Progress Toward Hepatitis B Control and Elimination of Mother-to-Child Transmission of Hepatitis B Virus — Western Pacific Region, 2005–2017

Woodring, Joseph; Pastore, Roberta; Brink, Anne; Ishikawa, Naoko; Takashima, Yusuke; Tohme, Rania A.

doi:10.15585/mmwr.mm6808a2

Cited by 50 publications

(55 citation statements)

References 4 publications

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“…By 2010, more than 98% of children were completing the three-dose hepatitis B vaccination series each year [5]. However, an estimated 90 million individuals of whom the majority are older than 30 years of age [6], are HBV surface antigen positive (HBsAg+) and at risk of developing cirrhosis and liver cancer [7,8]. Persons who are HBsAg+ can transmit HBV to susceptible persons.…”

Section: Introductionmentioning

confidence: 99%

Using a hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu provinces to improve data quality and assess program effectiveness, China, 2015

et al. 2020

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Background: Monitoring hepatitis B surveillance data is important for evaluating progress towards global hepatitis B elimination goals. Accurate classification of acute and chronic hepatitis infections is essential for assessing program effectiveness. Methods: We evaluated hepatitis B case-reporting at six hospitals in Fujian, Hainan and Gansu provinces in 2015 to assess the accuracy of case classification. We linked National Notifiable Disease Reporting System (NNDRS) HBV case-reports with hospital information systems and extracted information on age, gender, admission ward and viral hepatitis diagnosis from medical records. To assess accuracy, we compared NNDRS reported case-classifications with the national HBV case definitions. Multivariable logistic regression was used to identify factors associated with misclassification. Results: Of the 1420 HBV cases reported to NNDRS, 23 (6.5%) of the 352 acute reports and 648 (60.7%) of the 1068 chronic reports were correctly classified. Of the remaining, 318 (22.4%) were misclassified and 431 (30.4%) could not be classified due to the lack of supporting information. Based on the multivariable analysis, HBV cases reported from Hainan (aOR = 1.8; 95% CI: 1.3-2.4) and Gansu (aOR = 12.7; 95% CI: 7.7-20.1) along with reports from grade 2 hospitals (aOR = 1.6; 95% CI:1.2-2.2) and those from non-HBV related departments (aOR = 5.3; 95% CI: 4.1-7.0) were independently associated with being 'misclassified' in NNDRS. Conclusions: We identified discrepancies in the accuracy of HBV case-reporting in the project hospitals. Onsite training on the use of anti-HBc IgM testing as well as on HBV case definitions and reporting procedures are needed to accurately assess program effectiveness and ensure case-patients are referred to appropriate treatment and care. Routine surveillance evaluations such as this can be useful for improving data quality and monitoring program effectiveness.

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Section: Introductionmentioning

confidence: 99%

Using a hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu provinces to improve data quality and assess program effectiveness, China, 2015

et al. 2020

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“…China has the largest burden of chronic HBV with ~86 million people infected 29 . In 1990, more than 8% of children at least 5 years of age in the WPR had chronic HBV infection 30 . In 2013, WPR countries/ areas prioritized increasing hepatitis B vaccine birth-dose and third-dose coverage in an effort to reduce this figure below 1% by 2017, a WHO target 30 .…”

Section: Where Have Been the Key Areas Of Progress Towards The 2030 Ementioning

confidence: 99%

“…In 1990, more than 8% of children at least 5 years of age in the WPR had chronic HBV infection 30 . In 2013, WPR countries/ areas prioritized increasing hepatitis B vaccine birth-dose and third-dose coverage in an effort to reduce this figure below 1% by 2017, a WHO target 30 . This same target of <1% chronically infected globally was set for 2020, but the target was achieved both in the WPR and globally in 2017 with 5-year-old children having a prevalence of 0.93% 30 .…”

