In a number of reported instances, implosions utilizing fuel mixtures have resulted in anomalously low fusion yields below those predicted by radiation-hydrodynamics simulations. Inter-species ion diffusion has been suggested as a possible cause of the observed yield degradation in fuel mixture implosions. An experimental platform utilizing hydro-equivalent deuterium–tritium (DT), deuterium–tritium–hydrogen (DTH), and deuterium-tritium-helium3 (DT3He) capsule implosions was developed to determine whether the inter-species ion diffusion theory may describe the resulting fuel mixture implosion behavior. The implosion experiments were performed at the Omega laser facility. X-ray images and shell areal density diagnostics results show that the hydro-equivalent three capsules (DT, DTH, and DT3He) have similar compression behavior. However, nuclear yield deviation was observed from the scaling determined using a fusion yield formula. In the DT3He mixture, a reduced yield of a factor of 0.65 ± 0.13 was observed, which is similar to a yield reduction observed in D3He mixture by Rygg et al. (i.e., Rygg effect). In contrast, in the DTH mixture, a factor of 1.17 ± 0.15 yield increase was observed, which we named the inverse Rygg effect. The yield increase observed in the DTH mixture is consistent with the inter-species ion diffusion theory where lighter H diffuses away from the core and concentrated DT in the core produces higher yield. An inter-species ion diffusion model, the Zimmerman–Paquette–Kagan–Zhdanov model, implemented in a Lagrangian radiation-hydrodynamics fluid code, was also used to analyze the present data, without the need to assume hydrodynamic equivalence of the capsules, but it does not completely explain the DTH or DT3He capsules although its effects are in the correct direction. Simulation-based Bayesian inference was used in the latter analysis to quantify the uncertainty in the numerical simulations. The simulation-based analysis resulted in an inferred Rygg-effect yield decrease factor of 0.91 ± 0.02 for the DT3He mixture, and an inferred inverse-Rygg yield increase factor of 1.21 ± 0.04 for the DTH mixture, based on simulations ignoring ion diffusion.