Progress on the Chemistry of Dibenzocyclooctadiene Lignans

Abstract

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Ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometric procedure for qualitative and quantitative analyses of nortriterpenoids and lignans in the genus Schisandra

“…The reference standards of six nortriterpenoids, namely micrandilactone A (1), micrandilactone D (2), henridilactone D (3), henridilactone B (4), henridilactone A (5) and lancifodilactone D (6), are all of the schisanartane skeleton type (Fig. 1) and were analyzed by UPLC-QTOF-MS. All reference nortriterpenoids produced abundant [M+H] + ions as the base peak in positive ESI-MS spectra.…”

“…Reports have shown that the ripe fruits of the two plants exhibit similar actions, and have been primarily used as sedative, tonic agents to replenish and promote the production of body fluid, as well as tonify the kidney to relieve mental strain and for the treatment of hepatitis [2]. Although the fruits of these two plants have been accepted as two different crude drugs by the Chinese Pharmacopoeia since 2000 [2], both plants are found to be a rich source of lignans [3][4][5][6][7] and terpenoids [8][9][10][11] in particular the dibenzocylooctadiene lignans exhibiting various biological activities.…”

Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

“…More than 100 Schisandraceae lignans with the scaffold structure of the dibenzocyclooctadiene skeleton have been isolated from the plants of Schisandraceae family [4]. Previous studies demonstrated that certain of the dibenzocyclooctadiene lignans protect neurons from toxicity induced by glutamate, Aß peptide, and hydrogen peroxide [13,9,10], and exhibited protective effects against neuronal cell death in stroke, other neurodegenerative diseases and cognitive impairments in the model of Alzheimer's disease.…”

Dibenzocyclooctadiene lignans from Magnolia and Talauma (Magnoliaceae): Their absolute configuration ascertained by circular dichroism and X-ray crystallography and re-evaluation of previously published pyramidatin structures

“…The concomitant occurrence of these highly complex dibenzocyclooctadiene-type lignans in both sections is, however, a chemosystematically interesting finding. Finally, it is worth to note that in the review on dibenzocyclooctadienes by Chang et al (2005), the pyramidatins first discovered by Song et al (2000) were not mentioned.…”

“…For a more recent review on this compound class see Chang et al (2005). However, there is only one report (Song et al, 2000) on dibenzocyclooctadienes bearing an ether bridge as found in Magnoliaceae.…”