 μm and 200 μm pore‐sized scaffolds. The study highlights the importance of sub‐300 μm structural pores and redefines the optimal pore size for Ti6Al4V scaffolds, advancing the development of bone tissue engineering and clinical medicine.This article is protected by copyright. All rights reserved

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Section: Introductionmentioning

confidence: 99%

Novel‐Ink‐Based Direct Ink Writing of Ti6Al4V Scaffolds with Sub‐300 µm Structural Pores for Superior Cell Proliferation and Differentiation

Xu,

Chen

et al. 2024

Adv Healthcare Materials

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“…Due to their outstanding mechanical characteristics and their ability to resist corrosion, titanium and its alloys find widespread use in various fields, including orthopedics, dentistry, and the development of stents [1,2]. Titanium and its alloys are regarded as the favored option for replacing or repairing damaged hard tissues due to their biocompatibility, impressive strength-todensity ratio, and remarkable corrosion resistance, facilitated by the formation of a protective layer of oxide on their surface [3,4]. Nonetheless, the failure of Ti implants can be attributed to bacterial adhesion and the formation of biofilms on their surfaces because they are foreign objects within the body [5,6].…”

Section: Introductionmentioning

confidence: 99%

Impact of zinc oxide on dielectric properties of forsterite coated titanium based medical implants

Pandey,

Sahoo

2024

Phys. Scr.

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Zinc oxide-doped forsterite solutions are synthesized through the sol-gel approach by varying the weight percentage of zinc oxide. These solutions are then applied to titanium (Ti) substrates to form zinc oxide-doped forsterite coated Ti substrate samples using the dip-coating method. The structural and surface morphology analyses of the samples are conducted using X-ray Diffraction (XRD) and Scanning Electron Microscope (SEM). Dielectric properties, encompassing dielectric constant, dielectric loss, alternating current conductivity, loss tangent, and relaxation time are explored at room temperature over a frequency range of 200 MHz to 20 GHz utilizing a Vector Network Analyzer (VNA) setup. The impact of zinc oxide on the structure, morphology, and dielectric properties of the samples, particularly in medical implant applications, is extensively discussed. The results indicate that samples with a higher weight percentage of zinc oxide demonstrate superior dielectric characteristics.

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“…Because systemic dosages may not be effective in overcoming the constraints of traditional therapy, the local injection of medications to the bone is also acknowledged as a possible alternative [15]. Therefore, surface modification for titanium is frequently necessary to enhance its bio-performance as an implant [11,12,[16][17][18]. Choosing biomimetic dental implants with antibacterial properties (in such a way to prevent multidrug resistance) in those with a history of periodontitis may help avoid peri-implantitis, avoiding recurring visits to the doctor for debridement and significantly decreasing expenses and patient suffering [14].…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin/ZnO Coated TiO2 Nanotubes for Improved Antimicrobial Effect of Ti Dental Implants

Păun,

Dumitriu,

Ungureanu

et al. 2023

Materials

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The aim of the present research is to develop a novel hybrid coating for a Ti dental implant that combines nature-inspired biomimetic polymers and TiO2 nanostructures with an entrapped ZnO antimicrobial agent. ZnO was used in other studies to cover the surface of Ti or Ti–Zr to reduce the need of clinical antibiotics, prevent the onset of peri-implantitis, and increase the success rate of oral clinical implantation. We developed an original coating that represents a promising approach in clinical dentistry. The titanium surface was first anodized to obtain TiO2 nanotubes (NT). Subsequently, on the NT surface, silk fibroin isolated from Bombyx mori cocoons was deposited as nanofibers using the electrospun technique. For an improved antibacterial effect, ZnO nanoparticles were incorporated in this biopolymer using three different methods. The surface properties of the newly created coatings were assessed to establish how they are influenced by the most important features: morphology, wettability, topography. The evaluation of stability by electrochemical methods in simulated physiological solutions was discussed more in detail, considering that it could bring necessary information related to the behavior of the implant material. All samples had improved roughness and hydrophilicity, as well as corrosion stability (with protection efficiency over 80%). The antibacterial test shows that the functional hybrid coating has good antibacterial activity because it can inhibit the proliferation of Staphylococcus aureus up to 53% and Enterococcus faecalis up to 55%. All Ti samples with the modified surface have proven superior properties compared with unmodified TiNT, which proved that they have the potential to be used as implant material in dentistry.

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Progress on Medical Implant: A Review and Prospects

Cited by 18 publications

References 243 publications

Novel‐Ink‐Based Direct Ink Writing of Ti6Al4V Scaffolds with Sub‐300 µm Structural Pores for Superior Cell Proliferation and Differentiation

Novel‐Ink‐Based Direct Ink Writing of Ti6Al4V Scaffolds with Sub‐300 µm Structural Pores for Superior Cell Proliferation and Differentiation

Impact of zinc oxide on dielectric properties of forsterite coated titanium based medical implants

Silk Fibroin/ZnO Coated TiO2 Nanotubes for Improved Antimicrobial Effect of Ti Dental Implants

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