Pakistan is one of the only two countries in the world where poliomyelitis virus is still not eradicated. Efforts from government such as Expanded Programme on Immunizations (EPI), which has received ample international funding, have not been successful as some sub-sections of population have a negative attitude towards vaccinations. These people generally belong to areas with a lack of education as well as strong influence of religious leaders, who are known to perpetuate misconceptions that the purpose of vaccinations is to sterilize future generations, they are not made from halal products, or are an agenda by Western intelligence agencies to gather information. Also, there are other cultural and social barriers, such as lack of female vaccinators and concerns about their handling. The stance of local people is compared with Muslim leaders and laws of other Islamic countries. Furthermore, a global vaccine confidence survey is discussed to evaluate Pakistan’s position in the broader context.