Section: Where Have Been the Key Areas Of Progress Towards The 2030 Ementioning

confidence: 99%

Progress towards elimination goals for viral hepatitis

Cox

El-Sayed

Kao

et al. 2020

Nat Rev Gastroenterol Hepatol

155

159

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Is elimination of viral hepatitis by 2030 feasible? Andrea L. Cox. Hepatitis B virus (HBV) and hepatitis C virus (HCV) combined are among the top four global infectious disease killers alongside tuberculosis, malaria and HIV 1. Although the number of people in the world dying from HIV, tuberculosis and malaria have all declined since 2008, global deaths from chronic HBV and HCV infection continue to rise, with more than 1.4 million deaths each year 1. Globally, HBV-related liver disease represents the seventh highest cause of mortality worldwide 2. Given this burden, viral hepatitis elimination should be a priority. However, available evidence demonstrates that global viral hepatitis elimination by 2030 is highly unlikely. Rates of hepatitis B and C diagnosis are very low, averaging 8% and 18%, respectively, globally 1. Although some regions are approaching prophylaxis and prevalence targets for HBV infection, studies suggest that all regions must substantially scale up rates of diagnosis and access to treatment to meet the global targets 3-5. For HCV infection, 80% of high-income countries are not on track to meet HCV elimination targets by 2030, and 67% will

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“…By 2006, more than 98% of children were completing the three-dose hepatitis B vaccination series each year. However, an estimated 90 million individuals, which represents the majority of those over 30 years of age [5], are HBV surface antigen positive (HBsAg+) and at risk of developing cirrhosis and liver cancer [6,7]. Persons who are HBsAg+ may be capable of transmitting HBV to susceptible persons.…”

Section: Introductionmentioning

confidence: 99%

Using a Hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu Provinces to improve data quality and assess program effectiveness, China, 2015

Zheng

Millman²,

Rainey

et al. 2019

Preprint

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Background: Monitoring hepatitis B surveillance data is important for evaluating progress towards global hepatitis B elimination goals. Accurate classification of acute and chronic hepatitis infections is essential for assessing program effectiveness. Methods: We evaluated hepatitis B case-reporting at six hospitals in Fujian, Hainan and Gansu provinces in 2015 to assess the accuracy of case classification. We linked national notifiable disease report system (NNDRS) HBV case-reports with hospital information systems and extracted information on age, gender, admitting ward and viral hepatitis diagnosis from medical records. To assess accuracy, we compared NNDRS reported case-classifications with the national HBV case definitions. Multivariable logistic regression was used to identify factors associated with misclassification. Results: Of the 1,420 HBV cases reported to NNDRS, 23 (6.5%) of the 352 acute reports and 648 (60.7%) of the 1,068 chronic reports were correctly classified. Of the remaining, 318 (22.4%) were misclassified and 431 (30.4%) could not be classified due to the lack of supporting information. According to the multivariable analysis, HBV cases reported from Hainan (aOR=1.8; 95% CI: 1.3-2.4) and Gansu (aOR=12.7; 95% CI: 7.7-20.1) along with reports from grade 2 hospitals (aOR=1.6; 95% CI:1.2-2.2) and those from non-HBV related departments (aOR=5.3; 95% CI: 4.1-7.0) were independently associated with being ‘misclassified’ in NNDRS. Conclusions: We identified discrepancies in the accuracy of HBV case-reporting in the project hospitals. Onsite training on the use of anti-HBc IgM testing as well as on HBV case definitions and reporting procedures are needed to accurately assess program effectiveness and ensure case-patients are referred to appropriate treatment and care. Routine surveillance evaluations such as this can be useful for improving data quality and monitoring program effectiveness.

show abstract

Progress Toward Hepatitis B Control and Elimination of Mother-to-Child Transmission of Hepatitis B Virus — Western Pacific Region, 2005–2017

Cited by 50 publications

References 4 publications

Using a hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu provinces to improve data quality and assess program effectiveness, China, 2015

Using a hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu provinces to improve data quality and assess program effectiveness, China, 2015

Progress towards elimination goals for viral hepatitis

Using a Hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu Provinces to improve data quality and assess program effectiveness, China, 2015

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