Progress toward resolving the controversy of positive Vs. negative interstitial fluid pressure.

Brace, Robert A.

doi:10.1161/01.res.49.2.281

Cited by 25 publications

(17 citation statements)

References 91 publications

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“…In this respect it appears relevant that the wick method presently used may overestimate tissue-fluid COP [11,21], However, indirect measurements also indicate that extravasular albumin, in normals about 60% of the total albumin pool [22], becomes depleted even more than the plasma albu min during chronic protein loss [23,24].…”

Section: Discussionmentioning

confidence: 99%

Lowered Tissue-Fluid Oncotic Pressure Protects the Blood Volume in the Nephrotic Syndrome

Koomans¹,

Geers²,

Mees³

et al. 1986

Nephron

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We have studied the role of adjustments of tissue-fluid colloid osmotic pressure (COP) in the maintenance of the blood volume in 10 patients with the nephrotic sydrome before and after diuretic treatment until dry weight. A mean weight reduction of 13.5 ± 6.4 kg was attended by a fall in blood volume in 3 patients and no change in 6, but the final blood volume was within the normal range: 84.3 ± 3.7 ml/kg (normal value: 87.6 ± 8.8 ml/kg). Albumin content and COP of tissue-fluid, obtained with subcutaneous wicks, were low before edema removal and rose slightly after it, parallel to changes in the plasma. Thus, the transcapillary gradient in COP did not change: 6.5 ± 1.5 mm Hg before and 6.2 ± 1.7 mm Hg after diuretic treatment. Considering the low plasma COP, 8.6 ± 1.6 mm Hg in edematous and 11.7 ± 3.7 mm Hg in dry conditions, this gradient was only slightly below the value of about 10 mm Hg normally found with this technique. We conclude that a lowered tissue-fluid COP is important for the preservation of blood volume in dry patients with the nephrotic syndrome. In addition, this adaptation can explain why the blood volume is often normal and not expanded despite the sometimes huge overhydration in these patients.

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Section: Discussionmentioning

confidence: 99%

Lowered Tissue-Fluid Oncotic Pressure Protects the Blood Volume in the Nephrotic Syndrome

Koomans¹,

Geers²,

Mees³

et al. 1986

Nephron

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“…90, 91 Except for hyaluronan, most GAGs are proteoglycans consisting of a carbohydrate GAG attached to a core protein that interacts with the collagen matrix. 92 Measured P i reflects a balance between matrix hydrostatic and osmotic pressures (Figure 4): 93, 94

{normalP}_{normali} \propto {normalP}_{collagen} - Π_{GAG}

…”

Section: Extracellular Fluid Dynamicsmentioning

confidence: 99%

Body Fluid Dynamics

Bhave

Neilson²

2011

Journal of the American Society of Nephrology

152

166

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Pioneering investigations conducted over a half century ago on tonicity, transcapillary fluid exchange, and the distribution of water and solute serve as a foundation for understanding the physiology of body fluid spaces. With passage of time, however, some of these concepts have lost their connectivity to more contemporary information. Here we examine the physical forces determining the compartmentalization of body fluid and its movement across capillary and cell membrane barriers, drawing particular attention to the interstitium operating as a dynamic interface for water and solute distribution rather than as a static reservoir. Newer work now supports an evolving model of body fluid dynamics that integrates exchangeable Na+ stores and transcapillary dynamics with advances in interstitial matrix biology.

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“…It has long been appreciated that IFP involves two components: freely mobile and relatively immobile fluid phases (Brace, 1981). The majority of interstitial fluid is immobile (historically also called gel-fluid, although not all the oncotically active molecules form a gel).…”

Section: Fourth That the Discrepancy Between Our Respective Results mentioning

confidence: 99%

“…Historical methods for measuring IFP including micropipette, needle, WN and perforated capsule can measure pressure only in the free-fluid-phase (reviewed in Brace, 1981). In contrast, the PC measures fluid pressures associated with both phases.…”

Section: Fourth That the Discrepancy Between Our Respective Results mentioning

confidence: 99%

“…Brace notes that many investigators equated the free-fluid component of interstitial pressure with IFP because that was all that was measurable with classical techniques (Figure S1H); this seemed reasonable at the time because the primary interest then was in edema (Brace, 1981). We are no longer limited to, nor solely interested in, measuring the free-fluid component of IFP.…”

Section: Fourth That the Discrepancy Between Our Respective Results mentioning

confidence: 99%

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Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning

et al. 2014

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Progress toward resolving the controversy of positive Vs. negative interstitial fluid pressure.

Cited by 25 publications

References 91 publications

Lowered Tissue-Fluid Oncotic Pressure Protects the Blood Volume in the Nephrotic Syndrome

Lowered Tissue-Fluid Oncotic Pressure Protects the Blood Volume in the Nephrotic Syndrome

Body Fluid Dynamics

Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning

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