Progress Toward an In Vivo Surface-Enhanced Raman Spectroscopy Glucose Sensor

Lyandres, Olga; Yuen, Jonathan M.; Shah, Nilam C.; VanDuyne, Richard P.; Walsh, Joseph T.; Glucksberg, Matthew R.

doi:10.1089/dia.2007.0288

Cited by 124 publications

(96 citation statements)

References 59 publications

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“…The phenomenon of surface-enhanced Raman scattering (SERS) [1][2][3][4] possesses a great potential in sensing and recognition [5][6][7] of molecular structures up to a single-molecule level. 8,9 In the SERS setup plasmon excitations supported by the noble metal substrate focus the probing laser field below the diffraction limit and also enhance the spontaneous emission from the analyte ABSTRACT The surface-enhanced Raman scattering (SERS) signal from an AgFON plasmonic substrate, recoated with benzenethiol, was observed to increase by about 100% upon heating for 3.5 min at 100º C and 1.5 min at 125º C. The signal intensity was found to increase further by about 80% upon a 10-s exposure to a high-intensity (3.2 kW/cm 2 ) 785-nm cw laser, corresponding to 40 mW in a 40±5-μm diameter spot.…”

Section: Introductionmentioning

confidence: 99%

Increase of SERS Signal upon Heating or Exposure to a High-Intensity Laser Field: Benzenethiol on an AgFON Substrate

2012

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The surface-enhanced Raman scattering (SERS) signal from an AgFON plasmonic substrate, recoated with benzenethiol, was observed to increase by about 100% upon heating for 3.5 min at 100 °C and 1.5 min at 125 °C. The signal intensity was found to increase further by about 80% upon a 10 s exposure to a high-intensity (3.2 kW/cm2) 785 nm CW laser, corresponding to 40 mW in a 40 ± 5 μm diameter spot. The observed increase in the SERS signal may be understood by considering the presence of benzenethiol molecules in an intermediate or “precursor” state in addition to conventionally ordered molecules forming a self-assembled monolayer. The increase in the SERS signal arises from the conversion of the molecules in the precursor state to the chemisorbed state due to thermal and photothermal effects.

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Section: Introductionmentioning

confidence: 99%

Increase of SERS Signal upon Heating or Exposure to a High-Intensity Laser Field: Benzenethiol on an AgFON Substrate

2012

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“…159 The next step involved implanting their substrate inside a living animal and verifying if the platform could provide quantitative accuracy in vivo. 160 Using Sprague-Dawley rats and SESORS, they demonstrated that consistent, stable, and accurate Raman measurements of glucose could be performed when the probe was implanted and surrounded by interstitial fluid (rather than blood). The SESORS approach eliminated the need to remove the platform from the rat and allowed direct detection of glucose with high accuracy.…”

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confidence: 99%

Raman Spectroscopy of Blood and Blood Components

et al. 2017

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Blood is a bodily fluid that is vital for a number of life functions in animals. To a first approximation, blood is a mildly alkaline aqueous fluid (plasma) in which a large number of free-floating red cells (erythrocytes), white cells (leucocytes), and platelets are suspended. The primary function of blood is to transport oxygen from the lungs to all the cells of the body and move carbon dioxide in the return direction after it is produced by the cells' metabolism. Blood also carries nutrients to the cells and brings waste products to the liver and kidneys. Measured levels of oxygen, nutrients, waste, and electrolytes in blood are often used for clinical assessment of human health. Raman spectroscopy is a nondestructive analytical technique that uses the inelastic scattering of light to provide information on chemical composition, and hence has a potential role in this clinical assessment process. Raman spectroscopic probing of blood components and of whole blood has been on-going for more than four decades and has proven useful in applications ranging from the understanding of hemoglobin oxygenation, to the discrimination of cancerous cells from healthy lymphocytes, and the forensic investigation of crime scenes. In this paper, we review the literature in the field, collate the published Raman spectroscopy studies of erythrocytes, leucocytes, platelets, plasma, and whole blood, and attempt to draw general conclusions on the state of the field.

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“…This specific site had a low surface coverage (approximately three per colloidal particle); however, the authors claimed an enhancement of 10 6 . This enhancement was believed to be due to a charge transfer mechanism.…”

Section: Resultsmentioning

confidence: 97%

“…Detection and discrimination of specimens in complex biological media are also a necessity, together with reproducible results, cost and time effectiveness, and ease of use under most conditions. Due to its unique ability to provide ultrasensitive detection limits, SERS has been used to detect molecular modifications involved in disease, such as cancer, 3,5 diabetes, 6 etc.…”

Section: Introductionmentioning

confidence: 99%

Double Amino Functionalized Ag Nanoparticles as SERS Tags in Raman Diagnostic

Pinzaru¹,

Fălămaș²,

Dehelean³

et al. 2013

Croat. Chem. Acta

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Abstract. Surface enhanced Raman scattering (SERS) effect is currently exploited as the basis of a new type of optical labels for in vivo investigation of the tissues, especially for early medical diagnostic. Silver colloidal nanoparticles decorated with chemisorbed cresyl violet molecular species could act as hybrid SERS labels. Their Raman scattering properties have been characterized here using different SERS techniques, and probing different excitation wavelengths, even in the near infrared. Obtaining FT-SERS signal of cresyl violet is of particular importance for applying FT-Raman spectroscopy to the tissues or cells, in providing sensitive information in the close vicinity of the SERS label incubated into the biological sample. Furthermore, upon chemisorption on the silver nanoparticles, cresyl violet molecular orientation provided both amino functional groups free of interaction with the silver, resulting double aminofunctionalized Ag nanoparticles suitable for DNA tagging. SERS tests of melanoma induced in mouse using CV-Ag SERS label suggested the possibility to setup the tissue labeling procedure for skin cancer monitoring.(doi: 10.5562/cca2067)

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Progress Toward an In Vivo Surface-Enhanced Raman Spectroscopy Glucose Sensor

Abstract: We show successful use of the SERS glucose sensor in rats, making it the first in vivo SERS sensor. Furthermore, we demonstrate free space transdermal detection of a SERS signal through the rat's skin as an initial step toward developing a transcutaneous sensor.

Cited by 124 publications

References 59 publications

Increase of SERS Signal upon Heating or Exposure to a High-Intensity Laser Field: Benzenethiol on an AgFON Substrate

Increase of SERS Signal upon Heating or Exposure to a High-Intensity Laser Field: Benzenethiol on an AgFON Substrate

Raman Spectroscopy of Blood and Blood Components

Double Amino Functionalized Ag Nanoparticles as SERS Tags in Raman Diagnostic

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